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Identification of novel Leishmania major antigens that elicit IgG2a response in resistant and susceptible mice

Majid Zeinali|Sussan K. Ardestani|Amina Kariminia|Mohammad Reza Mohammadi
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2006.03|Parasites, Hosts and Diseases|제44권 제1호|pp. 43-48

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참고문헌

주제분류예방의학/직업환경의학

초록

Abstract

Experimental murine models with high, intermediate and low levels of genetically based susceptibility toLeishmania major are increasing non-comparative studies on immune responses against isolated antigens of L. majorin differentmurine strains. The aim of the present study was to find out whether there is an antigen that can induce protectiveimmune response in resistant and susceptible murine strains. To do that, crude antigenic extract of procyclic andL. majorwas prepared and subjected to SDS-PAGE electrophoresis. Western-blottingwas used to search for antigen(s) capable of raising high antibody level of IgG2a versus IgG1 in the sera of bothinfected resistant and susceptible strains. Two novel antigens from metacyclic promastigotes of L. major(140 andantigens also reacted with IgG antibody of cutaneous leishmaniasis patients. We confirm that 140 and 152 kDa pro-teins of L. majorpromastigotes are inducing IgG production in mice and humans.

참고문헌 (15)

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관련 논문AI추천

Purification and biochemical characterizationof two novel antigens from Leishmania major promastigotesAmina Kariminia, Majid Zeinali, Sussan K. Ardestani대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2007 · 제45권 제4호Leishmania tropica infection, in comparison toLeishmania major, induces lower delayed type hypersensitivityin BALB/c miceDavood Iravani, Hamid Mahmoudzadeh-Niknam, Simin Sadat Kiaei대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2007 · 제45권 제2호Production of nitric oxide by murine macrophages induced by lipophosphoglycan of Leishmania majorAmina Kariminia, Gholamreza Kavoosi, Sussan K. Ardestani, Zahra Tavakoli대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2006 · 제44권 제1호Vaccination against Murine Toxoplasmosis Using Recombinant Toxoplasma gondii SAG3 Antigen Alone or in Combination with Quil A남호우, 신대완, 안명희, 이영하, 이재호연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제3호The Route of Leishmania tropica Infection Determines Disease Outcome and Protection against Leishmania major in BALB/c MiceAli Najafy, Firoozeh Abrishami, Ghader Khalili, Hamid Mahmoudzadeh-Niknam, Vahid Khaze대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2013 · 제51권 제1호Leishmania Vaccines: the Current Situation with Its Promising Aspect for the FutureRasit Dinc대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2022 · 제60권 제6호

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