Recent Changes in the Clinicopathologic Features of Korean Men with Prostate Cancer: A Comparison with Western Populations
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Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively;p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.
Abstract
Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations. Materials and Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months. Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively;p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series. Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.
참고문헌 (26)
- Giovannucci E, "Epidemiology of prostate cancer, In Comprehensive Textbook of Genitourinary Oncology. 3rd ed", pp.9~22 (2006), Lippincott Williams & Wilkins
- Jemal A, "Cancer statistics, 2010", CA Cancer J Clin, 60, pp.277~300 (2010)
- "Korea Statistical Information Service"[URL]
- 장혁재, "Current status and characteristics of hypertension control in community resident elderly Korean people: Data from a Korean longitudinal study on health and aging (KLoSHa study)", Hypertension Research, 31(1), pp.97~105
- Parkin DM, "Global cancer statistics, 2002", CA Cancer J Clin, 55, pp.74~108 (2005)
- Seo HK, "Korean Urological Oncologic Society Prostate Cancer Study Group. Detection rate of prostate cancer according to prostate-specific antigen and digital rectal examination in Korean men: a nationwide multicenter study", Urology, 70, pp.1109~1112 (2007)
- Song C, "Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy", UROLOGY, 68(4), pp.820~824
- Epstein JI, "ISUP Grading Committee. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma", Am J Surg Pathol, 29, pp.1228~1242 (2005)
- Freedland SJ, "Defining the ideal cutpoint for determining PSA recurrence after radical prostatectomy. Prostate-specific antigen", Urology, 6, pp.365~369 (2003)
- Grossfeld GD, "Is ethnicity an independent predictor of prostate cancer recurrence after radical prostatectomy?", J Urol, 168, pp.2510~2515 (2002)
- Freedland SJ, "Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database", Urology, 60, pp.670~674 (2002)
- Hernandez DJ, "Contemporary evaluation of the D’amico risk classification of prostate cancer", Urology, 70, pp.931~935 (2007)
- Godley PA, "Racial differences in mortality among Medicare recipients after treatment for localized prostate cancer", J Natl Cancer Inst, 95, pp.1702~1710 (2003)
- Haenszel W, "Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States", J Natl Cancer Inst, 40, pp.43~68 (1968)
- Yu H, "Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States", Int J Epidemiol, 20, pp.76~81 (1991)
- The Korean Urological Association, "Data on statistics of management in resident training hospital in the Korean Urological Association in the year 2007", Korean J Urol, 49, pp.1171~1172 (2008)
- Song C, "Mass screening for prostate cancer in Korea: a population based study", J Urol, 180, pp.1949~1952 (2008)
- Cohen JH, "Racial differences in clinical progression among Medicare recipients after treatment for localized prostate cancer (United States)", Cancer Causes Control, 17, pp.803~811 (2006)
- van Houten ME, "Differences in reproductive endocrinology between Asian men and Caucasian men--a literature review", Asian J Androl, 2, pp.13~20 (2000)
- Wu AH, "Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men", Cancer Epidemiol Biomarkers Prev, 10, pp.533~538 (2001)
- Hoffman MA, "Is low serum free testosterone a marker for high grade prostate cancer?", J Urol, 163, pp.824~827 (2000)
- Hsing AW, "Androgen and prostate cancer: is the hypothesis dead?", Cancer Epidemiol Biomarkers Prev, 17, pp.2525~2530 (2008)
- Roehl KA, "Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results", J Urol, 172, pp.910~914 (2004)
- Schroeck FR, "Do nomograms predict aggressive recurrence after radical prostatectomy more accurately than biochemical recurrence alone?", BJU Int, 103, pp.603~608 (2009)
- Capitanio U, "The probability of Gleason score upgrading between biopsy and radical prostatectomy can be accurately predicted", Int J Urol, 16, pp.526~529 (2009)