Alternative chromatographic method for the assay test of terbutaline and salbutamol using ionic liquid assisted aqueous mobile phase
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.
Abstract
Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.
참고문헌 (20)
- Y. Gaber, , Green Chem, 13, pp.2021~2025 (2011)
- A. Rios, , Trends Anal. Chem, 43, pp.174~188 (2013)
- F. T. G. van den Brink, , Trends Anal. Chem, 70, pp.40~49 (2015)
- F. Pena-Pereira, , Trends Anal. Chem, 29, pp.617~628 (2010)
- H. M. Mohamed, , Trends Anal. Chem, 66, pp.176~192 (2015)
- M. Tobiszewski, , Anal. Methods, 8, pp.2993~2999 (2016)
- A. Berthod, , J. Chromatogr. A, 1184, pp.6~18 (2008)
- A. Romero, , J. Hazard. Mater, 151, pp.268~273 (2008)
- S. H. Hansen, "Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques, and Mass Spectrometry" (2015), Wiley
- J. W. Dolan, , LCGC Eur, 21, pp.258~263 (2008)
- L. He, , J. Chromatogr. A, 1007, pp.39~45 (2003)
- X. Xiaohua, , Anal. Chim. Acta, 519, pp.207~211 (2004)
- 서준혁, "Determination of Thiamine in Pharmaceutical Preparations by Reverse Phase Liquid Chromatography Without Use of Organic Solvent", Bulletin of the Korean Chemical Society, 34(6), pp.1745~1750 (2013), 대한화학회[DOI]
- 서나래, "Determination of urazamide in pharmaceutical preparation with room temperature ionic liquid", Archives of Pharmacal Research, 40(3), pp.364~372 (2017), 대한약학회
- J. H. Suh, , J. Chromatogr. A, 1496, pp.174~179 (2017)
- D. P. Tashkin, , Respir. Res, 11, pp.149~ (2010)
- The United States Pharmacopeial Convention, "The United States Pharmacopeia USP 39 NF 34", ~ (2016)
- Medicines & Healthcare Products Regulatory Agency, "British Pharmacopoeia" (2013)
- ICH, "ICH Harmonised Tripartite Guideline Q2(R1):Validation of Analytical Procedures", ICH, ~ (2005)
- D. V. McCalley, , J. Chromatogr. A, 1217, pp.858~880 (2010)