Role of microRNAs as biomarkers of cervical carcinogenesis: a systematic review
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We performed a systematic review to identify the role of microRNAs (miRNAs) as biomarkers in the progressionof cervical precancerous lesions. A comprehensive search of the Cochrane Controlled Register of Trials, PubMed,ScienceDirect, and Embase databases was performed for articles published between January 2010 and June 2020. Thefollowing Medical Subject Headings (MeSH) terms were searched: “microRNA” and “cervical” and “lesion.” All studydesigns that aimed to evaluate the correlation of miRNA expression with different precancerous cervical staging and/or cervical cancer were included, except for case reports and case series. Approximately 82 individual miRNAs werefound to be significant in differentiating the stages of cervical carcinogenesis. Among the miRNAs, miR-21 is the mostprevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stagesin both cell and serum samples. miR-205 has been shown to have a higher specificity than human papilloma virustesting in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in lowgradesquamous intraepithelial lesions, HSILs, and cervical cancer. We found significant dysregulated miRNAs incervical carcinogenesis with their dynamic expression changes and ability to detect viral persistency, risk prediction oflow-grade lesions (cervical intraepithelial neoplasia [CIN] 2) to high-grade lesions (CIN 3), and progression of CIN 3 tocancer. Their ability to discriminate HSILs from non-dysplastic lesions has potential implications in early diagnosis andreducing overtreatment of otherwise regressive early preinvasive lesions.
Abstract
We performed a systematic review to identify the role of microRNAs (miRNAs) as biomarkers in the progressionof cervical precancerous lesions. A comprehensive search of the Cochrane Controlled Register of Trials, PubMed,ScienceDirect, and Embase databases was performed for articles published between January 2010 and June 2020. Thefollowing Medical Subject Headings (MeSH) terms were searched: “microRNA” and “cervical” and “lesion.” All studydesigns that aimed to evaluate the correlation of miRNA expression with different precancerous cervical staging and/or cervical cancer were included, except for case reports and case series. Approximately 82 individual miRNAs werefound to be significant in differentiating the stages of cervical carcinogenesis. Among the miRNAs, miR-21 is the mostprevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stagesin both cell and serum samples. miR-205 has been shown to have a higher specificity than human papilloma virustesting in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in lowgradesquamous intraepithelial lesions, HSILs, and cervical cancer. We found significant dysregulated miRNAs incervical carcinogenesis with their dynamic expression changes and ability to detect viral persistency, risk prediction oflow-grade lesions (cervical intraepithelial neoplasia [CIN] 2) to high-grade lesions (CIN 3), and progression of CIN 3 tocancer. Their ability to discriminate HSILs from non-dysplastic lesions has potential implications in early diagnosis andreducing overtreatment of otherwise regressive early preinvasive lesions.
참고문헌 (59)
- de Martel C, "Worldwide burden of cancer attributable to HPV by site, country and HPV type", Int J Cancer, 141, pp.664~670 (2017)
- Bray F, "Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA Cancer J Clin, 68, pp.394~424 (2018)
- Demarco M, "Risks of CIN 2+, CIN 3+, and cancer by cytology and human papillomavirus status: the foundation of risk-based cervical screening guidelines", J Low Genit Tract Dis, 21, pp.261~267 (2017)
- Lowy DR, "Papillomaviruses and cervical cancer:pathogenesis and vaccine development", J Natl Cancer Inst Monogr, (23), pp.27~30 (1998)
- Schiffman M, "Human papillomavirus and cervical cancer", Lancet, 370, pp.890~907 (2007)
- Frega A, "Sensitivity and specificity values of high-risk HPV DNA, p16", ki-67 and HPV mRNA in young women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL), 2019, pp.23, 10672~10677
- Persson M, "Triage of HR-HPV positive women with minor cytological abnormalities: a comparison of mRNA testing, HPV DNA testing, and repeat cytology using a 4-year follow-up of a population-based study", PLoS One, 9, pp.e90023~ (2014)
- Ambros V, "A uniform system for microRNA annotation", RNA, 9, pp.277~279 (2003)
- Siomi H, "Posttranscriptional regulation of microRNA biogenesis in animals", Mol Cell, 38, pp.323~332 (2010)
- Farazi TA, "MiRNAs and cancer", Adv Exp Med Biol (2012)[DOI]
- Visone R, "MiRNAs and cancer", Am J Pathol, 174, pp.1131~1138 (2009)
- Iorio MV, "MicroRNA signatures in human ovarian cancer", Cancer Res, 67, pp.8699~8707 (2007)
- Thomson JM, "Extensive post-transcriptional regulation of microRNAs and its implications for cancer", Genes Dev, 20, pp.2202~2207 (2006)
- Wells GA, "The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses", OHRI (2000)
- Moola S, "Chapter 7: systematic reviews of etiology and risk", JBI (2020)
- Babion I, "Triage of high-risk HPVpositive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study", Clin Epigenetics, 10, pp.76~ (2018)
- Babion I, "Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease", Epigenetics, 14, pp.558~567 (2019)
- Wilting SM, "Methylation-mediated silencing and tumour suppressive function of hsa-miR-124in cervical cancer", Mol Cancer, 9, pp.167~ (2010)
- Wilting SM, "Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis", Oncogene, 32, pp.106~116 (2013)
- Ribeiro J, "miR-34a and miR-125b expression in HPV infection and cervical cancer development", Biomed Res Int, 2015, pp.304584~ (2015)
- Pereira PM, "MicroRNA expression variability in human cervical tissues", PLoS One, 5, pp.e11780~ (2010)
- Malta M, "Let-7c is a candidate biomarker for cervical intraepithelial lesions : a pilot study", Mol Diagn Ther, 19, pp.191~196 (2015)
- Sharma S, "Novel MicroRNA signatures in HPV-mediated cervical carcinogenesis in Indian women", Tumour Biol, 37, pp.4585~4595 (2016)
- Shishodia G, "Alterations in microRNAs miR-21and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis", Mol Cancer, 14, pp.116~ (2015)
- Jiménez-Wences H, "Methylation and expression of miRNAs in precancerous lesions and cervical cancer with HPV16 infection", Oncol Rep, 35, pp.2297~2305 (2016)
- Campos-Viguri GE, "miR-23b as a potential tumor suppressor and its regulation by DNA methylation in cervical cancer", Infect Agent Cancer, 10, pp.42~ (2015)
- Bumrungthai S, "Patarapadungkit N, et al. Up-regulation of miR-21 is associated with cervicitis and human papillomavirus infection in cervical tissues", PLoS One, 10, pp.e0127109~ (2015)
- Kawai S, "Identification of miRNAs in cervical mucus as a novel diagnostic marker for cervical neoplasia", Sci Rep, 8, pp.7070~ (2018)
- Ivanov MK, "Detection of highgrade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier", Oncol Rep, 39, pp.1099~1111 (2018)
- Lukic A, "MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia", Eur Rev Med Pharmacol Sci, 22, pp.4448~4457 (2018)
- Gocze K, "MicroRNA expressions in HPV-induced cervical dysplasia and cancer", Anticancer Res, 35, pp.523~530 (2015)
- Sommerova L, "The role of miR-409-3p in regulation of HPV16", 18-E6 mRNA in human cervical highgrade squamous intraepithelial lesions, 2019, pp.163, 185~192
- Xie H, "Evaluation of microRNA-205 expression as a potential triage marker for patients with low-grade squamous intraepithelial lesions", Oncol Lett, 13, pp.3586~3598 (2017)
- Piersma SJ, "Immunosuppressive tumor microenvironment in cervical cancer patients", Cancer Microenviron, 4, pp.361~375 (2011)
- Okoye JO, "Comparable expression of miR-let-7b, miR-21, miR-182, miR-145, and p53 in serum and cervical cells: diagnostic implications for early detection of cervical lesions", Int J Health Sci(Qassim), 13, pp.29~38 (2019)
- Pfeffer SR, "the role of miR-21 in cancer", Drug Dev Res, 76, pp.270~277 (2015)
- Zhang L, "MicroRNA-34 family : a potential tumor suppressor and therapeutic candidate in cancer", J Exp Clin Cancer Res, 38, pp.53~ (2019)
- Lu J, "Hypomethylation causes MIR21 overexpression in tumors", Mol Ther Oncolytics, 18, pp.47~57 (2020)
- Liu SS, "Oncogenic microRNA signature for early diagnosis of cervical intraepithelial neoplasia and cancer", Mol Oncol, 12, pp.2009~2022 (2018)
- Ye J, "MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL", CIN1diagnosis after colposcopy-guided biopsy, 2019, pp.19, 112~
- Zhang J, "Interferon-β induced microRNA-129-5p down-regulates HPV-18 E6 and E7 viral gene expression by targeting SP1in cervical cancer cells", PLoS One, 8, pp.e81366~ (2013)
- Wang J, "MiR-1266 promotes cell proliferation, migration and invasion in cervical cancer by targeting DAB2IP", Biochim Biophys Acta Mol Basis Dis, 1864, pp.3623~3630 (2018)
- Wang H, "Plasma expression of miRNA-21, - 214, -34a, and -200a in patients with persistent HPV infection and cervical lesions", BMC Cancer, 19, pp.986~ (2019)
- Zhou LL, "MicroRNA-466 with tumor markers for cervical cancer screening", Oncotarget, 8, pp.70821~70827 (2017)
- Yang X, "Clinical value of combined detection of miR-1202 and miR-195 in early diagnosis of cervical cancer", Oncol Lett, 17, pp.3387~3391 (2019)
- Wen F, "Increased expression of miR-15b is associated with clinicopathological features and poor prognosis in cervical carcinoma", Arch Gynecol Obstet, 295, pp.743~749 (2017)
- Wang F, "MiR-155-5p inhibits PDK1 and promotes autophagy via the mTOR pathway in cervical cancer", Int J Biochem Cell Biol, 99, pp.91~99 (2018)
- Wang X, "microRNAs are biomarkers of oncogenic human papillomavirus infections", Proc Natl Acad Sci U S A, 111, pp.4262~4267 (2014)
- Wang Z, "Folate inhibits miR-27a-3p expression during cervical carcinoma progression and oncogenic activity in human cervical cancer cells", Biomed Pharmacother, 122, pp.109654~ (2020)
- Wang L, "Expression of MiR200a, miR93, metastasis-related gene RECK and MMP2", MMP9in human cervical carcinoma--relationship with prognosis, 2013, pp.14, 2113~2118
- Zeng K, "Dysregulated microRNAs involved in the progression of cervical neoplasm", Arch Gynecol Obstet, 292, pp.905~913 (2015)
- Zhang J, "miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells", Biochem Biophys Res Commun, 440, pp.582~588 (2013)
- Zhu Y, "MiR-21-5p, miR-34a, and human telomerase RNA component as surrogate markers for cervical cancer progression", Pathol Res Pract, 214, pp.374~379 (2018)
- Sheedy FJ, "Turning 21 : Induction of miR-21 as a key switch in the inflammatory response", Front Immunol, 6, pp.19~ (2015)
- Li B, "Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection", Int J Gynecol Cancer, 20, pp.597~604 (2010)
- Chen X, "Characterization of microRNAs in serum : a novel class of biomarkers for diagnosis of cancer and other diseases", Cell Res, 18, pp.997~1006 (2008)
- Dickson EL, "Cervical cytology and multiple type HPV infection : a study of 8182 women ages 31-65", Gynecol Oncol, 133, pp.405~408 (2014)
- El-Hefnawy T, "Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics", Clin Chem, 50, pp.564~573 (2004)
- Zummeren MV, "HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions", Mod Pathol, 31, pp.1842~1850 (2018)