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GC/MS를 이용한 소변 중 Pseudoephedrine과 Dextromethorphan 및 대사체의 동시분석

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주제분류화학

초록

Abstract

24 hr after oral administration of a complex (pseudoephedrine and dextromethorphan). To detect the traceamounts of parent drugs and their metabolites, acid-hydrolyzed urine was extracted and derivatized with MSTFAand MBTFA followed by gas chromatography/mass spectrometric analysis. Two parent drugs and theirmetabolites were tentatively identified as their derivatives based on the mass spectral interpretation and comparedwith previous reports. In addition, the time profile of urinary excretion rate for parent drugs and metabolitesare suggested.

참고문헌 (4)

  1. Keith Parker, "Goodman & Gilman's The Pharmacological Basis ofTherapeutics" (1997), McGraw-Hill
  2. Grattan, "Br. J. Clin. Pharmacol", pp.261~263 (1995)
  3. Chai, "J. Pharm. Biomed. Anal", pp.919~925 (1995)
  4. T. H. Eichcold, "Pharm. Biomed. Anal" (2007)

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