Ataxia-Telangiectasia-Mutated Protein Expression as a Prognostic Marker in Adenoid Cystic Carcinoma of the Salivary Glands
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Purpose: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiplerecurrences and late distant metastasis. Biological markers for assessing the prognosis of ACC have remained elusive. Thepurpose of this study was to investigate whether the protein expressions of ataxia telangiectasia mutated (ATM), p53, and ATMmediatedphosphorylated p53 are related to patient survival in ACC. Materials and Methods: In this study, 48 surgical samples were used to assess the expressions of ATM and its downstream targetp53. Fisher’s exact test and Kaplan-Meier analysis were conducted to evaluate the role of ATM, p53, and phospho-p53 (S15) proteinexpressions in predicting patient survival and distant metastasis. Results: Myb expression was positive in 85.4% of ACCs, but did not reflect patient survival rate. In contrast, low expression of ATMin cancer cells was significantly correlated with poor survival rate (p=0.037). Moreover, under positive p53 expression, low expressionof ATM was highly predictive of poor survival in ACC (p=0.017). Conclusion: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic markerfor assessing survival rate in patients with ACC of the salivary glands.
Abstract
Purpose: Adenoid cystic carcinoma (ACC) is a high-grade malignant tumor of the salivary glands, clinically characterized by multiplerecurrences and late distant metastasis. Biological markers for assessing the prognosis of ACC have remained elusive. Thepurpose of this study was to investigate whether the protein expressions of ataxia telangiectasia mutated (ATM), p53, and ATMmediatedphosphorylated p53 are related to patient survival in ACC. Materials and Methods: In this study, 48 surgical samples were used to assess the expressions of ATM and its downstream targetp53. Fisher’s exact test and Kaplan-Meier analysis were conducted to evaluate the role of ATM, p53, and phospho-p53 (S15) proteinexpressions in predicting patient survival and distant metastasis. Results: Myb expression was positive in 85.4% of ACCs, but did not reflect patient survival rate. In contrast, low expression of ATMin cancer cells was significantly correlated with poor survival rate (p=0.037). Moreover, under positive p53 expression, low expressionof ATM was highly predictive of poor survival in ACC (p=0.017). Conclusion: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic markerfor assessing survival rate in patients with ACC of the salivary glands.
참고문헌 (30)
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