본문 바로가기
KERD
논문KCI 등재

경계성 난소종양 치료의 최신 지견

Current management of borderline ovarian tumor

3

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류산부인과학

초록

경계성 난소종양 치료로는 철저한 외과적 병기설정 이후 정기적인 추적 관찰을 하는 방법이 행해지고 있다. 최근의 경향은 예후가 양호할 것으로 예측되는 젊은 여성 환자들에게 보존적 방법의 치료를 시행하는 것인데, 이러한 보존적 치료의 안전성이 완전히 확립된 것은 아니다. 본 종설은 최근에 발표된 연구들을 중심으로 경계성 난소종양의 치료에 대한 최신 지견을고찰 해 본다. 재발 위험을 가늠하기 위해 외과적 병기설정은 필수적인데, 가임력을 보존하는 수술의 경우라도 자궁절제술과 반대측 난소절제술을 제외한 적절한 외과적 병기설정은 필요하다. 1기 환자의 경우 가임력을 보존하는 수술을 시행할 수 있으며, 그 이상 진행된 환자에게는 근치적 수술이 필요하다. 수술 후 보조화학요법이나 복강경하 병기설정의 역할은 현재까지 확실하지 않다.

Abstract

The mainstream in management of borderline ovarian tumor has been thorough surgical staging and close observation. Recent trends prefer conservative management especially for the young, reproductive aged women due to the good prognosis profile and wide use of laparoscopy, although the safety for oncologic outcome of conservative treatment has not been fully established. The present article updates published literatures respecting management of borderline ovarian tumor. A proper staging procedure is necessary for all the patients to estimate the risk of recurrence. Fertility-sparing surgery is a tolerable option in young patients with stage I disease. Patients with advanced-stage disease or who are finished childbearing are treated with radical surgery. The roles of adjuvant chemotherapy or laparoscopic staging are not definite up to now.

참고문헌 (45)

  1. Tinelli R, "Conservative surgery for borderline ovarian tumors: a review", Gynecol Oncol, 100, pp.185~191 (2006)
  2. "Classification and staging of malignant tumors in the female pelvis", Acta Obstet Gynecol Scand, 50, pp.1~7 (1979)
  3. Scully RE, "Histologic typing of ovarian tumors", Arch Pathol Lab Med, 111, pp.794~795 (1987)
  4. Sherman ME, "Survival among women with borderline ovarian tumors and ovarian carcinoma: A population-based analysis", Cancer, 100, pp.1045~1052 (2004)
  5. Sherman ME, "Current challenges and opportunities for research on borderline ovarian tumors", Hum Pathol, 35, pp.961~970 (2004)
  6. Gershenson DM, "Clinical management potential tumours of low malignancy", Best Pract Res Clin Obstet Gynaecol, 16, pp.513~527 (2002)
  7. Kaern J, "DNA ploidy; the most important prognostic factor in patients with borderline tumors of the ovary", Int J Gynecol Cancer, 3, pp.349~358 (1993)
  8. Prat J, "Serous borderline tumors of the ovary: A long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion", Am J Surg Pathol, 26, pp.1111~1128 (2002)
  9. Eichhorn JH, "Ovarian serous borderline tumors with micropapillary and cribriform patterns: A study of 40 cases and comparison with 44 cases without these patterns", Am J Surg Pathol, 23, pp.397~409 (1999)
  10. Silverberg SG, "Borderline ovarian tumors: Key points and workshop summary", Hum Pathol, 35, pp.910~917 (2004)
  11. Seidman JD, "Ovarian serous borderline tumors: A critical review of the literature with emphasis on prognostic indicators", Hum Pathol, 31, pp.539~557 (2000)
  12. Morice P, "Prognostic factors for patients with advanced stage serous borderline tumours of the ovary", Ann Oncol, 14, pp.592~598 (2003)
  13. Kurman RJ, "Serous borderline tumours of the ovary", Histopathology, 47, pp.310~315 (2005)
  14. McKenney JK, "Lymph node involvement in ovarian serous tumors of low malignant potential (borderline tumors): Pathology, prognosis, and proposed classification", Am J Surg Pathol, 30, pp.614~624 (2006)
  15. Camatte S, "Impact of surgical staging in patients with macroscopic "stage Ⅰ" ovarian borderline tumours: Analysis of a continuous series of 101 cases", Eur J Cancer, 40, pp.1842~1849 (2004)
  16. Desfeux P, "Impact of surgical approach on the management of macroscopic early ovarian borderline tumors", Gynecol Oncol, 98, pp.390~395 (2005)
  17. 이정헌, "경계성 난소종양의 임상적 고찰", Korean Journal of Obstetrics and Gynecology, 46(1), pp.22~27 (2003), 대한산부인과학회
  18. 이상학, "경계성 난소종양의 임상적 고찰", Korean Journal of Obstetrics and Gynecology, 44(11), pp.1993~1999 (2001), 대한산부인과학회
  19. Menzin AW, "Contemporary surgical management of borderline ovarian tumors: A survey of the Society of Gynecologic Oncologists", Gynecol Oncol, 78, pp.7~9 (2000)
  20. Fauvet R, "Laparoscopic management of borderline ovarian tumors: Results of a French multicenter study", Ann Oncol, 16, pp.403~410 (2005)
  21. Fauvet R, "Restaging surgery for women with borderline ovarian tumors: Results of a French multicenter study", Cancer, 100, pp.1145~1151 (2004)
  22. Zanetta G, "Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: A prospective study", J Clin Oncol, 19, pp.2658~2664 (2001)
  23. Yazigi R, "Primary staging in ovarian tumors of low malignant potential", Gynecol Oncol, 31, pp.402~408 (1988)
  24. Snider DD, "Evaluation of surgical staging in stage Ⅰ low malignant potential ovarian tumors", Gynecol Oncol, 40, pp.129~132 (1991)
  25. Piura B, "Epithelial ovarian tumors of borderline malignancy: a study of 50 cases", Int J Gynecol Cancer, 2, pp.189~197 (1992)
  26. Leake JF, "Long-term follow-up of serous ovarian tumors of low malignant potential", Gynecol Oncol, 47, pp.150~158 (1992)
  27. Silva EG, "The recurrence and the overall survival rates of ovarian serous borderline neoplasms with noninvasive implants is time dependent", Am J Surg Pathol, 30, pp.1367~1371 (2006)
  28. Silva EG, "Tumor recurrence in stage Ⅰ ovarian serous neoplasms of low malignant potential", Int J Gynecol Pathol, 17, pp.1~6 (1998)
  29. Casey AC, "Epithelial ovarian tumors of borderline malignancy: long-term follow-up", Gynecol Oncol, 50, pp.316~322 (1993)
  30. Barnhill D, "Epithelial ovarian carcinoma of low malignant potential", Obstet Gynecol, 65, pp.53~59 (1985)
  31. Bostwick DG, "Ovarian epithelial tumors of borderline malignancy. A clinical and pathologic study of 109 cases", Cancer, 58, pp.2052~2065 (1986)
  32. Tamakoshi K, "Clinical behavior of borderline ovarian tumors: a study of 150 cases", J Surg Oncol, 64, pp.147~152 (1997)
  33. Vergote I, "Prognostic importance of degree of differentiation and cyst rupture in stage Ⅰ invasive epithelial ovarian carcinoma", Lancet, 357, pp.176~182 (2001)
  34. Vergote I, "Port-site metastases after open laparoscopy: A study in 173 patients with advanced ovarian carcinoma", Int J Gynecol Cancer, 15, pp.776~779 (2005)
  35. Camatte S, "Clinical outcome after laparoscopic pure management of borderline ovarian tumors: Results of a series of 34 patients", Ann Oncol, 15, pp.605~609 (2004)
  36. Vandenput I, "Peritoneal recurrences might be less common in advanced stage serous borderline ovarian tumors that were treated by laparotomy", Gynecol Oncol, 98, pp.523~ (2005)
  37. Tropé C, "Are borderline tumors of the ovary overtreated both surgically and systemically? A review of four prospective randomized trials including 253 patients with borderline tumors", Gynecol Oncol, 51, pp.236~243 (1993)
  38. Fort MG, "Evidence for the efficacy of adjuvant therapy in epithelial ovarian tumors of low malignant potential", Gynecol Oncol, 32, pp.269~272 (1989)
  39. Gershenson DM, "Serous ovarian tumors of low malignant potential with peritoneal implants", Cancer, 65, pp.578~585 (1990)
  40. Barnhill DR, "Preliminary analysis of the behavior of stage Ⅰ ovarian serous tumors of low malignant potential: a Gynecologic Oncology Group study", J Clin Oncol, 13, pp.2752~2756 (1995)
  41. Crispens MA, "Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential", Obstet Gynecol, 99, pp.3~10 (2002)
  42. Gotlieb WH, "Borderline tumors of the ovary: Fertility treatment, conservative management, and pregnancy outcome", Cancer, 82, pp.141~146 (1998)
  43. Morris RT, "Outcome and reproductive function after conservative surgery for borderline ovarian tumors", Obstet Gynecol, 95, pp.541~547 (2000)
  44. Fauvet R, "Fertility after conservative treatment for borderline ovarian tumors: A French multicenter study", Fertil Steril, 83, pp.284~290 (2005)
  45. Fortin A, "Impact of infertility drugs after treatment of borderline ovarian tumors: Results of a retrospective multicenter study", Fertil Steril, 87, pp.591~596 (2007)

관련 논문AI추천

이 간행물의 다른 논문 (11건)