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Vasomotor Symptoms: More Than Temporary Menopausal Symptoms

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초록

Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.

Abstract

Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.

참고문헌 (47)

  1. Khang YH, "Trends in inequality in life expectancy at birth between 2004 and 2017 and projections for 2030 in Korea : multiyear cross-sectional differences by income from national health insurance data", BMJ Open, 9, pp.e030683~ (2019)
  2. Boulet MJ, "Climacteric and menopause in seven south-east Asian countries", Maturitas, 61, pp.34~53 (2008)
  3. Avis NE, "Duration of menopausal vasomotor symptoms over the menopause transition", JAMA Intern Med, 175, pp.531~539 (2015)
  4. Stuenkel CA, "Treatment of symptoms of the menopause : an endocrine society clinical practice guideline", J Clin Endocrinol Metab, 100, pp.3975~4011 (2015)
  5. The NAMS 2017 Hormone Therapy Position Statement Advisory Panel, "The 2017 hormone therapy position statement of The North American Menopause Society", Menopause, 24, pp.728~753 (2017)
  6. Prague JK, "Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes : a phase 2, randomised, doubleblind, placebo-controlled trial", Lancet, 389, pp.1809~1820 (2017)
  7. Lee SW, "Association between menopausal symptoms and metabolic syndrome in postmenopausal women", Arch Gynecol Obstet, 285, pp.541~548 (2012)
  8. Ryu KJ, "Vaso-motor symptoms and osteoporosis in Korean postmenopausal women", Maturitas, 87, pp.27~32 (2016)
  9. Ryu KJ, "Moderate to severe vasomotor symptoms are risk factors for non-alcoholic fatty liver disease in postmenopausal women", Maturitas, 117, pp.22~28 (2018)
  10. 권대휘, "Vasomotor symptoms and the homeostatic model assessment of insulin-resistance in Korean postmenopausal women", Obstetrics & Gynecology Science, 59(1), pp.45~49 (2016), 대한산부인과학회[DOI]
  11. Tuomikoski P, "Vasomotor symptoms and metabolic syndrome", Maturitas, 97, pp.61~65 (2017)
  12. Campagnoli C, "Climacteric symptoms according to body weight in women of different socio-economic groups", Maturitas, 3, pp.279~287 (1981)
  13. Gast GC, "Menopausal complaints are associated with cardiovascular risk factors", Hypertension, 51, pp.1492~1498 (2008)
  14. Ryu KJ, "Vasomotor symptoms and metabolic syndrome in Korean postmenopausal women", Menopause, 22, pp.1239~1245 (2015)
  15. Thurston RC, "Adipokines, adiposity, and vasomotor symptoms during the menopause transition : findings from the Study of Women's Health across the Nation", Fertil Steril, 100, pp.793~800 (2013)
  16. Anderson GS, "Calculated thermal conductivities and heat flux in man", Undersea Hyperb Med, 21, pp.431~441 (1994)
  17. Gold EB, "Longitudinal analysis of changes in weight and waist circumference in relation to incident vasomotor symptoms : the Study of Women's Health Across the Nation(SWAN)", Menopause, 24, pp.9~26 (2017)
  18. Saccomani S, "Does obesity increase the risk of hot flashes among midlife women? : a population-based study", Menopause, 24, pp.1065~1070 (2017)
  19. Luheshi GN, "Leptin actions on food intake and body temperature are mediated by IL-1", Proc Natl Acad Sci U S A, 96, pp.7047~7052 (1999)
  20. Expert Panel on Detection, Evaluation, "Executive summary of the third report of The National Cholesterol Education Program (NCEP)expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)", JAMA, 285, pp.2486~2497 (2001)
  21. Lim S, "Increasing prevalence of metabolic syndrome in Korea : the Korean National Health and Nutrition Examination Survey for 1998-2007", Diabetes Care, 34, pp.1323~1328 (2011)
  22. Jouyandeh Z, "Metabolic syndrome and menopause", J Diabetes Metab Disord, 12, pp.1~ (2013)
  23. Thurston RC, "Vasomotor symptoms and lipid profiles in women transitioning through menopause", Obstet Gynecol, 119, pp.753~761 (2012)
  24. Franco OH, "Vasomotor symptoms in women and cardiovascular risk markers : Systematic review and meta-analysis", Maturitas, 81, pp.353~361 (2015)
  25. Sahakyan KR, "Normal-weight central obesity : implications for total and cardiovascular mortality", Ann Intern Med, 163, pp.827~835 (2015)
  26. Vongpatanasin W, "Autonomic regulation of blood pressure in menopause", Semin Reprod Med, 27, pp.338~345 (2009)
  27. Freedman RR, "Pathophysiology and treatment of menopausal hot flashes", Semin Reprod Med, 23, pp.117~125 (2005)
  28. Gray KE, "Vasomotor symptom characteristics : are they risk factors for incident diabetes", Menopause, 25, pp.520~530 (2018)
  29. Thurston RC, "Vasomotor symptoms and insulin resistance in the study of women's health across the nation", J Clin Endocrinol Metab, 97, pp.3487~3494 (2012)
  30. Writing Group Members, "Heart disease and stroke statistics-2016update: a report from the American Heart Association", Circulation, 133, pp.e38~e39 (2016)
  31. Muka T, "Association of age at onset of menopause and time since onset of menopause with cardiovascular outcomes, intermediate vascular traits, and all-cause mortality : a systematic review and meta-analysis", JAMA Cardiol, 1, pp.767~776 (2016)
  32. Herber-Gast G, "Hot flushes and night sweats are associated with coronary heart disease risk in midlife : a longitudinal study", BJOG, 122, pp.1560~1567 (2015)
  33. Thurston RC, "Hot flashes and carotid intima media thickness among midlife women", Menopause, 18, pp.352~358 (2011)
  34. Muka T, "Association of vasomotor and other menopausal symptoms with risk of cardiovascular disease : a systematic review and meta-analysis", PLoS One, 11, pp.e0157417~ (2016)
  35. Thurston RC, "Trajectories of vasomotor symptoms and carotid intima media thickness in the study of Women's Health across the Nation", Stroke, 47, pp.12~17 (2016)
  36. Thurston RC, "History of hot flashes and aortic calcification among postmenopausal women", Menopause, 17, pp.256~261 (2010)
  37. Collins P, "Management of cardiovascular risk in the perimenopausal women : a consensus statement of European cardiologists and gynecologists", Climacteric, 10, pp.508~526 (2007)
  38. Sanyal AJ, "Endpoints and clinical trial design for nonalcoholic steatohepatitis", Hepatology, 54, pp.344~353 (2011)
  39. Gutierrez-Grobe Y, "Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens", Ann Hepatol, 9, pp.402~409 (2010)
  40. Cobbina E, "Non-alcoholic fatty liver disease(NAFLD)-pathogenesis, classification, and effect on drug metabolizing enzymes and transporters", Drug Metab Rev, 49, pp.197~211 (2017)
  41. Sigala B, "Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells", PLoS One, 8, pp.e72928~ (2013)
  42. Cummings SR, "Endogenous hormones and the risk of hip and vertebral fractures among older women", N Engl J Med, 339, pp.733~738 (1998)
  43. 민용기, "Update on Denosumab Treatment in Postmenopausal Women with Osteoporosis", Endocrinology and Metabolism, 30(1), pp.19~26 (2015), 대한내분비학회
  44. Gast GC, "Vasomotor symptoms are associated with a lower bone mineral density", Menopause, 16, pp.231~238 (2009)
  45. Ozkaya E, "Impact of hot flashes and night sweats on carotid intima-media thickness and bone mineral density among postmenopausal women", Int J Gynaecol Obstet, 113, pp.235~238 (2011)
  46. Huang A, "Hot flushes, bone mineral density, and fractures in older postmenopausal women", Obstet Gynecol, 109, pp.841~847 (2007)
  47. Levin VA, "Estrogen therapy for osteoporosis in the modern era", Osteoporos Int, 29, pp.1049~1055 (2018)

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