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Metabolic Risk Profile and Cancer in Korean Men and Women

윤석준|서혜영|김동우|김아림|김은정|고슬기
대한예방의학회 (The Korean Society For Preventive Medicine)|2016.05|예방의학회지 (Journal of Preventive Medicine and Public Health)|제49권 제3호|pp. 143-152

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참고문헌

키워드

Cohort studiesMetabolic syndromeRisk factorsNeoplasms
주제분류예방의학/직업환경의학

초록

Objectives: Metabolic syndrome is a cluster of risk factors for type 2 diabetes mellitus and cardiovascular disease. Associations between metabolic syndrome and several types of cancer have recently been documented. Methods: We analyzed the sample cohort data from the Korean National Health Insurance Service from 2002, with a follow-up period extending to 2013. The cohort data included 99 565 individuals who participated in the health examination program and whose data were therefore present in the cohort database. The metabolic risk profile of each participant was assessed based on obesity, high serum glucose and total cholesterol levels, and high blood pressure. The occurrence of cancer was identified using Korean National Health Insurance claims data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for age group, smoking status, alcohol intake, and regular exercise. Results: A total of 5937 cases of cancer occurred during a mean follow-up period of 10.4 years. In men with a high-risk metabolic profile, the risk of colon cancer was elevated (HR, 1.40; 95% CI, 1.14 to 1.71). In women, a high-risk metabolic profile was associated with a significantly increased risk of gallbladder and biliary tract cancer (HR, 2.05; 95% CI, 1.24 to 3.42). Non-significantly increased risks were observed in men for pharynx, larynx, rectum, and kidney cancer, and in women for colon, liver, breast, and ovarian cancer. Conclusions: The findings of this study support the previously suggested association between metabolic syndrome and the risk of several cancers. A high-risk metabolic profile may be an important risk factor for colon cancer in Korean men and gallbladder and biliary tract cancer in Korean women.

Abstract

Objectives: Metabolic syndrome is a cluster of risk factors for type 2 diabetes mellitus and cardiovascular disease. Associations between metabolic syndrome and several types of cancer have recently been documented. Methods: We analyzed the sample cohort data from the Korean National Health Insurance Service from 2002, with a follow-up period extending to 2013. The cohort data included 99 565 individuals who participated in the health examination program and whose data were therefore present in the cohort database. The metabolic risk profile of each participant was assessed based on obesity, high serum glucose and total cholesterol levels, and high blood pressure. The occurrence of cancer was identified using Korean National Health Insurance claims data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for age group, smoking status, alcohol intake, and regular exercise. Results: A total of 5937 cases of cancer occurred during a mean follow-up period of 10.4 years. In men with a high-risk metabolic profile, the risk of colon cancer was elevated (HR, 1.40; 95% CI, 1.14 to 1.71). In women, a high-risk metabolic profile was associated with a significantly increased risk of gallbladder and biliary tract cancer (HR, 2.05; 95% CI, 1.24 to 3.42). Non-significantly increased risks were observed in men for pharynx, larynx, rectum, and kidney cancer, and in women for colon, liver, breast, and ovarian cancer. Conclusions: The findings of this study support the previously suggested association between metabolic syndrome and the risk of several cancers. A high-risk metabolic profile may be an important risk factor for colon cancer in Korean men and gallbladder and biliary tract cancer in Korean women.

참고문헌 (37)

  1. Alberti KG, "Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation", Diabet Med, 15(7), pp.539~553 (1998)
  2. Alberti KG, "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity", Circulation, 120(16), pp.1640~1645 (2009)
  3. Cornier MA, "The metabolic syndrome", Endocr Rev, 29(7), pp.777~822 (2008)
  4. Cameron AJ, "The metabolic syndrome: prevalence in worldwide populations", Endocrinol Metab Clin North Am, 33(2), pp.351~375 (2004)
  5. Kassi E, "Metabolic syndrome: definitions and controversies", BMC Med, 9, pp.48~ (2011)
  6. Mozumdar A, "Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999-2006", Diabetes Care, 34(1), pp.216~219 (2011)
  7. Lim S, "Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007", Diabetes Care, 34(6), pp.1323~1328 (2011)
  8. Misra A, "Obesity and the metabolic syndrome in developing countries", J Clin Endocrinol Metab, 93(11 Suppl 1), pp.S9~S30 (2008)
  9. Esposito K, "Metabolic syndrome and risk of cancer: a systematic review and meta-analysis", Diabetes Care, 35(11), pp.2402~2411 (2012)
  10. Stocks T, "Metabolic risk score and cancer risk: pooled analysis of seven cohorts", Int J Epidemiol, 44(4), pp.1353~1363 (2015)
  11. Jinjuvadia R, "The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis", J Clin Gastroenterol, 48(2), pp.172~177 (2014)
  12. Esposito K, "Colorectal cancer association with metabolic syndrome and its components: a systematic review with meta-analysis", Endocrine, 44(3), pp.634~647 (2013)
  13. Bjørge T, "Metabolic syndrome and breast cancer in the Me-Can (metabolic syndrome and cancer) project", Cancer Epidemiol Biomarkers Prev, 19(7), pp.1737~1745 (2010)
  14. Osaki Y, "Metabolic syndrome and incidence of liver and breast cancers in Japan", Cancer Epidemiol, 36(2), pp.141~147 (2012)
  15. Shebl FM, "Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China", Br J Cancer, 105(9), pp.1424~1429 (2011)
  16. Jee SH, "Body mass index and cancer risk in Korean men and women", Int J Cancer, 123(8), pp.1892~1896 (2008)
  17. Jee SH, "Fasting serum glucose level and cancer risk in Korean men and women", JAMA, 293(2), pp.194~202 (2005)
  18. Kitahara CM, "Total cholesterol and cancer risk in a large prospective study in Korea", J Clin Oncol, 29(12), pp.1592~1598 (2011)
  19. Lee JS, "Metabolic syndrome and cancer-related mortality among Korean men and women", Ann Oncol, 21(3), pp.640~645 (2010)
  20. Lee J, "Cohort profile: the National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea", Int J Epidemiol (2016)[DOI]
  21. "The Asian-Pacific perspective: redefining obesity and its treatment" (2000)[URL]
  22. Genuth S, "Follow-up report on the diagnosis of diabetes mellitus", Diabetes Care, 26(11), pp.3160~3167 (2003)
  23. "National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cho-lesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report", Circulation, 106(25), pp.3143~3421 (2002)
  24. Borena W, "A prospective study on metabolic risk factors and gallbladder cancer in the metabolic syndrome and cancer (Me-Can) collaborative study", PLoS One, 9(2), pp.e89368~ (2014)
  25. Kim BC, "Association of colorectal adenoma with components of metabolic syndrome", Cancer Causes Control, 23(5), pp.727~735 (2012)
  26. Lee GE, "Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men", Obesity (Silver Spring), 16(6), pp.1434~1439 (2008)
  27. Esposito K, "Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis", Menopause, 20(12), pp.1301~1309 (2013)
  28. Agnoli C, "Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre Italian cohort", PLoS One, 10(6), pp.e0128891~ (2015)
  29. Mendonça FM, "Metabolic syndrome and risk of cancer: which link", Metabolism, 64(2), pp.182~189 (2015)
  30. Giovannucci E, "Metabolic syndrome, hyperinsulinemia, and colon cancer: a review", Am J Clin Nutr, 86(3), pp.s836~s842 (2007)
  31. Wang YY, "Association between adenomas of rectosigmoid colon and metabolic syndrome features in a Chinese population", J Gastroenterol Hepatol, 20(9), pp.1410~1415 (2005)
  32. Chen LY, "Metabolic syndrome and gallstone disease", World J Gastroenterol, 18(31), pp.4215~4220 (2012)
  33. Stocks T, "Cohort profile: the metabolic syndrome and cancer project (Me-Can)", Int J Epidemiol, 39(3), pp.660~667 (2010)
  34. 송선옥, "Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System", Diabetes and Metabolism Journal, 38(5), pp.395~403 (2014), 대한당뇨병학회[DOI]
  35. 정규원, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012", Cancer Research and Treatment, 47(2), pp.127~141 (2015), 대한암학회[DOI]
  36. Seo HJ, "A comparison of the cancer incidence rates between the national cancer registry and insurance claims data in Korea", Asian Pac J Cancer Prev, 13(12), pp.6163~6168 (2012)
  37. "DB detail and payment of fee"[URL]

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