Correlation between the expression of matrix metalloproteinase 9 and the expression of tissue inhibitor of metalloproteinase-1 of uterosacral ligament in uterine prolapse
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: This study aimed to analyze the correlation between the immunoexpression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TiMP1) in the uterosacral ligaments in patients with uterine prolapse. Methods: This analytic-correlative cross-sectional study included 32 patients who were admitted at the Hasan Sadikin General Hospital from July to December 2013. Sixteen of the patients had uterine prolapse, while the rest did not. The patients underwent total hysterectomy, radical hysterectomy, or staging laparotomy. MMP-9 and TiMP1 expression in the uterosacral ligaments was measured via immunohistochemical staining. The median expression per field of view was calculated using a histoscore. Results: MMP-9 expression in patients with uterine prolapse was found to be higher than that in the control group. Meanwhile, TiMP1 expression showed no significant difference between the groups. Spearman's analysis showed a moderate correlation between the expression of MMP-9 and uterine prolapse incidence (P=0.02), with a correlation coefficient of 0.574. Conclusion: There is a moderate correlation between MMP-9 expression and the incidence of uterine prolapse. It can be considered one of the primary etiologies of uterine prolapse.
Abstract
Objective: This study aimed to analyze the correlation between the immunoexpression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TiMP1) in the uterosacral ligaments in patients with uterine prolapse. Methods: This analytic-correlative cross-sectional study included 32 patients who were admitted at the Hasan Sadikin General Hospital from July to December 2013. Sixteen of the patients had uterine prolapse, while the rest did not. The patients underwent total hysterectomy, radical hysterectomy, or staging laparotomy. MMP-9 and TiMP1 expression in the uterosacral ligaments was measured via immunohistochemical staining. The median expression per field of view was calculated using a histoscore. Results: MMP-9 expression in patients with uterine prolapse was found to be higher than that in the control group. Meanwhile, TiMP1 expression showed no significant difference between the groups. Spearman's analysis showed a moderate correlation between the expression of MMP-9 and uterine prolapse incidence (P=0.02), with a correlation coefficient of 0.574. Conclusion: There is a moderate correlation between MMP-9 expression and the incidence of uterine prolapse. It can be considered one of the primary etiologies of uterine prolapse.
참고문헌 (14)
- 전명재, "Surgical decision making for symptomatic pelvic organ prolapse: evidence-based approach", Obstetrics & Gynecology Science, 62(5), pp.307~312 (2019), 대한산부인과학회[DOI]
- MacLennan AH, "The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery", BJOG, 107, pp.1460~1470 (2000)
- Awwad J, "Prevalence, risk factors, and predictors of pelvic organ prolapse : a community-based study", Menopause, 19, pp.1235~1241 (2012)
- Mant J, "Epidemiology of genital prolapse : observations from the oxford family planning association study", Br J Obstet Gynaecol, 104, pp.579~585 (1997)
- Bump RC, "Epidemiology and natural history of pelvic floor dysfunction", Obstet Gynecol Clin North Am, 25, pp.723~746 (1998)
- Sabbagh MD, "Abstract : gender reassignment surgery using the pedicle transverse colon flap for vaginal reconstruction : a clinical outcome and sexual function evaluation study", Plast Reconstr Surg-Glob Open, 6(8 Suppl), pp.138~139 (2018)
- Bureau M, "Pelvic organ prolapse : a primer for urologists", Can Urol Assoc J, 11(6Suppl2), pp.S125~S130 (2017)
- Ewies AA, "Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse : a computerized immunohistomorphometric analysis", Hum Reprod, 18, pp.2189~2195 (2003)
- Schaffer JI, "Etiology of pelvic organ prolapse", Clin Obstet Gynecol, 48, pp.639~647 (2005)
- 김보혜, "Correlation between obesity and pelvic organ prolapse in Korean women", Obstetrics & Gynecology Science, 63(6), pp.719~725 (2020), 대한산부인과학회[DOI]
- Strinic T, "Increased expression of matrix metalloproteinase-1 in uterosacral ligament tissue from women with pelvic organ prolapse", Acta Obstet Gynecol Scand, 89, pp.832~834 (2010)
- Moalli PA, "Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis", Am J Obstet Gynecol, 190, pp.620~627 (2004)
- Wang X, "Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse", Mol Med Rep, 10, pp.2004~2008 (2014)
- Chen BH, "Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse", Int Urogynecol J Pelvic Floor Dysfunct, 13, pp.80~87 (2002)