Association of Time Interval From Surgery to Postoperative Radiation Therapy With Survival for Patients With Head and Neck Cancer
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Background and Objectives Oncologic effect of initiating postoperative radiotherapy(PORT) in adherance with the National Comprehensive Cancer Network Guidelines remainsuncertain. This study aimed to reassess the impact of time of initiating PORT over 6 weeks onsurvival. Subjects and Method Patients were dichotomized into groups according to the time of ini-tiation, those that initiated PORT ≤6 weeks and those that initiated PORT >6 weeks postoper-atively. The Kaplan-Meier, univariate, and multivariate analyses were then conducted. Out-come measures were overall survival (OS) and progression-free survival (PFS). Results OS rates at 5 years for the group that initiated PORT ≤6 weeks and those that initi-ated PORT >6 weeks were 86.3% and 72.9%, respectively (log-rank p=0.26). PFS rates at 5 yearsfor the group of PORT ≤6 and for the group of PORT >6 weeks were 65.6% and 65.9%, re-spectively (log-rank p=0.95). Conclusion In this study, there was no statistical difference in OS and PFS rate betweengroups that began initiation of PORT ≤6 and those that began >6 weeks. In the future, retro-spective studies with more patients will be needed to further confirm our observation from this study.
Abstract
Background and Objectives Oncologic effect of initiating postoperative radiotherapy(PORT) in adherance with the National Comprehensive Cancer Network Guidelines remainsuncertain. This study aimed to reassess the impact of time of initiating PORT over 6 weeks onsurvival. Subjects and Method Patients were dichotomized into groups according to the time of ini-tiation, those that initiated PORT ≤6 weeks and those that initiated PORT >6 weeks postoper-atively. The Kaplan-Meier, univariate, and multivariate analyses were then conducted. Out-come measures were overall survival (OS) and progression-free survival (PFS). Results OS rates at 5 years for the group that initiated PORT ≤6 weeks and those that initi-ated PORT >6 weeks were 86.3% and 72.9%, respectively (log-rank p=0.26). PFS rates at 5 yearsfor the group of PORT ≤6 and for the group of PORT >6 weeks were 65.6% and 65.9%, re-spectively (log-rank p=0.95). Conclusion In this study, there was no statistical difference in OS and PFS rate betweengroups that began initiation of PORT ≤6 and those that began >6 weeks. In the future, retro-spective studies with more patients will be needed to further confirm our observation from this study.
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