An Emerging Role for Circular RNAs in Osteoarthritis
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초록
Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form acovalently closed continuous loop without 5’ or 3’ polarities. With the development of high throughput sequencing technology, alarge number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs areabundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAscan serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription, as well as proteintranslation. Osteoarthritis (OA) is the most common chronic degenerative joint disease. CircRNAs are differentially expressed inOA cartilage. Moreover, some circRNAs are involved in multiple pathological processes during OA, mainly extracellular matrixdegradation, inflammation, and apoptosis. In this review, we briefly delineate the biogenesis, characteristics, and biofunctions ofcircRNAs, and then, focus on the role of circRNAs in the occurrence and progression OA.
Abstract
Circular RNAs (circRNAs) are currently classed as non-coding RNAs that, unlike the better known canonical linear RNAs, form acovalently closed continuous loop without 5’ or 3’ polarities. With the development of high throughput sequencing technology, alarge number of circRNAs have been discovered in many species. More importantly, growing evidence suggests that circRNAs areabundant, evolutionally conserved, and relatively stable in cells and tissues. Strikingly, recent studies have discovered that circRNAscan serve as microRNA sponges, interact with RNA-binding protein, and regulate gene transcription, as well as proteintranslation. Osteoarthritis (OA) is the most common chronic degenerative joint disease. CircRNAs are differentially expressed inOA cartilage. Moreover, some circRNAs are involved in multiple pathological processes during OA, mainly extracellular matrixdegradation, inflammation, and apoptosis. In this review, we briefly delineate the biogenesis, characteristics, and biofunctions ofcircRNAs, and then, focus on the role of circRNAs in the occurrence and progression OA.
참고문헌 (64)
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