Expression of TNF-α and IL-1β in Splenic Dendritic Cells and Their Serum Levels in Mouse Sparganosis
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초록
Sparganosis is a tissue invading helminthiasis infecting intermediate hosts, including humans. Strong immune responses are expected to occur in early phases of infection. Thus, we investigated cytokine expressions in splenic dendritic cells and in sera after experimental infection of mice. In splenic dendritic cells, TNF-α and IL-1β expression peaked at week 1 and week 3 post-infection (PI), respectively, and also early phase (week 2 PI) depressed cytokine expression was noticed. Serum IL-1β concentration increased significantly at week 2 PI and peaked at week 6 PI, and that of TNF-α peaked at week 6 PI. These results showed that pro-inflammatory cytokines, TNF-α and IL-1β, are chronologically regulated in mouse sparganosis.
Abstract
Sparganosis is a tissue invading helminthiasis infecting intermediate hosts, including humans. Strong immune responses are expected to occur in early phases of infection. Thus, we investigated cytokine expressions in splenic dendritic cells and in sera after experimental infection of mice. In splenic dendritic cells, TNF-α and IL-1β expression peaked at week 1 and week 3 post-infection (PI), respectively, and also early phase (week 2 PI) depressed cytokine expression was noticed. Serum IL-1β concentration increased significantly at week 2 PI and peaked at week 6 PI, and that of TNF-α peaked at week 6 PI. These results showed that pro-inflammatory cytokines, TNF-α and IL-1β, are chronologically regulated in mouse sparganosis.
참고문헌 (13)
- Cho SY, "Some aspects of human sparganosis", Korean J Parasitol, 13, pp.60~77 (1975)
- Banchereau J, "Immunobiology of dendritic cells", Annu Rev Immunol, 18, pp.767~811 (2000)
- Fearon DT, "The instructive role of innate immunity in the acquired immune response", Science, 272, pp.50~53 (1996)
- Medzhitov R, "Innate immunity: the virtues of a nonclonal system of recognition", Cell, 91, pp.295~298 (1997)
- Tracey KJ, "Tumor necrosis factor, other cytokines and disease", Ann Rev Cell Biol, 9, pp.317~343 (1993)
- Tincani A, "Inflammatory molecules: a target for treatment of systemic autoimmune diseases", Autoimmun Rev, 7, pp.1~7 (2007)
- Dinarello CA, "Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings", J Biol Regul Homeost Agents, 11, pp.91~103 (1997)
- Ulevitch RJ, "Recognition of gram-negative bacteria and endotoxin by the innate immune system", Curr Opin Immunol, 11, pp.19~22 (1999)
- Rao UR, "Regulatory cytokines in the lymphatic pathology of athymic mice infected with Brugia malayi", Int J Parasitol, 26, pp.561~565 (1996)
- Biet F, "Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens", J Mol Med, 80, pp.147~162 (2002)
- Eger A, "Pro-inflammatory (IL-1β, IL-18) cytokines and IL-8 chemokine release by PBMC in response to Echinococcus multilocularis metacestode vesicles", Parasite Immunol, 25, pp.103~105 (2003)
- Perona-Wright G, "Dendritic cell activation and function in response to Schistosoma mansoni", Int J Parasitol, 36, pp.711~721 (2006)
- Carvalho L, "Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function", Immunology, 126, pp.28~34 (2009)