자궁내막에 발생한 원발성 비성 NK/T세포 림프종 1예
Primary nasal type NK/T cell lymphoma of the endometrium: A case report
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여성생식기의 원발성 비호지킨성 림프종은 매우 드물며 자궁체부에 발생한 원발성 비호지킨성 림프종은 전체 림프절외 림프종 중 0.002%를 차지하고 있다.1 NK/T세포 림프종은 코, 후두, 상기도, 피부, 연부조직과 비강에 발생하며, 자궁을 침범하는 경우는 매우 드물어 원발성으로 여성생식기에 발생한 T세포/자연살해세포 (Natural Killer cell, NK cell) 림프종은 현재까지 Briese2,3 등이 보고한 3예 이외에는 보고된 바가 없다. 이에 저자들은 하복부통증과 혈성 질 분비물을 주소로 내원한 45세 여자 환자에서 자궁내막의 T세포/자연살해세포 림프종으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Non-Hodgkin lymphoma can involve the female genital tract usually as a manifestation of systemic disease, the vast majority of cases being B cell lineage. We report here one case of nasal type NK/T cell lymphoma arising in the uterus, of a 45-year-old Korean woman. The endometrium and myometrium showed diffuse infiltrative mass with hemorrhage and necrosis. Microscopic examination of the tumor revealed medium-sized atypical lymphoid cells. The tumor cells were positive for cytoplasmic CD3 and CD56, and were negative for vimentin, CD10, smooth muscle actin and desmin. Furthermore, In situ hybridization analysis for Epstein-Barr virus (EBV) RNA was positive. The histopathologic and immunohistochemical findings were consistent with extranodal nasal type NK/T cell lymphoma. We report this case to illustrate that NK/T cell lymphomas can involve, and rarely arise in, the gynecologic tract.
참고문헌 (7)
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