Recurrent pregnancy loss: can factor V Leiden mutations be a cause
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The role of Factor V Leiden (FVL) mutation in recurrent miscarriages has been disputed. It has been hypothesized thatFVL mutation in patients with recurrent miscarriages is treatable. In this study, we evaluated 78 pregnant womenfor FVL mutations, among whom 50 had a history of recurrent miscarriages. Only 1 (2%) of the woman was positivefor heterozygous FVL mutation. The incidence of FVL mutations in patients with recurrent pregnancy loss had anodds ratio of 1.72 (95% confidence interval, 0.0681–43.8257; P>0.05). However, the findings were not statisticallysignificant. Thus, we suggest that FVL mutation study may not be included in the battery of tests for recurrentmiscarriages in the Indian population.
Abstract
The role of Factor V Leiden (FVL) mutation in recurrent miscarriages has been disputed. It has been hypothesized thatFVL mutation in patients with recurrent miscarriages is treatable. In this study, we evaluated 78 pregnant womenfor FVL mutations, among whom 50 had a history of recurrent miscarriages. Only 1 (2%) of the woman was positivefor heterozygous FVL mutation. The incidence of FVL mutations in patients with recurrent pregnancy loss had anodds ratio of 1.72 (95% confidence interval, 0.0681–43.8257; P>0.05). However, the findings were not statisticallysignificant. Thus, we suggest that FVL mutation study may not be included in the battery of tests for recurrentmiscarriages in the Indian population.
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