Risk Factors of Permanent Stomas in Patients with Rectal Cancer after Low Anterior Resection with Temporary Stomas
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Purpose: The aim of this study was to identify risk factors influencing permanent stomas after low anterior resection with temporary stomas for rectal cancer. Materialsand Methods: A total of 2528 consecutive rectal cancer patients who had undergonelow anterior resection were retrospectively reviewed. Risk factors for permanentstomas were evaluated among these patients. Results: Among 2528 cases of rectal cancer, a total of 231 patients had a temporary diverting stoma. Among these cases, 217 (93.9%) received a stoma reversal. The median period between primary surgery and stoma reversal was 7.5 months. The temporary and permanentstoma groups consisted of 203 and 28 patients, respectively. Multivariate analysis showed that independent risk factors for permanent stomas were anastomotic-related complications (p=0.001) and local recurrence (p=0.001). The 5-year overall survival for the temporary and permanent stoma groups were 87.0% and 70.5%, respectively (p<0.001). Conclusion: Rectal cancer patients who have temporarystomas after low anterior resection with local recurrence and anastomotic-related complications may be at increased risk for permanent stoma.
Abstract
Purpose: The aim of this study was to identify risk factors influencing permanent stomas after low anterior resection with temporary stomas for rectal cancer. Materialsand Methods: A total of 2528 consecutive rectal cancer patients who had undergonelow anterior resection were retrospectively reviewed. Risk factors for permanentstomas were evaluated among these patients. Results: Among 2528 cases of rectal cancer, a total of 231 patients had a temporary diverting stoma. Among these cases, 217 (93.9%) received a stoma reversal. The median period between primary surgery and stoma reversal was 7.5 months. The temporary and permanentstoma groups consisted of 203 and 28 patients, respectively. Multivariate analysis showed that independent risk factors for permanent stomas were anastomotic-related complications (p=0.001) and local recurrence (p=0.001). The 5-year overall survival for the temporary and permanent stoma groups were 87.0% and 70.5%, respectively (p<0.001). Conclusion: Rectal cancer patients who have temporarystomas after low anterior resection with local recurrence and anastomotic-related complications may be at increased risk for permanent stoma.
참고문헌 (21)
- Knight CD, "improved technique for low anterior resection of the rectum using the EEA stapler", Surgery, 88, pp.710~714 (1980)
- Heald RJ, "The low stapled anastomosis", Br J Surg, 68, pp.333~337 (1981)
- Heald RJ, "Recurrence and survival after total mesorectal excision for rectal cancer", Lancet, 1, pp.1479~1482 (1986)
- Sauer R, "Preoperative versus postoperative chemoradiotherapy for rectal cancer", N Engl J Med, 351, pp.1731~1740 (2004)
- Matthiessen P, "Population-based study of risk factors for postoperative death after anterior resection of the rectum", Br J Surg, 93, pp.498~503 (2006)
- Bokey EL, "Morbidity, mortality and survival following resection for carcinoma of the rectum at Concord Hospital", Aust N Z J Surg, 60, pp.253~259 (1990)
- Tan WS, "Meta-analysis of defunctioning stomas in low anterior resection for rectal cancer", Br J Surg, 96, pp.462~472 (2009)
- Pakkastie TE, "A randomised study of colostomies in low colorectal anastomoses", Eur J Surg, 163, pp.929~933 (1997)
- Matthiessen P, "Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial", Ann Surg, 246, pp.207~214 (2007)
- Lindgren R, "What is the risk for a permanent stoma after low anterior resection of the rectum for cancer? A six-year follow-up of a multicenter trial", Dis Colon Rectum, 54, pp.41~47 (2011)
- Nelson RS, "Permanent diversion rates after neoadjuvant therapy and coloanal anastomosis for rectal cancer", Am J Surg, 198, pp.765~770 (2009)
- Hassan I, "Impact of pelvic radiotherapy on morbidity and durability of sphincter preservation after coloanal anastomosis for rectal cancers", Dis Colon Rectum, 51, pp.32~37 (2008)
- Maggiori L, "Conservative management is associated with a decreased risk of definitive stoma after anastomotic leakage complicating sphincter-saving resection for rectal cancer", Colorectal Dis, 13, pp.632~637 (2011)
- Mala T, "Morbidity related to the use of a protective stoma in anterior resection for rectal cancer", Colorectal Dis, 10, pp.785~788 (2008)
- den Dulk M, "A multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study", Lancet Oncol, 8, pp.297~303 (2007)
- Junginger T, "Permanent stoma after low anterior resection for rectal cancer", Dis Colon Rectum, 53, pp.1632~1639 (2010)
- David GG, "Loop ileostomy following anterior resection: is it really temporary?", Colorectal Dis, 12, pp.428~432 (2010)
- Chun LJ, "Defunctioning loop ileostomy for pelvic anastomoses: predictors of morbidity and nonclosure", Dis Colon Rectum, 55, pp.167~174 (2012)
- Seo SI, "Characteristics and risk factors associated with permanent stomas after sphincter-saving resection for rectal cancer", World J Surg, 37, pp.2490~2496 (2013)
- Lim SW, "Risk factors for permanent stoma after low anterior resection for rectal cancer", Langenbecks Arch Surg, 398, pp.259~264 (2013)
- Kairaluoma M, "Outcome of temporary stomas. A prospective study of temporary intestinal stomas constructed between 1989 and 1996", Dig Surg, 19, pp.45~51 (2002)
