Update on the Management of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity
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초록
The clinical phenotypes of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity are heterogeneous with various presentationsincluding time of symptom onset, organ involvements, and underlying pathophysiology. Having a correct diagnosiscan be challenging. Understanding their respective mechanisms as well as developing a comprehensive classification and diagnosticalgorithm are pivotal for appropriate management strategy. Treatment modalities are based on the subtypes and severityof hypersensitivity reactions. Insights into the phenotypes and endotypes of hypersensitivity reactions enable personalized managementin patients with suboptimal control of disease. This review updated the recent evidence of pathophysiology, classification,diagnostic algorithm, and management of NSAID hypersensitivity reactions.
Abstract
The clinical phenotypes of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity are heterogeneous with various presentationsincluding time of symptom onset, organ involvements, and underlying pathophysiology. Having a correct diagnosiscan be challenging. Understanding their respective mechanisms as well as developing a comprehensive classification and diagnosticalgorithm are pivotal for appropriate management strategy. Treatment modalities are based on the subtypes and severityof hypersensitivity reactions. Insights into the phenotypes and endotypes of hypersensitivity reactions enable personalized managementin patients with suboptimal control of disease. This review updated the recent evidence of pathophysiology, classification,diagnostic algorithm, and management of NSAID hypersensitivity reactions.
참고문헌 (100)
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