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Estimated Prevalence and Risk Factor for Age-related Maculopathy

변석호|이성철|고형준|권오웅|김지현|노미인
연세대학교의과대학 (Yonsei University College of Medicine)|2008.12|Yonsei Medical Journal|제49권 제6호|pp. 931-941

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키워드

triglyceridehepatitis BAge-related maculopathyhigh-density lipoprotein
주제분류의학일반

초록

Purpose: To assess the estimate prevalence and risk factors for age-related maculopathy (ARM) in Seoul, Korea. Patients and Methods: We examined 9,530 subjects with, 40 years of age or older between January 2006 and December 2006 in Seoul, Korea. Subjects underwent fundus photography, clinical examinations (including blood analyses), and completed detailed questionnaires. Fundus images were graded according to definitions from the Wisconsin Age-Related Maculopathy Grading System. Results: ARM was present in 235 subjects, corresponding to an estimate prevalence of 2.46%. Hepatitis B infection (positive status for HBsAg and HBcAb), serum triglyceride levels and high density lipoprotein levels remained as significant risk factors after age-adjustment. Multivariate analyses showed that the prevalence of ARM was significantly higher in older subjects [odds ratio (OR) 1.134; 95% CI 1.114-1.154] and those who were seropositive for hepatitis B surface antigen (OR 2.566; 95% CI 1.519-4.335). Conclusion: The estimated prevalence of ARM was 2.46%. Age and hepatitis B infection may increase the risk of ARM.

Abstract

Purpose: To assess the estimate prevalence and risk factors for age-related maculopathy (ARM) in Seoul, Korea. Patients and Methods: We examined 9,530 subjects with, 40 years of age or older between January 2006 and December 2006 in Seoul, Korea. Subjects underwent fundus photography, clinical examinations (including blood analyses), and completed detailed questionnaires. Fundus images were graded according to definitions from the Wisconsin Age-Related Maculopathy Grading System. Results: ARM was present in 235 subjects, corresponding to an estimate prevalence of 2.46%. Hepatitis B infection (positive status for HBsAg and HBcAb), serum triglyceride levels and high density lipoprotein levels remained as significant risk factors after age-adjustment. Multivariate analyses showed that the prevalence of ARM was significantly higher in older subjects [odds ratio (OR) 1.134; 95% CI 1.114-1.154] and those who were seropositive for hepatitis B surface antigen (OR 2.566; 95% CI 1.519-4.335). Conclusion: The estimated prevalence of ARM was 2.46%. Age and hepatitis B infection may increase the risk of ARM.

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