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Trichomonas vaginalis and trichomoniasis in the Republic of Korea

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Abstract

Vaginal trichomoniasis, caused by Trichomonas vaginalis, is the most common sexually transmitted dis-10.4% of women complaining of vaginal symptoms and signs were found to be infected with T. vaginalis. However,despite its high prevalence, the pathogenesis of T. vaginalisinfection has not been clearly characterized althoughneutrophil infiltration is considered to be primarily responsible for the cytologic changes associated with this infection.secretory product that have a chemotactic effect on neutrophils, and that these neutrophils are further stimulated byT. vaginalisto produce chemokines like IL-8 and GRO-α, which further promote neutrophil recruitment and chemo-taxis. Thus, neutrophil accumulation is believed to maintain or aggravate inflammation. However, enhanced neutrophilapoptosis induced by live T. vaginalisimportant component of host defense against T. vaginalisinfection. For example, mouse macrophages alone andthose activated by lymphokines or nitric oxide are known to be involved in the extracellular killing of T. vaginalis. Inthe host, T. vaginalisuses a capping phenomenon to cleave host immunoglobulins with proteinases and thus escapereaction (PCR) technique using primers based on a repetitive sequence cloned from T. vaginalis(TV-E650), andfound that the method enables the detection of T. vaginalisat concentrations as low as 1 cell per PCR mixture.

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