Bone Marrow Suppression and Hemophagocytic Histiocytes Are Common Findings in Korean Severe Fever with Thrombocytopenia Syndrome Patients
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초록
The causes of cytopenia in patients with severe fever with thrombocytopenia syndrome (SFTS) are not fully understood until now. We reviewed the bone marrow (BM) findings of patients with SFTS to unravel the cause of the cytopenia. Three Korean SFTS were enrolled in this study. Thrombocytopenia, neutropenia, and anemia were detected in all three patients. Severe hypocellular marrow(overall cellularity <5%) and a decreased number of megakaryocytes were noted in one patient, and hypo-/normocellular marrow and an increased number of hemophagocytic histiocytes were observed in two patients. Megakaryocytes were relatively preserved in two patients. Although a limited number of cases are available, our observations suggest that both BM suppression and peripheral destruction or sequestration are causes of cytopenia of patients with SFTS. To the best of our knowledge, this is the first well documented pathologic evaluation of Korean SFTS.
Abstract
The causes of cytopenia in patients with severe fever with thrombocytopenia syndrome (SFTS) are not fully understood until now. We reviewed the bone marrow (BM) findings of patients with SFTS to unravel the cause of the cytopenia. Three Korean SFTS were enrolled in this study. Thrombocytopenia, neutropenia, and anemia were detected in all three patients. Severe hypocellular marrow(overall cellularity <5%) and a decreased number of megakaryocytes were noted in one patient, and hypo-/normocellular marrow and an increased number of hemophagocytic histiocytes were observed in two patients. Megakaryocytes were relatively preserved in two patients. Although a limited number of cases are available, our observations suggest that both BM suppression and peripheral destruction or sequestration are causes of cytopenia of patients with SFTS. To the best of our knowledge, this is the first well documented pathologic evaluation of Korean SFTS.
참고문헌 (12)
- Yu XJ, "Fever with thrombocytopenia associated with a novel bunyavirus in China", N Engl J Med, 364, pp.1523~1532 (2011)
- QuanTai X, "A study of cytological changes in the bone marrow of patients with severe fever with thrombocytopenia syndrome", PLoS One, 8, pp.e83020~ (2013)
- Takahashi T, "The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan", J Infect Dis, 209, pp.816~827 (2014)
- Jin C, "Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57", BL6 mouse model, 2012, pp.109, 10053~10058
- Kim WY, "Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea", Clin Infect Dis, 60, pp.1681~1683 (2015)
- Ding S, "Age is a critical risk factor for severe fever with thrombocytopenia syndrome", PLoS One, 9, pp.e111736~ (2014)
- Gai ZT, "Clinical progress and risk factors for death in severe fever with thrombocytopenia syndrome patients", J Infect Dis, 206, pp.1095~1102 (2012)
- Deng B, "Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China", PLoS One, 8, pp.e80802~ (2013)
- Jordan MB, "Hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis: a journey of a thousand miles begins with a single (big) step", Bone Marrow Transplant, 42, pp.433~437 (2008)
- Sun Y, "Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome", J Infect Dis, 206, pp.1085~1094 (2012)
- Usmani GN, "Advances in understanding the pathogenesis of HLH", Br J Haematol, 161, pp.609~622 (2013)
- Oh WS, "Plasma exchange and ribavirin for rapidly progressive severe fever with thrombocytopenia syndrome", Int J Infect Dis, 18, pp.84~86 (2014)