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Serial Assessment of Myocardial Properties Using Cyclic Variation of Integrated Backscatter in an Adriamycin- Induced Cardiomyopathy Rat Model

정남식|강석민|이종두|조상호|편욱범|이주영|안미영|강웅철|하종원|전태주
연세대학교의과대학 (Yonsei University College of Medicine)|2005.02|Yonsei Medical Journal|제46권 제1호|pp. 73-77

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참고문헌

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초록

Abstract

Although adriamycin (Doxorubicin) is one of the most effective and useful antineoplastic agents for the treatment of a variety of malignancies, its repeated administration can induce irreversible myocardial damage and resultant heart failure. Currently, no marker to detect early cardiac damage is available. The purpose of this study was to investigate whether an assessment of the acoustic properties of the myocardium could enable the earlier detection of myocardial damage after adriamycin chemotherapy. Forty Wistar rats were treated with adriamycin (2mg/kg, i.v.) once a week for 2, 4, 6 or 8 weeks consecutively. Left ventricular ejection fraction (LVEF) was calculated using M-mode echocardiography data. The magnitude of cardiac cycle dependent variation of integrated backscatter (CVIB) of the myocardium was measured in the mid segment of the septum and in the posterior wall of the left ventricle, using a real time two dimensional integrated backscatter imaging system. LVEF was significantly lower in the adriamycin-treated 8-week group than in the controls (75±9 vs 57±8%, p<0.05). Myocyte damage was only seen in the 8-week adriamycin-treated group. However, no significant changes of CVIB were observed between baseline or during follow-up in the ADR or control group. In conclusion, serial assessment of the acoustic properties of the myocardium may not be an optimal tool for the early detection of myocardial damage after doxorubicin chemotherapy in a rat model.

참고문헌 (19)

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관련 논문AI추천

High-Intensity Focused Ultrasound Induced Changes in Left Ventricular Two-Dimensional Speckle-Tracking Strain in a Mouse ModelSang-Hoon Seol한국심초음파학회 · Journal of Cardiovascular Imaging2021 · 제29권 제2호15MHz 고주파탐촉자를 이용한 백서의 Adriamycin 유발 심근증 모델의 평가강진형, 김재형, 김희열, 박지원, 윤호중, 임효영, 전희경, 정성욱, 채장성, 최규보, 최주연, 홍순조한국심초음파학회 · Journal of Cardiovascular Imaging2000 · 제8권 제1호Use of Speckle Tracking Echocardiography to Detect Induced Regional Strain Changes in the Murine Myocardium by Acoustic Radiation ForceAndrew Kohut, Ankur Chaudhury, Austin Wanek, Devasena Ponnalagu, Harpreet Singh한국심초음파학회 · Journal of Cardiovascular Imaging2021 · 제29권 제2호흰쥐에서 급성 Adriamycin 유발 심근증과 세포 자멸과의 관계: 15 MHz 고주파 탐촉자를 이용한 연구강진형, 김재형, 박철수, 윤호중, 이정화, 전희경, 정해억, 조은주, 채장성, 최규보, 최윤석, 홍순조한국심초음파학회 · Journal of Cardiovascular Imaging2002 · 제10권 제2호A Case of Reversible but Highly Vulnerable Adriamycin-induced Cardiomyopathy: A Multi-modality Imaging Approach윤호중, Jung Im Jung, Kyung-Soon Hong, Mi-Hyang Jung, Sang Min Park한국심초음파학회 · Journal of Cardiovascular Imaging2019 · 제27권 제2호Pacing-Induced Alterations in Left Ventricular Mechanical Properties: Effect of Pacing Sites심지영한국심초음파학회 · Journal of Cardiovascular Imaging2011 · 제19권 제1호

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