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Effects of combined therapy with thalidomide and glucantime on leishmaniasis induced by Leishmania major in BALB/c mice

Amina Kariminia|Ghassem Solgi|Khossro Abdi|Majid Darabi|Behnaz Ghareghozloo
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2006.03|Parasites, Hosts and Diseases|제44권 제1호|pp. 55-61

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참고문헌

주제분류예방의학/직업환경의학

초록

Abstract

For treating Leishmania major infection in BALB/c mice, we used thalidomide in conjunction with glucan-time. Groups of mice were challenged with 5 × 103 metacyclic promastigotes of L. majorsubcutaneously. A weekafter the challenge, drug treatment was started and continued for 12 days. Thalidomide was orally administrated 30mg/kg/day and glucantime was administrated intraperitoneally (200 mg/kg/day). It was shown that the combined ther-apy is more effective than single therapies with each one of the drugs since the foot pad swelling in the group of micereceived thalidomide and glucantime was significantly decreased (0.9 ± 0.2 mm) compared to mice treated with eitherglucantime, thalidomide, or carrier alone (1.2 ± 0.25, 1.4 ± 0.3, and 1.7 ± 0.27 mm, respectively). Cytokine studyshowed that the effect of thalidomide was not dependent on IL-12; however, it up-regulated IFN-γand down-regulatedIL-10 production. Conclusively, thalidomide seems promising as a conjunctive therapy with antimony in murine modelof visceral leishmaniasis.

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