Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning
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Purpose: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the presentstudy, we investigated the relative risk and clinical severity, including laboratory results, of non-oral route poisoning (NORP)patients, compared to oral route poisoning (ORP) patients. Materials and Methods: A single institutional toxicology database registry was utilized to gain information on clinical laboratoryresults on organophosphate poisoning patients who visited the emergency department (ED) between January 2000 and October2016. Clinical outcomes, such as mortality and complication rates, were compared using 1:2 propensity score matching in the totalcohort. Results: Among a total of 273 patients in our study, 34 experienced NORP. After 1:2 propensity score matching, rates of respiratorycomplications and mortality were higher in the ORP group than in the NORP group. However, there was no difference in hospitalizationtime and time spent in the intensive care unit between the two groups. Compared with ORP patients after matching, therelative risk of mortality in NORP patients was 0.34, and the risk of respiratory distress was 0.47. The mean level of pseudocholinesterasewas significantly higher in the NORP group than in the ORP group, while recovery rates were similar between the twogroups. Conclusion: Although the majority of NORP patients were admitted to the ED with unintentional poisoning and the relative riskof NORP was lower than that for ORP, we concluded that NORP is as critical as ORP. Considerable medical observation and intensivetherapeutic approaches are also needed for NORP patients.
Abstract
Purpose: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the presentstudy, we investigated the relative risk and clinical severity, including laboratory results, of non-oral route poisoning (NORP)patients, compared to oral route poisoning (ORP) patients. Materials and Methods: A single institutional toxicology database registry was utilized to gain information on clinical laboratoryresults on organophosphate poisoning patients who visited the emergency department (ED) between January 2000 and October2016. Clinical outcomes, such as mortality and complication rates, were compared using 1:2 propensity score matching in the totalcohort. Results: Among a total of 273 patients in our study, 34 experienced NORP. After 1:2 propensity score matching, rates of respiratorycomplications and mortality were higher in the ORP group than in the NORP group. However, there was no difference in hospitalizationtime and time spent in the intensive care unit between the two groups. Compared with ORP patients after matching, therelative risk of mortality in NORP patients was 0.34, and the risk of respiratory distress was 0.47. The mean level of pseudocholinesterasewas significantly higher in the NORP group than in the ORP group, while recovery rates were similar between the twogroups. Conclusion: Although the majority of NORP patients were admitted to the ED with unintentional poisoning and the relative riskof NORP was lower than that for ORP, we concluded that NORP is as critical as ORP. Considerable medical observation and intensivetherapeutic approaches are also needed for NORP patients.
참고문헌 (17)
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