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Differences in the Impact of Obesity and Metabolic Unhealthiness on the Risk of Gallbladder Polyp

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Purpose: Differences in the impact of obesity and metabolic health status on the risk of gallbladder polyp (GBP) remain uncer tain. Herein, we aimed to compare the risk of GBP ≥5 mm among individuals with different phenotypes based on obesity and metabolic health status. Materials and Methods: A cohort of 253485 asymptomatic adults who underwent abdominal ultrasonography screening were categorized into the following four groups according to obesity and metabolic health status: 1) metabolically healthy non-obese (MHNO), 2) metabolically unhealthy and non-obese (MUNO), 3) metabolically healthy but obese (MHO), and 4) metabolically unhealthy obese (MUO). Results: The prevalences of GBP ≥5 mm were 2.4%, 3.1%, 3.7%, and 4.0% in the MHNO, MUNO, MHO, and MUO groups, respec tively. The multivariable-adjusted odds ratio (OR) values for prevalence of GBP ≥5 mm by comparing the MUNO, MHO, and MUO with the MHNO group were 1.11 [95% confidence interval (CI), 1.04–1.19], 1.30 (95% CI, 1.15–1.47), and 1.37 (95% CI, 1.28–1.45), respectively. The risk of GBP ≥5 mm in the MHO group was significantly higher than that in the MUNO group, but not signifi cantly different from that in the MUO group. Conclusion: Obesity and metabolic unhealthiness appear to be independent risk factors for the prevalence of GBP, and the im pact of obesity is greater than that of metabolic unhealthiness, suggesting that maintaining both normal weight and metabolic health may help reduce the risk of GBP.

Abstract

Purpose: Differences in the impact of obesity and metabolic health status on the risk of gallbladder polyp (GBP) remain uncer tain. Herein, we aimed to compare the risk of GBP ≥5 mm among individuals with different phenotypes based on obesity and metabolic health status. Materials and Methods: A cohort of 253485 asymptomatic adults who underwent abdominal ultrasonography screening were categorized into the following four groups according to obesity and metabolic health status: 1) metabolically healthy non-obese (MHNO), 2) metabolically unhealthy and non-obese (MUNO), 3) metabolically healthy but obese (MHO), and 4) metabolically unhealthy obese (MUO). Results: The prevalences of GBP ≥5 mm were 2.4%, 3.1%, 3.7%, and 4.0% in the MHNO, MUNO, MHO, and MUO groups, respec tively. The multivariable-adjusted odds ratio (OR) values for prevalence of GBP ≥5 mm by comparing the MUNO, MHO, and MUO with the MHNO group were 1.11 [95% confidence interval (CI), 1.04–1.19], 1.30 (95% CI, 1.15–1.47), and 1.37 (95% CI, 1.28–1.45), respectively. The risk of GBP ≥5 mm in the MHO group was significantly higher than that in the MUNO group, but not signifi cantly different from that in the MUO group. Conclusion: Obesity and metabolic unhealthiness appear to be independent risk factors for the prevalence of GBP, and the im pact of obesity is greater than that of metabolic unhealthiness, suggesting that maintaining both normal weight and metabolic health may help reduce the risk of GBP.

참고문헌 (37)

  1. Segawa K, "Prevalence of gallbladder polyps among apparently healthy Japanese : ultrasonographic study", Am J Gastroenterol, 87, pp.630~633 (1992)
  2. 이유진, "Shifting Prevalence of Gallbladder Polyps in Korea", Journal of Korean Medical Science, 29(9), pp.1247~1252 (2014), 대한의학회
  3. Lee KF, "Polypoid lesions of the gallbladder", Am J Surg, 188, pp.186~190 (2004)
  4. Kwon OS, "Are there modifiable risk factors affecting the prevalence of gallbladder polyps or those 5 mm or larger? A retrospective cross-sectional study", Medicine(Baltimore), 100, pp.e27115~ (2021)
  5. Myers RP, "Gallbladder polyps : epidemiology, natural history and management", Can J Gastroenterol, 16, pp.187~194 (2002)
  6. Larsson SC, "Obesity and the risk of gallbladder cancer : a meta-analysis", Br J Cancer, 96, pp.1457~1461 (2007)
  7. Bandera EV, "The use and interpretation of anthropometric measures in cancer epidemiology : a perspective from the world cancer research fund international continuous update project", Int J Cancer, 139, pp.2391~2397 (2016)
  8. Li ZM, "The association between BMI and gallbladder cancer risk : a meta-analysis", Oncotarget, 7, pp.43669~43679 (2016)
  9. 조희범, "Is the Prevalence of Gallbladder Polyp Different between Vegetarians and General Population?", 대한소화기학회지, 66(5), pp.268~273 (2015), 대한소화기학회
  10. Yamin Z, "Risk factors of gallbladder polyps formation in East Asian population : a meta-analysis and systematic review", Asian J Surg, 43, pp.52~59 (2020)
  11. 박은정, "Association between Metabolic Syndrome and Gallbladder Polyps in Healthy Korean Adults", Journal of Korean Medical Science, 28(6), pp.876~880 (2013), 대한의학회
  12. Seon Hee Lim, "Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?", Gut and Liver, 1(2), pp.138~144 (2007), 거트앤리버 소화기연관학회협의회
  13. Hossain P, "Obesity and diabetes in the developing world--a growing challenge", N Engl J Med, 356, pp.213~215 (2007)
  14. Sims EA, "Are there persons who are obese, but metabolically healthy?", Metabolism, 50, pp.1499~1504 (2001)
  15. Brochu M, "What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?", J Clin Endocrinol Metab, 86, pp.1020~1025 (2001)
  16. Primeau V, "Characterizing the profile of obese patients who are metabolically healthy", Int J Obes(Lond), 35, pp.971~981 (2011)
  17. Wildman RP, "The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering : prevalence and correlates of 2 phenotypes among the US population(NHANES 1999-2004)", Arch Intern Med, 168, pp.1617~1624 (2008)
  18. Chang Y, "Metabolically healthy obesity and development of chronic kidney disease : a cohort study", Ann Intern Med, 164, pp.305~312 (2016)
  19. Chang Y, "Alcoholic and nonalcoholic fatty liver disease and liver-related mortality : a cohort study", Am J Gastroenterol, 114, pp.620~629 (2019)
  20. Craig CL, "International physical activity questionnaire : 12-country reliability and validity", Med Sci Sports Exerc, 35, pp.1381~1395 (2003)
  21. Wen CP, "Are Asians at greater mortality risks for being overweight than Caucasians? Redefining obesity for Asians", Public Health Nutr, 12, pp.497~506 (2009)
  22. Alberti KG, "Harmonizing the metabolic syndrome : a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;International Atherosclerosis Society; and International Association for the Study of Obesity", Circulation, 120, pp.1640~1645 (2009)
  23. Lee S, "Cut-off points of waist circumference for defining abdominal obesity in the Korean population", Korean J Obes, 15, pp.1~9 (2006)
  24. Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults", Diabetes Res Clin Pract, 75, pp.72~80 (2007)
  25. Grundy SM, "Diagnosis and management of the metabolic syndrome : an American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
  26. Collett JA, "Gallbladder polyps : prospective study", J Ultrasound Med, 17, pp.207~211 (1998)
  27. Jun Kyu Lee, "Visceral Obesity Is Associated with Gallbladder Polyps", Gut and Liver, 10(1), pp.133~139 (2016), 거트앤리버 소화기연관학회협의회
  28. 도재혁, "Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population", Yonsei Medical Journal, 57(6), pp.1370~1375 (2016), 연세대학교의과대학[DOI]
  29. Calle EE, "Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. S. adults", N Engl J Med, 348, pp.1625~1638 (2003)
  30. Ali TA, "Prevalence and risk factors of gallbladder polyps in primary health care centers among patients examined by abdominal ultrasonography in Qatar : a case-control study", Qatar Med J, 2021, pp.48~ (2021)
  31. Chen CY, "Risk factors for gallbladder polyps in the Chinese population", Am J Gastroenterol, 92, pp.2066~2068 (1997)
  32. Mao YS, "Prevalence and risk factors of gallbladder polypoid lesions in Chinese petrochemical employees", World J Gastroenterol, 19, pp.4393~4399 (2013)
  33. Kim TJ, "Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia", Sci Rep, 7, pp.9011~ (2017)
  34. Karelis AD, "Metabolically healthy but obese individuals", Lancet, 372, pp.1281~1283 (2008)
  35. Kim NH, "Impact of obesity and metabolic abnormalities on the risk of metachronous colorectal neoplasia after polypectomy in men", J Gastroenterol Hepatol, 34, pp.1504~1510 (2019)
  36. 권우일, "Clinicopathologic Features of Polypoid Lesions of the Gallbladder and Risk Factors of Gallbladder Cancer", Journal of Korean Medical Science, 24(3), pp.481~487 (2009), 대한의학회
  37. Yu Z, "Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism", Lipids Health Dis, 20, pp.26~ (2021)

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