In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
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Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibilityof tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10-3 μg/mL in doxycycline-treated group. Whereas in 0.71×10-3 μg/mL tigecycline-treated group. These findings indicate that tigecyclinemay be a therapeutic option for the treatment of scrub typhus.
Abstract
Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibilityof tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10-3 μg/mL in doxycycline-treated group. Whereas in 0.71×10-3 μg/mL tigecycline-treated group. These findings indicate that tigecyclinemay be a therapeutic option for the treatment of scrub typhus.
참고문헌 (23)
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