가습기 살균제 건강 피해 조사에서 노출 평가 방법 고찰
A Strategy for Exposure Assessment of Humidifier Disinfectant Associated to Health Effects
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참고문헌
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초록
Objectives: The objectives of this study are to describe strategy for exposure assessment of humidifier disinfectant (HD) used in the national program to associate the use of HD with lung injury. Methods: Strategy and method employed to evaluate HD use characteristics were developed to associate health effects including HD associated with lung injury (HDLI). We developed HD-specific questionnaire to assess potential HD exposure, which was consistently used in the national program. Trained environmental health scientists visited the residences of registered subjects and investigated HD use characteristics. Results: Major HD exposure related variables were type of HD brand/s used; HD volume added to the humidifier, frequency of HD addition, and time spent in room/s with the humidifier; duration of HD use in the household in average months/year, weeks/month, and days/week; average sleeping hours in a room with an operating humidifier containing a disinfectant; number of HD brands used and type of HD; average distance of the bed from the humidifier in meters. Conclusions: We concluded that estimated airborne HD concentration was significantly associated with the risk of HDLI.
Abstract
Objectives: The objectives of this study are to describe strategy for exposure assessment of humidifier disinfectant (HD) used in the national program to associate the use of HD with lung injury. Methods: Strategy and method employed to evaluate HD use characteristics were developed to associate health effects including HD associated with lung injury (HDLI). We developed HD-specific questionnaire to assess potential HD exposure, which was consistently used in the national program. Trained environmental health scientists visited the residences of registered subjects and investigated HD use characteristics. Results: Major HD exposure related variables were type of HD brand/s used; HD volume added to the humidifier, frequency of HD addition, and time spent in room/s with the humidifier; duration of HD use in the household in average months/year, weeks/month, and days/week; average sleeping hours in a room with an operating humidifier containing a disinfectant; number of HD brands used and type of HD; average distance of the bed from the humidifier in meters. Conclusions: We concluded that estimated airborne HD concentration was significantly associated with the risk of HDLI.
참고문헌 (7)
- Sang-Bum Hong, "A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome", Thorax, 69(8), pp.694~702 (2014), BMJ[DOI]
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- Park DU, "Association of high-level humidifier disinfectant exposure with lung injury in preschool children", Sci Total Environ, 616, pp.855~862 (2018)
- D. U. Park, "Estimating retrospective exposure of household humidifier disinfectants", Indoor Air, 25(6), pp.631~640 (2015), Wiley[DOI]
- Analytical results of the chemical components of various humidifier disinfectant brands from KCDC's parliamentary inspection, "Korean Centers for Disease Controla and Prevention", Department of Epidemiology Research, ~ (2011)
- Dong-Uk Park, "Relationship between Exposure to Household Humidifier Disinfectants and Risk of Lung Injury: A Family-Based Study", PLOS ONE, 10(5), pp.e0124610~ (2015), Public Library of Science (PLoS)[DOI]
- Domyung Paek, "Nationwide Study of Humidifier Disinfectant Lung Injury in South Korea, 1994–2011. Incidence and Dose–Response Relationships", Annals of the American Thoracic Society, 12(12), pp.1813~1821 (2015), American Thoracic Society[DOI]