당뇨병 산모에서 출생한 다발성 기형 신생아 1례
Multiple Congenital Anomalies in a Neonate of a Diabetic Mother
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Maternal diabetes is known to have teratogenic effects which increase the risk for congenital anomalies, such as caudal dysplasia, cardiac defects, hydronephrosis, and small left colon syndrome. Infants of diabetic mothers have a 10-fold higher frequency of anomalies in the central nervous system and a 5-fold higher frequency of congenital heart defects. However, jejunal atresia combined with multiple anomalies of the face, ears, and hands has rarely been reported. Herein we report a neonate born to a diabetic mother, who had hemifacial microsomia, displacement of the lacrimal ducts, polydactyly of the right hand, microtia of the right ear and proximal jejunal atresia presenting as bile regurgitation on the 1st day of life.
Abstract
Maternal diabetes is known to have teratogenic effects which increase the risk for congenital anomalies, such as caudal dysplasia, cardiac defects, hydronephrosis, and small left colon syndrome. Infants of diabetic mothers have a 10-fold higher frequency of anomalies in the central nervous system and a 5-fold higher frequency of congenital heart defects. However, jejunal atresia combined with multiple anomalies of the face, ears, and hands has rarely been reported. Herein we report a neonate born to a diabetic mother, who had hemifacial microsomia, displacement of the lacrimal ducts, polydactyly of the right hand, microtia of the right ear and proximal jejunal atresia presenting as bile regurgitation on the 1st day of life.
참고문헌 (18)
- Casson IF, "Outcomes of pregnancy in insulin dependent diabetic women:results of a five year population cohort study", BMJ, 315, pp.275~278 (1997)
- Aberg A, "Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes", Early Hum Dev, 61, pp.85~95 (2001)
- Neiger R, "Fetal macrosomia in the diabetic patient", Clin Obstet Gynecol, 35, pp.138~150 (1992)
- Sann L, "Neonatal hypoglycemia", Biol Neonate, 58(1), pp.16~21 (1990)
- Jährig D, "Neonatal jaundice in infants of diabetic mothers", Acta Paediatr Scand, 360, pp.101~107 (1989)
- Mimouni F, "Early neonatal predictors of neonatal hypocalcemia in infants of diabetic mothers: an epidemiologic study", Am J Perinatol, 7, pp.203~206 (1990)
- Kjos SL, "Prevalence and etiology of respiratory distress in infants of diabetic mothers: predictive value of fetal lung maturation tests", Am J Obstet Gynecol, 163, pp.898~903 (1990)
- Gregory R, "Diabetic pregnancy 1977-1990: have we reached a plateau?", J R Coll Physicians Lond, 26, pp.162~166 (1992)
- Becerra JE, "Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case- control study", Pediatrics, 85, pp.1~9 (1990)
- Lindsay CA, "Pregnancy complicated by diabetes mellitus. in: Neonatal-perinatal medicine. 8th ed", pp.326~328 (2006), Mosby
- Unger E, "Regionally disturbed production of cartilage proteoglycans in malformed fetuses from diabetic rats", Diabetologia, 35, pp.517~521 (1992)
- Fine EL, "Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy", Diabetes, 48, pp.2454~2462 (1999)
- Ober C, "Diabetes mellitus; preventing anomalies through maternal metabolic intervention", Clin Obstet Gynecol, 29, pp.558~568 (1986)
- Ramos-Arroyo MA, "Maternal diabetes: the risk for specific birth defects", Eur J Epidemiol, 8, pp.503~508 (1992)
- Ewart-Toland A, "Oculoauriculovertebral abnormalities in children of diabetic mothers", Am J Med Genet, 90, pp.303~309 (2000)
- 손경란, "당뇨병 산모아에서 출생 체증군에 따른 합병증 및 주산기 인자", Korean Journal of Pediatrics, 46(5), pp.447~453 (2003), 대한소아과학회
- David A, "Hypoglossia-hypodactylia syndrome with jejunal atresia in an infant of a diabetic mother", Am J Med Genet, 43, pp.882~884 (1992)
- Tasse C, "Oculo-auriculo-vertebral spectrum(OAVS): clinical evaluation and severity scoring of 53 patients and proposal for a new classification", Eur J Med Genet, 48, pp.397~411 (2005)