Association between Albumin, Total Bilirubin, and Uric Acid Serum Levels and the Risk of Cancer: A Prospective Study in a Korean Population
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: In this prospective study, we evaluated the association between the serum levels of antioxidants uric acid (UA), albumin,and total bilirubin and the risk of cancer in a Korean population. Materials and Methods: A total of 15882 subjects were followed up for cancer development and cancer-related death. During thefollow-up period, 1619 cancer diagnoses and 617 cancer-related deaths were recorded. Cox proportional regression was performedto calculate the hazard ratio (HR) per standard deviation (SD) increment and 95% confidence interval (CI). The model was adjustedfor covariates such as the age, sex, smoking, alcohol consumption, physical activity, education level, body mass index, andfamily history. Sensitivity analyses using the study subjects with physiological serum levels of each indicator were also performed. Results: UA levels were positively correlated with cancer risk (HR per SD increment 1.04; 95% CI, 1.01–1.09), and albumin levelswere inversely associated with the overall cancer risk (HR, 0.92; 95% CI, 0.88–0.96) and cancer-related death (HR, 0.86; 95% CI,0.80–0.93). Total bilirubin levels were negatively correlated with the risk of cancer-related death (HR, 0.91; 95% CI, 0.83–0.99). Bycancer type, UA was positively associated with prostate cancer, total bilirubin was positively associated with liver cancer, and albuminwas inversely associated with lung cancer. Conclusion: The findings of this study support the role of antioxidants in carcinogenesis. Future large-cohort studies are needed toconfirm the predictive value of albumin, UA, and total bilirubin levels in each type of cancer.
Abstract
Purpose: In this prospective study, we evaluated the association between the serum levels of antioxidants uric acid (UA), albumin,and total bilirubin and the risk of cancer in a Korean population. Materials and Methods: A total of 15882 subjects were followed up for cancer development and cancer-related death. During thefollow-up period, 1619 cancer diagnoses and 617 cancer-related deaths were recorded. Cox proportional regression was performedto calculate the hazard ratio (HR) per standard deviation (SD) increment and 95% confidence interval (CI). The model was adjustedfor covariates such as the age, sex, smoking, alcohol consumption, physical activity, education level, body mass index, andfamily history. Sensitivity analyses using the study subjects with physiological serum levels of each indicator were also performed. Results: UA levels were positively correlated with cancer risk (HR per SD increment 1.04; 95% CI, 1.01–1.09), and albumin levelswere inversely associated with the overall cancer risk (HR, 0.92; 95% CI, 0.88–0.96) and cancer-related death (HR, 0.86; 95% CI,0.80–0.93). Total bilirubin levels were negatively correlated with the risk of cancer-related death (HR, 0.91; 95% CI, 0.83–0.99). Bycancer type, UA was positively associated with prostate cancer, total bilirubin was positively associated with liver cancer, and albuminwas inversely associated with lung cancer. Conclusion: The findings of this study support the role of antioxidants in carcinogenesis. Future large-cohort studies are needed toconfirm the predictive value of albumin, UA, and total bilirubin levels in each type of cancer.
참고문헌 (23)
- Harris IS, "The complex interplay between antioxidants and ROS in cancer", Trends Cell Biol, 30, pp.440~451 (2020)
- Waris G, "Reactive oxygen species : role in the development of cancer and various chronic conditions", J Carcinog, 5, pp.14~ (2006)
- Yiu A, "Circulating uric acid levels and subsequent development of cancer in 493281 individuals : findings from the AMORIS study", Oncotarget, 8, pp.42332~42342 (2017)
- Yan S, "Serum uric acid increases risk of cancer incidence and mortality : a systematic review and meta-analysis", Mediators Inflamm, 2015, pp.764250~ (2015)
- Kühn T, "Albumin, bilirubin, uric acid and cancer risk : results from a prospective population-based study", Br J Cancer, 117, pp.1572~1579 (2017)
- Merriel SW, "Association between unexplained hypoalbuminaemia and new cancer diagnoses in UK primary care patients", Fam Pract, 33, pp.449~452 (2016)
- Ghuman S, "Serum inflammatory markers and colorectal cancer risk and survival", Br J Cancer, 116, pp.1358~1365 (2017)
- Wagner KH, "Looking to the horizon : the role of bilirubin in the development and prevention of age-related chronic diseases", Clin Sci (Lond), 129, pp.1~25 (2015)
- Bajro MH, "Promoter length polymorphism in UGT1A1 and the risk of sporadic colorectal cancer", Cancer Genet, 205, pp.163~167 (2012)
- Kweon SS, "Cohort profile : the Namwon Study and the Dong-gu Study", Int J Epidemiol, 43, pp.558~567 (2014)
- Kolonel LN, "Relationship of serum uric acid to cancer occurrence in a prospective male cohort", Cancer Epidemiol Biomarkers Prev, 3, pp.225~228 (1994)
- Wang A, "Serum urate, genetic variation, and prostate cancer risk : Atherosclerosis Risk in Communities(ARIC)study", Cancer Epidemiol Biomarkers Prev, 28, pp.1259~1261 (2019)
- Wang W, "Increased risk of cancer in relation to gout : a review of three prospective cohort studies with 50358 subjects", Mediators Inflamm, 2015, pp.680853~ (2015)
- Battelli MG, "Xanthine oxidoreductase in cancer : more than a differentiation marker", Cancer Med, 5, pp.546~557 (2016)
- Fini MA, "Contribution of uric acid to cancer risk, recurrence, and mortality", Clin Transl Med, 1, pp.16~ (2012)
- Sprague BL, "Physical activity, white blood cell count, and lung cancer risk in a prospective cohort study", Cancer Epidemiol Biomarkers Prev, 17, pp.2714~2722 (2008)
- Umeki Y, "Serum albumin and cerebro-cardiovascular mortality during a 15-year study in a community-based cohort in Tanushimaru, a cohort of the seven countries study", Intern Med, 55, pp.2917~2925 (2016)
- Lim JE, "Combined effects of smoking and bilirubin levels on the risk of lung cancer in Korea : the Severance cohort study", PLoS One, 9, pp.e103972~ (2014)
- Horsfall LJ, "Serum bilirubin and risk of respiratory disease and death", JAMA, 305, pp.691~697 (2011)
- Horsfall LJ, "Genetically raised serum bilirubin levels and lung cancer : a cohort study and Mendelian randomisation using UK Biobank", Thorax, 75, pp.955~964 (2020)
- Vitek L, "Association between plasma bilirubin and mortality", Ann Hepatol, 18, pp.379~385 (2019)
- Temme EH, "Serum bilirubin and 10-year mortality risk in a Belgian population", Cancer Causes Control, 12, pp.887~894 (2001)
- Maruhashi T, "Bilirubin and endothelial function", J Atheroscler Thromb, 26, pp.688~696 (2019)