자궁근종 환자에서 측정한 혈중 bisphenol-A 농도
Serum bisphenol-A concentrations from uterine leiomyoma patients
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목적: 비스페놀-A (Bisphenol-A, BPA)가 자궁근종 환자에서 어느 정도 검출되며, BPA가 자궁근종의 성장에 어떤 영향을 미치는지 알아보고자 하였다. 연구 방법: 총 131명의 환자가 이번 연구에 참여하였다. 우선, 101명의 자궁근종 환자를 질식초음파로 측정한 자궁근종의 크기에 따라 mild군(n=38), moderate군(n=33), severe군(n=30)으로 나누고, 자궁근종이 없는 대조군 30명을 정하여 효소면역측정법(enzyme linked immunosorbent assay)으로 BPA 수치를 측정 비교하였다. 결과: 총 131명의 환자 중 BPA가 검출된 경우는 110건으로 검출률은 83.9%였다. 대조군은 86.7%에서 검출되었고, 자궁근종군은 전체 101명 중 83.1%에서 검출되었으며, 각 군별로는 mild군 중 71.1%에서, moderate군 중 84.9%에서, 그리고 severe군 중 96.7%에서 검출되었다. 각 군의 BPA의 평균농도는 평균±표준오차로 표시하여 대조군이 0.557±0.086 ng/mL, mild군이 0.273±0.052 ng/mL, moderate군이 0.336±0.063 ng/mL, 그리고 severe군이 0.636±0.075 ng/mL로 네 군 사이에 유의한 차이가 있었다(P=0.0003). 결론: 혈중 BPA의 검출율은 대조군에서 86.7%, 그리고 자궁근종군에서 83.1%였다. 이번 연구에서 대조군과 전체 자궁근종군의 혈중 BPA 농도에는 유의한 차이를 발견할 수 없었다. 향후 BPA가 자궁근종의 성장인자로 규명되기 위해서는 BPA에 폭로될 위험이 높은 사람들을 대상으로 한 보다 밀접하고 순차적인 연구가 필요하리라 생각된다.
Abstract
Objective: To investigate how many leiomyoma patients are exposed to bisphenol-A (BPA) and whether the serum concentration of BPA is related to leiomyoma growth. Methods: Total 131 patients were recruited for measuring BPA. Initially, leiomyoma patients were divided into three groups, mild (n=38), moderate (n=33), and severe (n=30) according to the size of the leiomyomas. The control (n=30) group was defined as having no leiomyomas. The identification and diameter measurements of leiomyomas was performed by transvaginal ultrasonography. Serum BPA concentrations were measured by enzyme linked immunosorbent assay. Results: BPA was detected in 83.9% out of 131 samples totally, and 83.1% out of 101 leiomyoma patients. In detail, the detection rates of serum BPA were 86.7% in control group, 71.1% in mild group, 84.9% in moderate group, and 96.7% in severe group. The mean BPA concentrations in the control group was 0.557±0.086 ng/mL and those in the leiomyoma groups were 0.273±0.052 ng/mL (mild), 0.336±0.063 ng/mL (moderate), and 0.636±0.075 ng/mL (severe) (P=0.0003). Values are mean±standard error. Conclusions: The detection rate of serum BPA in control and leiomyoma groups were 86.7% and 83.1% respectively. However, there was no statistical significance of serum BPA concentrations between control and leiomyoma groups. To verify the effect of BPA on the leiomyoma growth, close and sequential monitoring for the person who have exposure risk is recommended.
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