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Severe Fever with Thrombocytopenia Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

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초록

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the newly discovered SFTS Bunyavirus, and there have been no case reports of SFTS patients presenting with hemophagocytic lymphohistiocytosis (HLH) in the English literature. We report a case of SFTS presenting with HLH in a 73-year-old immunocompetent male farmer. Although the patient had poor prognostic factors for SFTS, such as old age and central nervous system symptoms, he recovered fully with supportive care.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the newly discovered SFTS Bunyavirus, and there have been no case reports of SFTS patients presenting with hemophagocytic lymphohistiocytosis (HLH) in the English literature. We report a case of SFTS presenting with HLH in a 73-year-old immunocompetent male farmer. Although the patient had poor prognostic factors for SFTS, such as old age and central nervous system symptoms, he recovered fully with supportive care.

참고문헌 (9)

  1. Xue-Jie Yu, "Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China", New England Journal of Medicine, 364(16), pp.1523~1532 (2011), New England Journal of Medicine (NEJM[DOI]
  2. Takahashi T, "The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan", J Infect Dis, 209, pp.816~827 (2014)[DOI]
  3. Kim KH, "Severe fever with thrombocytopenia syndrome, South Korea, 2012", Emerg Infect Dis, 19, pp.1892~1894 (2013)
  4. Ding F, "Epidemiologic features of severe fever with thrombocytopenia syndrome in China, 2011-2012", Clin Infect Dis, 56, pp.1682~1683 (2013)
  5. Epidemiologic and clinical characteristics of severe fever with thrombocytopenia syndrome in the Republic of Korea, "Shin JS", Public Health Weekly, 493~498, pp.Public Health Weekly Report 7 (2014)
  6. Jordan MB, "How I treat hemophagocytic lymphohistiocytosis", Blood, 118, pp.4041~4052 (2011)
  7. QuanTai X, "A study of cytological changes in the bone marrow of patients with severe fever with thrombocytopenia syndrome", PLoS One, 8, pp.e83020~ (2013)
  8. Weng Y, "Clinical and laboratory characteristics of severe fever with thrombocytopenia syndrome in Chinese patients", Braz J Infect Dis, 18, pp.88~91 (2014)
  9. Trottestam H, "Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94treatment protocol", Blood, 118, pp.4577~4584 (2011)

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