Characterization and function of human Ly-6/uPAR molecules
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Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy. [BMB Reports 2012; 45(11): 595-603]
Abstract
Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy. [BMB Reports 2012; 45(11): 595-603]
참고문헌 (100)
- McKenzie, I. F., "Lymphocyte antigens: Ly-4, Ly-6, and Ly-7", Transplant Proc., 9, pp.667~669 (1977)
- LeClair, K. P., "Murine Ly-6 multigene family is located on chromosome 15", Proc. Natl. Acad. Sci. U.S.A., 84, pp.1638~1642 (1987)
- Gumley, T. P., "Tissue expression, structure and function of the murine Ly-6 family of molecules", Immunol. Cell. Biol., 73, pp.277~296 (1995)
- Li, S. H., "SSLP-1, a secreted Ly-6 protein purified from mouse seminal vesicle fluid", Reproduction, 132, pp.493~500 (2006)
- Havran, W. L., "Characterization of an anti- Ly-6 monoclonal antibody which defines and activates cytolytic T lymphocytes", J. Immunol., 140, pp.1034~1042 (1988)
- Davies, A., "CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells", J. Exp. Med., 170, pp.637~654 (1989)
- Fleming, T. J., "Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins", J. Immunol., 150, pp.5379~5390 (1993)
- Meri, S., "Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers", Immunology, 71, pp.1~9 (1990)
- Chang, C. P., "Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59", J. Biol. Chem., 269, pp.26424~26430 (1994)
- Treon, S. P., "Treatment of multiple myeloma by antibody mediated immunotherapy and induction of myeloma selective antigens", Ann. Oncol., 11(Suppl 1), pp.107~111 (2000)
- Naderi, S., "CD2-mediated CD59 stimulation in keratinocytes results in secretion of IL-1alpha, IL-6, and GM-CSF: implications for the interaction of keratinocytes with intraepidermal T lymphocytes", Int. J. Mol. Med., 3, pp.609~614 (1999)
- Li, B., "The effects of CD59 gene as a target gene on breast cancer cells", Cell Immunol., 272, pp.61~70 (2011)
- Temerinac, S., "Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera", Blood, 95, pp.2569~2576 (2000)
- Sachs, U. J., "The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)", J. Biol. Chem., 282, pp.23603~23612 (2007)
- Dillon, M., "Expression of the GPI-anchored receptor Prv-1 enhancesthrombopoietin and IL-3-induced proliferation inhematopoietic cell lines", Leuk Res., 32, pp.811~819 (2008)
- Korkmaz, B., "A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors", J. Biol. Chem., 283, pp.35976~35982 (2008)
- Beigneux, A. P., "Glycosylphosphatidylinositol-anchored high-density lipoprotein- binding protein 1 plays a critical role in the lipolytic processing of chylomicrons", Cell Metab., 5, pp.279~291 (2007)
- Davies, B. S., "GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries", Cell Metab., 12, pp.42~52 (2010)
- Quak, J. J., "A 22-kd surface antigen detected by monoclonal antibody E 48 is exclusively expressed in stratified squamous and transitional epithelia", Am. J. Pathol., 136, pp.191~197 (1990)
- Bartelink, H., "Progress in radiotherapy by treatment tailoring in head and neck cancer", Curr. Opin. Oncol., 3, pp.523~528 (1991)
- Nieuwenhuis, E. J., "Assessment and clinical significance of micrometastases in lymph nodes of head and neck cancer patients detected by E48 (Ly-6D) quantitative reverse transcription-polymerase chain reaction", Lab. Invest., 83, pp.1233~1240 (2003)
- Antica, M., "Stem cell antigen2 expression in adult and developing mice", Immunol.Lett., 55, pp.47~51 (1997)
- Noda, S., "Protection from anti-TCR", CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1, J. Exp. Med., pp.1996, 183[DOI]
- Saitoh, S., "Modulation of TCR-mediated signaling pathway by thymic shared antigen-1 (TSA-1)", stem cell antigen-2 (Sca-2), 1995, pp.155, 5574~5581
- Bresson-Mazet, C., "Stem cell antigen 2: a new gene involved in theself-renewal of erythroid progenitors", Cell Prolif., 41, pp.726~738 (2008)
- Horie, M., "Isolation and characterization of a new member of the human Ly6 gene family (LY6H)", Genomics, 53, pp.365~368 (1998)
- de Nooij-van Dalen, A. G., "Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma", Int. J. Cancer, 103, pp.768~774 (2003)
- Lee, J. W., "LY-6K gene: a novel molecular marker for human breast cancer", Oncol. Rep., 16, pp.1211~1214 (2006)
- Ishikawa, N., "Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas", Cancer Res., 67, pp.11601~11611 (2007)
- Matsuda, R., "LY6K is a novel molecular target in bladder cancer on basis of integrate genome- wide profiling", Br. J. Cancer, 104, pp.376~386 (2011)
- Zhang, B., "Serological antibodies against LY6K as a diagnostic biomarker in esophageal squamous cell carcinoma", Biomarkers, 17, pp.372~378 (2012)
- 공현경, "Metastatic effect of LY-6K gene in breast cancer cells", International Journal of Oncology, 35(3), pp.601~607 (2009), Demetrios A. Spandidos Ed. & Pub.
- Suda, T., "Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy", Cancer Sci., 98, pp.1803~1808 (2007)
- Yu, D. H., "PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway", Exp. Cell Res., 312, pp.865~876 (2006)
- Egerod, K. L., "GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue", Mol. Endocrinol., 21, pp.1685~1698 (2007)
- Wurfel, J., "Cloning of the human homologue of the metastasis-associated rat C4.4A", Gene, 262, pp.35~41 (2001)
- Seiter, S., "Upregulation of C4.4A expression during progression of melanoma", J. Invest. Dermatol., 116, pp.344~347 (2001)
- Fletcher, G. C., "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan", Br. J. Cancer, 88, pp.579~585 (2003)
- Paret, C., "C4.4A as a candidate marker in the diagnosis of colorectal cancer", Br. J. Cancer, 97, pp.1146~1156 (2007)
- Hansen, L. V., "Tumour cell expression of C4.4A, a structural homologueof the urokinase receptor, correlates with poorprognosis in non-small cell lung cancer", Lung Cancer, 58, pp.260~266 (2007)
- Hansen, L. V., "Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma", Int. J. Cancer, 122, pp.734~741 (2008)
- Oshiro, R., "C4.4A is associated with tumor budding and epithelial- mesenchymal transition of colorectal cancer", Cancer Sci., 103, pp.1155~1164 (2012)
- Ngora, H., "Membrane-bound and exosomal metastasis-associatedC4.4A promotes migration by associating with thealpha(6)beta(4) integrin and MT1-MMP", Neoplasia, 14, pp.95~107 (2012)
- Zhang, Y., "Identification and characterization of humanLYPD6, a new member of the Ly-6 superfamily", Mol. Biol.Rep., 37, pp.2055~2062 (2010)
- Ni, J., "Cloning and characterization of a human LYPD7, a new member of the Ly-6 superfamily", Mol. Biol. Rep., 36, pp.697~703 (2009)
- Reiter, R. E., "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer", Proc. Natl. Acad. Sci. U.S.A., 95, pp.1735~1740 (1998)
- Argani, P., "Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma", Cancer Res., 61, pp.4320~4324 (2001)
- Amara, N., "Prostate stem cell antigen is overexpressed in human transitional cell carcinoma", Cancer Res., 61, pp.4660~4665 (2001)
- Elsamman, E. M., "The expression of prostate stem cell antigen in human clear cell renal cell carcinoma: a quantitative reverse transcriptase- polymerase chain reaction analysis", BJU Int., 98, pp.668~673 (2006)
- Sakamoto, H., "Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer", Nat. Genet., 40, pp.730~740 (2008)
- Liu, W. K., "Expression of PSCA, PIWIL1, and TBX2 in endometrial adenocarcinoma", Onkologie, 33, pp.241~245 (2010)
- Kawaguchi, T., "Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer", Jpn. J. Clin. Oncol., 40, pp.319~326 (2010)
- Liu, W. K., "Expression of PSCA, PIWIL1 and TBX2 and its correlation with HPV16 infection in formalin-fixed, paraffin-embedded cervical squamous cell carcinoma specimens", Arch. Virol., 155, pp.657~663 (2010)
- Hao, J. Y., "PSCA expression in invasive micropapillary carcinoma of breast", Zhonghua Bing Li Xue Za Zhi, 40, pp.382~386 (2011)
- Geiger, K. D., "The prostate stem cell antigen represents a novel glioma-associated antigen", Oncol Rep., 26, pp.13~21 (2011)
- Bahrenberg, G., "Reduced expression of PSCA, a member of theLY-6 family of cell surface antigens, in bladder, esophagus,and stomach tumors", Biochem. Biophys. Res.Commun., 275, pp.783~788 (2000)
- 이연수, "Prostate Stem Cell Antigen, a Presumable Organ-Dependent Tumor Suppressor Gene, is Down-Regulated in Gallbladder Carcinogenesis", GENES CHROMOSOMES CANCER, 51(1), pp.30~41, WILEY-BLACKWELL
- Wu, X., "Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer", Nat. Genet., 41, pp.991~995 (2009)
- Matsuo, K., "Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese", Int. J. Cancer, 125, pp.1961~1964 (2009)
- Kim, S. Y., "Prostate Stem Cell Antigen Single Nucleotide Polymorphisms Influence Risk of Estrogen Receptor Negative Breast Cancer in Korean Females", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 13(1), pp.41~48 (2012), ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
- Saffran, D. C., "Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts", Proc. Natl. Acad. Sci. U.S.A., 98, pp.2658~2663 (2001)
- Feng, H. C., "Overexpression of prostate stem cell antigen is associated with gestational trophoblastic neoplasia", Histopathology, 52, pp.167~174 (2008)
- Moore, M. L., "Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation", Prostate, 68, pp.139~151 (2008)
- Marra, E., "Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways", BMC Cancer, 10, pp.129~ (2010)
- Shetty, J., "SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6", urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction, 2003, pp.278, 30506~30515
- Adermann, K., "Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6", uPAR protein superfamily, 1999, pp.8, 810~819
- Fischer, J., "Mutations in the gene encoding SLURP-1 in Mal de Meleda", Hum. Mol. Genet, 10, pp.875~880 (2001)
- Tsuji, H., "SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris", Genomics, 81, pp.26~33 (2003)
- Arredondo, J., "Biological effects of SLURP-1 on human keratinocytes", J. Invest. Dermatol., 125, pp.1236~1241 (2005)
- Pettersson, A., "Expression of the endogenous, nicotinic acetylcholine receptor ligand, SLURP-1, in human colon cancer", Auton Autacoid. Pharmacol., 28, pp.109~116 (2008)
- Phan, T. C., "A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts", J. Periodontal. Res., 45, pp.331~336 (2010)
- Tjiu, J. W., "SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda", Br. J. Dermatol., 164, pp.47~53 (2011)
- Arredondo, J., "SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium", J. Cell. Physiol., 208, pp.238~245 (2006)
- Moriwaki, Y., "Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands", Life Sci., 80, pp.2365~2368 (2007)
- Anderson, D. J., "Monoclonal antibodies to human trophoblast and sperm antigens: report of two WHO-sponsored workshops, June 30, 1986--Toronto, Canada", J. Reprod. Immunol., 10, pp.231~257 (1987)
- Herr, J. C., "Biochemical and morphological characterization of the intra-acrosomal antigen SP-10 from human sperm", Biol. Reprod., 42, pp.181~193 (1990)
- Kurth, B. E., "Localization of sperm antigen SP-10 during the sixstages of the cycle of the seminiferous epithelium in man", Biol. Reprod., 44, pp.814~821 (1991)
- Vassalli, J. D., "A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase", J. Cell Biol., 100, pp.86~92 (1985)
- Mondino, A., "Structure and function of the urokinase receptor", Thromb Haemost, 82(Suppl 1), pp.19~22 (1999)
- Schlechte, W., "Examination of the role of the urokinase receptor in human colon cancer mediated laminin degradation", Cancer Res., 49, pp.6064~6069 (1989)
- Del Vecchio, S., "Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: comparison with urokinase levels", Cancer Res., 53, pp.3198~3206 (1993)
- de Vries, T. J., "Plasminogen activa-tors, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression", Am. J. Pathol., 144, pp.70~81 (1994)
- Mohanam, S., "Proteolysis and invasiveness of brain tumors: role of urokinase-type plasminogen activator receptor", J. Neurooncol., 22, pp.153~160 (1994)
- Pedersen, H., "Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue", Cancer Res., 54, pp.4671~4675 (1994)
- Wagner, S. N., "Modulation of urokinase and urokinase receptor gene expression in human renal cell carcinoma", Am. J. Pathol., 147, pp.183~192 (1995)
- Morita, Y., "Expression of urokinase-type plasminogen activator receptor in hepatocellular carcinoma", Hepatology, 25, pp.856~861 (1997)
- Yonemura, Y., "Correlation between expression of urokinase-type plasminogen activator receptor and metastasis in gastric carcinoma", Oncol. Rep., 4, pp.1229~1234 (1997)
- Sier, C. F., "The level of urokinase-type plasminogen activator receptor is increased in serum of ovarian cancer patients", Cancer Res., 58, pp.1843~1849 (1998)
- Schmidt, M., "Increased levels of urokinase receptor in plasma of head and neck squamous cell carcinoma patients", Acta. Otolaryngol., 119, pp.949~953 (1999)
- Nozaki, S., "Inhibition of invasion and metastasis in oral cancer by targeting urokinase- type plasminogen activator receptor", Oral Oncol., 41, pp.971~977 (2005)
- Wang, J., "Expression of urokinase-type plasminogen activator receptor is correlated with metastases of lingual squamous cell carcinoma", Br. J. Oral. Maxillofac. Surg., 44, pp.515~519 (2006)
- Hildenbrand, R., "Amplification of the urokinase-type plasminogen activator receptor (uPAR) gene in ductal pancreatic carcinomas identifies a clinically high-risk group", Am. J. Pathol., 174, pp.2246~2253 (2009)
- Ossowski, L., "Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth", Curr. Opin. Cell Biol., 12, pp.613~620 (2000)
- Nykjaer, A., "Urokinase receptor. An activation antigen in human T lymphocytes", J. Immunol., 152, pp.505~516 (1994)
- Gyetko, M. R., "Function of the urokinase receptor (CD87) in neutrophil chemotaxis", J. Leukoc. Biol., 58, pp.533~538 (1995)
- Pedersen, N., "A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer", J. Clin. Invest., 92, pp.2160~2167 (1993)
- Rigolin, G. M., "Soluble urokinase-type plasminogen activator receptor (suPAR) as an independent factor predicting worse prognosis and extra- bone marrow involvement in multiple myeloma patients", Br. J. Haematol., 120, pp.953~959 (2003)
- Nijziel, M. R., "The prognostic value of the soluble urokinase-type plasminogen activator receptor (s-uPAR) in plasma of breast cancer patients with and without metastatic disease", J. Thromb. Haemost., 1, pp.982~986 (2003)
- Saitou, N., "The neighbor-joining method: a new method for reconstructing phylogenetic trees", Mol. Biol. Evol., 4, pp.406~425 (1987)
- Whelan, S., "A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach", Mol. Biol. Evol., 18, pp.691~699 (2001)
