연령 증가에 따른 dehydroepiandrosterone sulfate와 free testosterone의 농도 변화
Declining concentrations of dehydroepiandrosterone sulfate and free testosterone with advancing age
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목적: 연령이 증가함에 따른 dehydroepiandrosterone sulfate (DHEAS)와 free testosterone (FT)의 혈중농도 변화에 대해 조사하고자 하였다. 연구 방법: 희발 월경이나 무월경 또는 다모증 등 androgen 과다 증상을 제외한 131명의 여성으로부터 채혈하여 방사선면역 측정법을 이용하여 DHEAS와 FT을 측정하였다. P<0.05를 통계적 유의성이 있는 것으로 판단하였다. 결과: 20대 (n=10)의 DHEAS평균은 211.39±33.01 μg/dL, 30대 (n=31)는 127.99±11.79 μg/dL, 40대 (n=57)는 94.30±7.49 μg/dL, 50대 이상 (n=57)은 71.79±5.71 μg/dL이었다 (평균±표준오차, P<0.001). FT농도는 20대에서 3.98±0.94 pg/mL, 30대에서 3.37±0.47 pg/mL, 40대에서 2.68±0.30 pg/mL, 50대 이상은 1.97±0.28 pg/mL이었다 (평균±표준오차, P=0.030). DHEAS의 감소 기울기는 r=-0.48865 (P<0.0001)이었으며, FT의 감소기울기는 r=-0.29334 (P<0.0007)이었다. 결론: DHEAS와 FT 혈중 농도는 연령이 증가함에 따라 감소하고 그 감소 정도는 DHEAS가 FT보다 더 크게 나타났다.
Abstract
Objective: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) or free testosterone (FT) levels and aging. Methods: One hundred and thirty one women without androgen excess symptoms such as oligomenorrhea or amenorrhea or hirsutism were recruited for measuring serum DHEAS, FT levels by radioimmunoassay. A P-value <0.05 was considered to be significant statistically. Results: The levels of DHEAS were 211.39±33.01 μg/dL (twenties, n=10), 127.99±11.79 μg/dL (thirties, n=31), 94.30±7.49 μg/dL (forties, n=57) and 71.79±5.71 μg/dL (over fifties, n=33) respectively (mean±SE, P<0.001). The levels of FT were 3.98±0.94 pg/ml (twenties, n=10), 3.37±0.47 pg/mL (thirties, n=31), 2.68±0.30 pg/mL (forties, n=57) and 1.97±0.28 pg/mL (fifties, n=33) respectively (mean±SE, P=0.030). Mean value declining of DHEAS (r=-0.48865, P<0.0001) was bigger than those of FT (r=-0.29334, P<0.0007). Conclusion: Both DHEAS and FT levels decline with age and DHEAS decreases more steeply than FT.
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