Monolithic 칼럼을 이용한 뇨 중 유기용매 대사체의 신속한 HPLC 동시 분석
Rapid and simultaneous ddetermination of metabolites of organic solvents in human urine by high-performance liquid chromatography using a monolithic column
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Abstract
urinary metabolites of organic solvents, mandelic acid, hippuric acid, phenylglyoxylic acid, ortho-, meta- andpara-methylhippuric acid, using a monolithic column. The mobile phase was composed of tetrabutylamoniumbromide as ion-pairing reagent with a flow rate of 2.4 mL/min. The total run time was less than 2.5 min forall six analytes. Good linearities were obtained for all the metabolites with correlation coefficients above 0.9993.Intra-day precision, accuracy and inter-day precision was 0.01~7.32%, 83.9~116.3% and 0.01~7.16%,. Corresponding authorPhone : +82-(0)2-820-5601 Fax : +82-(0)2-3280-5596E-mail: youmjr@cau.ac.kr434 .......................Analytical Science & Technologyrespectively. The method was validated and confirmed by quantification of the quality assurance samples ofIndustrial Safety and Health Research Institute, Korea Occupational Safety and Health Agency.
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