A Case of Suspected Isotretinoin-Induced Malformation in a Baby of a Mother Who Became Pregnant One Month after Discontinuation of the Drug
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotreinoin are needed.
Abstract
Isotretinoin is a known human teratogen that can cause multiple malformations. At present, women who conceive one cycle after discontinuing isotretinoin are told that their teratogenic risk is not higher than baseline. We present a case of both ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotreinoin are needed.
참고문헌 (10)
- "Accutane-exposed pregnancies--California", MMWR Morb Mortal Wkly Rep, 49, pp.28~31 (1999)
- Brinker A, "Trends in adherence to a revised risk management program designed to decrease or eliminate isotretinoin-exposed pregnancies: evaluation of the accutane SMART program", Arch Dermatol, 141, pp.563~569 (2005)
- Mitchell AA, "A pregnancy-prevention program in women of childbearing age receiving isotretinoin", N Engl J Med, 333, pp.101~106 (1995)
- Mirjana Vucinovic, "Maternal and Neonatal Effects of Substance Abuse during Pregnancy: Our Ten-year Experience", Yonsei Medical Journal, 49(5), pp.705~713 (2008), 연세대학교의과대학
- Honein MA, "Can we ensure the safe use of known human teratogens?: the iPLEDGE test case", Drug Saf, 30, pp.5~15 (2007)
- Webster WS, "Isotretinoin embryopathy and the cranial neural crest: an in vivo and in vitro study", J Craniofac Genet Dev Biol, 6, pp.211~222 (1986)
- Suutarla S, "Microtia in Finland: comparison of characteristics in different populations", Int J Pediatr Otorhinolaryngol, 71, pp.1211~1217 (2007)
- Hersh JH, "Retinoic acid embryopathy: timing of exposure and effects on fetal development", JAMA, 254, pp.909~910 (1985)
- Dai WS, "Safety of pregnancy after discontinuation of isotretinoin", Arch Dermatol, 125, pp.362~365 (1989)
- Nulman I, "Steady-state pharmacokinetics of isotretinoin and its 4-oxo metabolite: implications for fetal safety", J Clin Pharmacol, 38, pp.926~930 (1998)