Vasomotor symptoms and the homeostatic model assessment of insulin-resistance in Korean postmenopausal women
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
The aim of this cross-sectional study was to evaluate the association between vasomotor symptoms (VMS) and insulin resistance, which can be postulated by the homeostatic model assessment (HOMA) index. This study involved 1,547 Korean postmenopausal women (age, 45 to 65 years) attending a routine health check-up at a single institution in Korea from January 2010 to December 2012. A menopause rating scale questionnaire was used to assess the severity of VMS. The mean age of participants was 55.22±4.8 years and 885 (57.2%) reported VMS in some degree. The mean HOMA index was 1.79±0.96, and the HOMA index increased with an increase in severity of VMS (none, mild, moderate and severe) in logistic regression analysis (β=0.068, t=2.665, P=0.008). Insulin resistance needs to be considered to understand the linkage between VMS and cardiometabolic disorders.
Abstract
The aim of this cross-sectional study was to evaluate the association between vasomotor symptoms (VMS) and insulin resistance, which can be postulated by the homeostatic model assessment (HOMA) index. This study involved 1,547 Korean postmenopausal women (age, 45 to 65 years) attending a routine health check-up at a single institution in Korea from January 2010 to December 2012. A menopause rating scale questionnaire was used to assess the severity of VMS. The mean age of participants was 55.22±4.8 years and 885 (57.2%) reported VMS in some degree. The mean HOMA index was 1.79±0.96, and the HOMA index increased with an increase in severity of VMS (none, mild, moderate and severe) in logistic regression analysis (β=0.068, t=2.665, P=0.008). Insulin resistance needs to be considered to understand the linkage between VMS and cardiometabolic disorders.
참고문헌 (20)
- Herber-Gast GC, "Risk factors for night sweats and hot flushes in midlife: results from a prospective cohort study", Menopause, 20, pp.953~959 (2013)
- Hunter M, "The south-east England longitudinal study of the climacteric and postmenopause", Maturitas, 14, pp.117~126 (1992)
- Ryu KJ, "Vasomotor symptoms and metabolic syndrome in Korean postmenopausal women", Menopause, 22, pp.1239~1245 (2015)
- Thurston RC, "Abdominal adiposity and hot flashes among midlife women", Menopause, 15, pp.429~434 (2008)
- Gast GC, "Menopausal complaints are associated with cardiovascular risk factors", Hypertension, 51, pp.1492~1498 (2008)
- Gast GC, "Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women", Maturitas, 66, pp.285~290 (2010)
- Chedraui P, "Menopausal symptoms and associated risk factors among postmenopausal women screened for the metabolic syndrome", Arch Gynecol Obstet, 275, pp.161~168 (2007)
- Lee SW, "Association between menopausal symptoms and metabolic syndrome in postmenopausal women", Arch Gynecol Obstet, 285, pp.541~548 (2012)
- Thurston RC, "Vasomotor symptoms and insulin resistance in the study of women’s health across the nation", J Clin Endocrinol Metab, 97, pp.3487~3494 (2012)
- Hauser GA, "Evaluation of climacteric symptoms(Menopause Rating Scale)", Zentralbl Gynakol, 116, pp.16~23 (1994)
- Matthews DR, "Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Hou ZM, "Effects of insulin resistance on myometrial growth", Int J Clin Exp Med, 8, pp.1552~1557 (2015)
- Clapauch R, "Endothelial function and insulin resistance in early postmenopausal women with cardiovascular risk factors: importance of ESR1 and NOS3 polymorphisms", PLoS One, 9, pp.e103444~ (2014)
- Lo JC, "The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife", Am J Med, 119(9Suppl 1), pp.S69~S78 (2006)
- Burger HG, "Hormonal changes in the menopause transition", Recent Prog Horm Res, 57, pp.257~275 (2002)
- Eckel RH, "Harrison’s principles of internal medicine", pp.1992~1997 (2012), McGraw-Hill Companies
- Freedman RR, "Pathophysiology and treatment of menopausal hot flashes", Semin Reprod Med, 23, pp.117~125 (2005)
- Cagnacci A, "Increased cortisol level : a possible link between climacteric symptoms and cardiovascular risk factors", Menopause, 18, pp.273~278 (2011)
- Salpeter SR, "Meta-analysis : effect of hormonereplacement therapy on components of the metabolic syndrome in postmenopausal women", Diabetes Obes Metab, 8, pp.538~554 (2006)
- Semenkovich CF, "Insulin resistance and atherosclerosis", J Clin Invest, 116, pp.1813~1822 (2006)