Prediction of preeclampsia in the first trimester of pregnancy using maternal characteristics, mean arterial pressure, and uterine artery Doppler data in a Brazilian population
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ObjectiveTo evaluate the performance of the preeclampsia (PE) screening algorithm of the Fetal Medicine Foundation (FMF)during the first trimester in a Brazilian population using maternal characteristics, mean arterial pressure (MAP), anduterine artery Doppler data. MethodsThis is a prospective cohort study that evaluated 701 pregnant women during the first trimester ultrasound screeningfor chromosomal abnormalities (11–13+6 weeks). All patients provided information regarding clinical and obstetrichistory, MAP, and mean uterine artery pulsatility index (mean PI). Patients were assigned to four groups based on thepresence of PE and gestational age at delivery: group 1 (control), patients without hypertensive disorders (n=571);group 2, PE and delivery before 34 weeks of gestation (n=7); group 3, PE and delivery before 37 weeks of gestation,including patients from group 2 and patients that presented PE with delivery between 34 and 37 weeks (n=17); andgroup 4, PE and delivery before 42 weeks of gestation, including patients from both groups 2 and 3 and patients thatpresented PE with delivery between 37 and 42 weeks of gestation (n=34). ResultsAfter the exclusion of 96 patients, we evaluated the data of 605 patients. By combining maternal characteristics, MAP,and the mean uterine artery PI for the detection of PE, we found a sensitivity of 71.4% in group 2, 50% in group 3,and 41.2% in group 4 (false positive rate=10%). ConclusionUsing maternal characteristics, MAP, and uterine artery Doppler data, we were able to identify a significantproportion of patients who developed preterm PE.
Abstract
ObjectiveTo evaluate the performance of the preeclampsia (PE) screening algorithm of the Fetal Medicine Foundation (FMF)during the first trimester in a Brazilian population using maternal characteristics, mean arterial pressure (MAP), anduterine artery Doppler data. MethodsThis is a prospective cohort study that evaluated 701 pregnant women during the first trimester ultrasound screeningfor chromosomal abnormalities (11–13+6 weeks). All patients provided information regarding clinical and obstetrichistory, MAP, and mean uterine artery pulsatility index (mean PI). Patients were assigned to four groups based on thepresence of PE and gestational age at delivery: group 1 (control), patients without hypertensive disorders (n=571);group 2, PE and delivery before 34 weeks of gestation (n=7); group 3, PE and delivery before 37 weeks of gestation,including patients from group 2 and patients that presented PE with delivery between 34 and 37 weeks (n=17); andgroup 4, PE and delivery before 42 weeks of gestation, including patients from both groups 2 and 3 and patients thatpresented PE with delivery between 37 and 42 weeks of gestation (n=34). ResultsAfter the exclusion of 96 patients, we evaluated the data of 605 patients. By combining maternal characteristics, MAP,and the mean uterine artery PI for the detection of PE, we found a sensitivity of 71.4% in group 2, 50% in group 3,and 41.2% in group 4 (false positive rate=10%). ConclusionUsing maternal characteristics, MAP, and uterine artery Doppler data, we were able to identify a significantproportion of patients who developed preterm PE.
참고문헌 (14)
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