How much have the perinatal outcomes of triplet pregnancies improved over the last two decades?
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ObjectiveThis study was conducted to demonstrate the temporal trends in perinatal outcomes of triplet pregnancies over thelast two decades. MethodsThe medical records of patients with triplet pregnancies at two Korean tertiary-care hospitals from 1992 to 2012 wereretrospectively reviewed in regard to maternal and neonatal outcomes. The study was divided into two periods foranalysis: period I (1992–2001) and period II (2003–2012). ResultsOver a 21-year period, 65 women with triplet pregnancies and 185 neonates were analyzed. Period II, whencompared with period I, was associated with improved maternal outcomes, characterized by a decreased incidenceof preeclampsia (31.8% vs. 2.3%, P=0.002) and anemia (68.2% vs. 30.2%, P=0.003) during pregnancy. Regardingneonatal aspects, the composite morbidity of period II was significantly decreased compared with that of period I,as assessed with a generalized estimating equation for logistic regression (26.2% vs. 8.1%, P=0.03). Multivariableanalysis revealed that the gestational age at delivery and the period were significantly associated with the compositeneonatal morbidity (P<0.001 and 0.007, respectively). ConclusionImproved neonatal morbidity was associated with a higher gestational age at delivery and with the more recentdecade.
Abstract
ObjectiveThis study was conducted to demonstrate the temporal trends in perinatal outcomes of triplet pregnancies over thelast two decades. MethodsThe medical records of patients with triplet pregnancies at two Korean tertiary-care hospitals from 1992 to 2012 wereretrospectively reviewed in regard to maternal and neonatal outcomes. The study was divided into two periods foranalysis: period I (1992–2001) and period II (2003–2012). ResultsOver a 21-year period, 65 women with triplet pregnancies and 185 neonates were analyzed. Period II, whencompared with period I, was associated with improved maternal outcomes, characterized by a decreased incidenceof preeclampsia (31.8% vs. 2.3%, P=0.002) and anemia (68.2% vs. 30.2%, P=0.003) during pregnancy. Regardingneonatal aspects, the composite morbidity of period II was significantly decreased compared with that of period I,as assessed with a generalized estimating equation for logistic regression (26.2% vs. 8.1%, P=0.03). Multivariableanalysis revealed that the gestational age at delivery and the period were significantly associated with the compositeneonatal morbidity (P<0.001 and 0.007, respectively). ConclusionImproved neonatal morbidity was associated with a higher gestational age at delivery and with the more recentdecade.
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