A study to compare maternal and perinatal outcome in early vs. late onset preeclampsia
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ObjectiveThe risk factors, clinical trends, and maternal and fetal health of early- and late-onset preeclampsia have not beenadequately studied. We examined the effects of early- and late-onset preeclampsia on maternal and perinataloutcomes as well as the known risk factors of preeclampsia. MethodsOne hundred and fifty women with preeclampsia were consecutively enrolled in each group. Those who developedpreeclampsia before 34 weeks of gestation were identified as having early-onset preeclampsia, while those whodeveloped at 34 weeks or later were identified as having late-onset preeclampsia. Maternal and perinatal outcomeswere compared between groups. ResultsCompared with the late-onset group, the early-onset group had higher rates of abruptio placentae (16% vs. 7.3%;P=0.019), but there was no intergroup difference in the composite maternal outcomes. A significantly higher numberof women with early-onset preeclampsia developed severe features during the disease course, and most requiredtreatment with antihypertensive drugs. Late-onset preeclampsia was more prevalent among primigravid mothers. Babies born to mothers with early-onset preeclampsia had a significantly higher rate of adverse outcomes. ConclusionThese study findings indicate that women with early-onset preeclampsia had more adverse outcome than those withlate-onset preeclampsia, but the difference was not statistically significant. There were more babies with adverseperinatal outcomes in the early-than late-onset group.
Abstract
ObjectiveThe risk factors, clinical trends, and maternal and fetal health of early- and late-onset preeclampsia have not beenadequately studied. We examined the effects of early- and late-onset preeclampsia on maternal and perinataloutcomes as well as the known risk factors of preeclampsia. MethodsOne hundred and fifty women with preeclampsia were consecutively enrolled in each group. Those who developedpreeclampsia before 34 weeks of gestation were identified as having early-onset preeclampsia, while those whodeveloped at 34 weeks or later were identified as having late-onset preeclampsia. Maternal and perinatal outcomeswere compared between groups. ResultsCompared with the late-onset group, the early-onset group had higher rates of abruptio placentae (16% vs. 7.3%;P=0.019), but there was no intergroup difference in the composite maternal outcomes. A significantly higher numberof women with early-onset preeclampsia developed severe features during the disease course, and most requiredtreatment with antihypertensive drugs. Late-onset preeclampsia was more prevalent among primigravid mothers. Babies born to mothers with early-onset preeclampsia had a significantly higher rate of adverse outcomes. ConclusionThese study findings indicate that women with early-onset preeclampsia had more adverse outcome than those withlate-onset preeclampsia, but the difference was not statistically significant. There were more babies with adverseperinatal outcomes in the early-than late-onset group.
참고문헌 (21)
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