Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
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To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, weperformed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantationdue to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remainedhigh for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells intomediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
Abstract
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, weperformed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantationdue to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remainedhigh for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells intomediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
참고문헌 (11)
- Yoon EL, "Current status and strategies for the control of viral hepatitis A in Korea", Clin Mol Hepatol, 23, pp.196~204 (2017)
- Koff RS, "Hepatitis A", Lancet, 351, pp.1643~1649 (1998)
- Shin EC, "Natural history, clinical manifestations, and pathogenesis of hepatitis A", Cold Spring Harb Perspect Med, 8, pp.031708~ (2018)
- Vento S, "Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals", Lancet, 337, pp.1183~1187 (1991)
- Huppertz HI, "Autoimmune hepatitis following hepatitis A virus infection", J Hepatol, 23, pp.204~208 (1995)
- Vento S, "Is there a role for viruses in triggering autoimmune hepatitis", Autoimmun Rev, 3, pp.61~69 (2004)
- Mikata R, "Prolonged acute hepatitis A mimicking autoimmune hepatitis", World J Gastroenterol, 11, pp.3791~3793 (2005)
- Tabak F, "Autoimmune hepatitis induced by the prolonged hepatitis A virus infection", Ann Hepatol, 7, pp.177~179 (2008)
- Choi YS, "Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis", Gut, 64, pp.1303~1313 (2015)
- Choi YS, "Tumor necrosis factor-producing T-regulatory cells are associated with severe liver injury in patients with acute hepatitis A", Gastroenterology, 154, pp.1047~1060 (2018)
- 정민경, "Tumor Necrosis Factor and Regulatory T Cells", Yonsei Medical Journal, 60(2), pp.126~131 (2019), 연세대학교의과대학[DOI]