본문 바로가기
KERD
논문KCI 등재

Current Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

Although the prevalence of chronic hepatitis B has decreased considerably in recent years due to widespread use of the hepatitis B virus (HBV) vaccine, its prevalence still remains high in adults, and this can place a significant burden on health care in areas with endemic HBV. Since the introduction of nucleos(t)ide analogues (NUCs), there has been marked improvement in the care of patients with chronic hepatitis B, resulting in increased survival. However, the emergence of drug resistance in patients treated with NUCs is a major concern. The number of multi-drug resistant patients is increasing, and many patients may not respond to the currently available drugs. In this review, we describe the current status of NUC therapy for antiviral-naïve and -resistant patients.

Abstract

Although the prevalence of chronic hepatitis B has decreased considerably in recent years due to widespread use of the hepatitis B virus (HBV) vaccine, its prevalence still remains high in adults, and this can place a significant burden on health care in areas with endemic HBV. Since the introduction of nucleos(t)ide analogues (NUCs), there has been marked improvement in the care of patients with chronic hepatitis B, resulting in increased survival. However, the emergence of drug resistance in patients treated with NUCs is a major concern. The number of multi-drug resistant patients is increasing, and many patients may not respond to the currently available drugs. In this review, we describe the current status of NUC therapy for antiviral-naïve and -resistant patients.

참고문헌 (80)

  1. 김석배, "건강검진 수진자를 대상으로 한 충남 서북부 지역의 바이러스 간염 표지자 양성률 및 간수치 이상에 관한 연구", 대한소화기학회지, 53(6), pp.355~360 (2009), 대한소화기학회
  2. European Association for the Study of the Liver, "EASL Clinical Practice Guidelines: management of chronic hepatitis B", J Hepatol, 50, pp.227~242 (2009)
  3. Lok AS, "Chronic hepatitis B: update 2009", Hepatology, 50, pp.661~662 (2009)
  4. DiBisceglie A, "Telbivudine GLOBE trial: maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside treated hepatitis B patients", Hepatology, 44(Suppl 1), pp.230A~ (2006)
  5. Chen CJ, "Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level", JAMA, 295, pp.65~73 (2006)
  6. Iloeje UH, "Predicting cirrhosis risk based on the level of circulating hepatitis B viral load", Gastroenterology, 130, pp.678~686 (2006)
  7. Zoulim F, "Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection", Antiviral Res, 64, pp.1~15 (2004)
  8. Dienstag JL, "A preliminary trial of lamivudine for chronic hepatitis B infection", N Engl J Med, 333, pp.1657~1661 (1995)
  9. Dienstag JL, "Lamivudine as initial treatment for chronic hepatitis B in the United States", N Engl J Med, 341, pp.1256~1263 (1999)
  10. Lai CL, "A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group", N Engl J Med, 339, pp.61~68 (1998)
  11. Schalm SW, "Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial", Gut, 46, pp.562~568 (2000)
  12. Chang TT, "Four years of lamivudine treatment in Chinese patients with chronic hepatitis B", J Gastroenterol Hepatol, 19, pp.1276~1282 (2004)
  13. Yao GB, "A 7-year study of lamivudine therapy for hepatitis B virus e antigen-positive chronic hepatitis B patients in China", J Dig Dis, 10, pp.131~137 (2009)
  14. Hadziyannis SJ, "Efficacy of long-term lamivudine monotherapy in patients with hepatitis B e antigen-negative chronic hepatitis B", Hepatology, 32(4 Pt 1), pp.847~851 (2000)
  15. Lok AS, "Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy", Hepatology, 32, pp.1145~1153 (2000)
  16. Fung SK, "Sustained response after a 2-year course of lamivudine treatment of hepatitis B e antigen-negative chronic hepatitis B", J Viral Hepat, 11, pp.432~438 (2004)
  17. Heon Ju Lee, "Prevention by Lamivudine of Hepatocellular Carcinoma in Patients Infected with Hepatitis B Virus", Gut and Liver, 1(2), pp.151~158 (2007), 거트앤리버 발행위원회
  18. Liaw YF, "Lamivudine for patients with chronic hepatitis B and advanced liver disease", N Engl J Med, 351, pp.1521~1531 (2004)
  19. Nikolaidis N, "Effect of lamivudine treatment in patients with decompensated cirrhosis due to anti-HBe positive", HBeAg-negative chronic hepatitis B, 2005, pp.19, 321~326
  20. Dienstag JL, "Durability of serologic response after lamivudine treatment of chronic hepatitis B", Hepatology, 37, pp.748~755 (2003)
  21. Lee KM, "Effect of virological response on post-treatment durability of lamivudine-induced HBeAg seroconversion", J Viral Hepat, 9, pp.208~212 (2002)
  22. 정영화, "Hepatitis B e antigen seroconversion after lamivudine therapy is not durable in patients with chronic hepatitis B in Korea", HEPATOLOGY, 32(4 Pt 1), pp.803~806 (2000), JOHN WILEY & SONS INC
  23. Cha CK, "Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B", J Med Virol, 81, pp.417~424 (2009)
  24. Lok AS, "Long-term safety of lamivudine treatment in patients with chronic hepatitis B", Gastroenterology, 125, pp.1714~1722 (2003)
  25. Yuen MF, "Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy", Hepatology, 34(4 Pt 1), pp.785~791 (2011)
  26. Marcellin P, "Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B", N Engl J Med, 348, pp.808~816 (2003)
  27. Marcellin P, "Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B", Hepatology, 48, pp.750~758 (2008)
  28. Hadziyannis SJ, "Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B", N Engl J Med, 352, pp.2673~2681 (2005)
  29. Hadziyannis SJ, "Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B", N Engl J Med, 348, pp.800~807 (2003)
  30. Hadziyannis SJ, "Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years", Gastroenterology, 131, pp.1743~1751 (2006)
  31. Lim SG, "Clinical trial: effects of adefovir dipivoxil therapy in Asian and Caucasian patients with chronic hepatitis B", Aliment Pharmacol Ther, 26, pp.1419~1428 (2007)
  32. Angus P, "Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase", Gastroenterology, 125, pp.292~297 (2003)
  33. Villeneuve JP, "Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient", J Hepatol, 39, pp.1085~1089 (2003)
  34. Westland CE, "Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B", Hepatology, 38, pp.96~103 (2003)
  35. Fung SK, "Virologic response and resistance to adefovir in patients with chronic hepatitis B", J Hepatol, 44, pp.289~290 (2006)
  36. Lee YS, "Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy", HEPATOLOGY, 43(6), pp.1385~1391, JOHN WILEY & SONS INC
  37. Lee JM, "Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B", Antivir Ther, 15, pp.235~241 (2010)
  38. Chang TT, "A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B", N Engl J Med, 354, pp.1001~1010 (2006)
  39. Leung N, "Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: a randomized international study of entecavir versus adefovir", Hepatology, 49, pp.72~79 (2009)
  40. Lai CL, "Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B", N Engl J Med, 354, pp.1011~1020 (2006)
  41. Shim JH, "Efficacy of entecavir in treatment-naïve patients with hepatitis B virus-related decompensated cirrhosis", J Hepatol, 52, pp.176~182 (2010)
  42. 한광협, "Entecavir therapy for up to 96 weeks in patients with HBeAg-Positive chronic hepatitis B", GASTROENTEROLOGY, 133, pp.1437~1444, W B SAUNDERS CO-ELSEVIER INC
  43. Shouval D, "Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: the case for continuous antiviral therapy", J Hepatol, 50, pp.289~295 (2009)
  44. Tenney DJ, "Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy", Hepatology, 49, pp.1503~1514 (2009)
  45. Fournier C, "Antiviral therapy of chronic hepatitis B: prevention of drug resistance", Clin Liver Dis, 11, pp.869~892 (2007)
  46. 김동준, "Telbivudine versus lamivudine in patients with chronic hepatitis B", NEW ENGLAND JOURNAL OF MEDICINE, 357(25), pp.2576~2588, MASSACHUSETTS MEDICAL SOC
  47. 황성규, "2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B", GASTROENTEROLOGY, 136, pp.486~495, W B SAUNDERS CO-ELSEVIER INC
  48. Zeuzem S, "Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B", J Hepatol, 51, pp.11~20 (2009)
  49. 문영명, "한국인 만성 B형간염 환자에 대한 텔비부딘의 효능 및 안전성", Clinical and Molecular Hepatology, 13(4), pp.503~512 (2007), 대한간학회
  50. Lok AS, "Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management", Hepatology, 46, pp.254~265 (2007)
  51. Marcellin P, "Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B", N Engl J Med, 359, pp.2442~2455 (2008)
  52. Heathcote EJ, "Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B", Gastroenterology, 140, pp.132~143 (2011)
  53. Liaw YF, "Tenofovir disoproxil fumarate (TDF), emtricitabine", TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease, 2011, pp.53, 62~72
  54. van Bömmel F, "Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside", nucleotide analogues, 2010, pp.51, 73~80
  55. Sheldon J, "Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir", Antivir Ther, 10, pp.727~734 (2005)
  56. Amini-Bavil-Olyaee S, "The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains", Hepatology, 49, pp.1158~1165 (2009)
  57. Balakrishna Pai S, "Inhibition of hepatitis B virus by a novel L-nucleoside, 2’-fluoro-5-methyl-beta-L-arabinofuranosyl uracil", Antimicrob Agents Chemother, 40, pp.380~386 (1996)
  58. Chu CK, "Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent", Antivir Ther, 3(Suppl 3), pp.113~121 (1998)
  59. Ma T, "Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents", J Med Chem, 39, pp.2835~2843 (1996)
  60. Yoo BC, "Twenty-four-week clevudine therapy showed potent and sustained antiviral activity in HBeAg-positive chronic hepatitis B", HEPATOLOGY, 45, pp.1172~1178, JOHN WILEY & SONS INC
  61. George KK Lau, "Forty-eight weeks treatment with clevudine 30 mg qd versus lamivudine 100 mg qd for chronic hepatitis B infection: a double-blind randomized study", Clinical and Molecular Hepatology, 16(3), pp.315~320 (2010), 대한간학회
  62. 김인희, "Treatment Outcomes of Clevudine versus Lamivudine at Week 48 in Naive Patients with HBeAg Positive Chronic Hepatitis B", Journal of Korean Medical Science, 25(5), pp.738~745 (2010), 대한의학회
  63. Yoo BC, "Clevudine is highly efficacious in hepatitis B e antigen-negative chronic hepatitis B with durable off-therapy viral suppression", HEPATOLOGY, 46(4), pp.1041~1048, JOHN WILEY SONS INC
  64. Tak WY, "Clinical, biochemical, and pathological characteristics of clevudine-associated myopathy", J Hepatol, 53, pp.261~266 (2010)
  65. Kim HJ, "Comparison between clevudine and entecavir treatment for antiviral-naïve patients with chronic hepatitis B", Liver Int, 30, pp.834~840 (2010)
  66. Kwon SY, "Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients", J Virol, 84, pp.4494~4503 (2010)
  67. 이헌주, "만성 B형간질환에서 핵산유사체 치료경험이 없는 환자와 라미부딘 경험자에서의 클레부딘 치료", Clinical and Molecular Hepatology, 15(2), pp.179~192 (2009), 대한간학회
  68. Chang TT, "Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B", Hepatology, 51, pp.422~430 (2010)
  69. Suzuki F, "Efficacy of switching to entecavir monotherapy in Japanese lamivudine-pretreated patients", J Gastroenterol Hepatol, 52, pp.892~898 (2010)
  70. Yuen MF, "Combination of baseline parameters and on-treatment hepatitis B virus DNA levels to start and continue patients with lamivudine therapy", Antivir Ther, 14, pp.679~685 (2009)
  71. Rapti I, "Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B", Hepatology, 45, pp.307~313 (2007)
  72. Lampertico P, "Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine", Hepatology, 42, pp.1414~1419 (2005)
  73. Lampertico P, "Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients", Gastroenterology, 133, pp.1445~1451 (2007)
  74. 조영주, "라미부딘 내성 만성 B형간염 환자에서 아데포비어 단독요법 후 라미부딘 추가투여의 효과", 대한소화기학회지, 56(2), pp.83~89 (2010), 대한소화기학회
  75. van Bömmel F, "Tenofovir shows limited efficacy in treatment of HBV infections resistant against adefovir", Hepatology, 46(Suppl 1), pp.664A~ (2007)
  76. Patterson SJ, "Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B", Gut, 60, pp.247~254 (2011)
  77. Cho SW, "Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance", J Viral Hepat, 17, pp.171~177 (2010)
  78. Shim JH, "Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone", Hepatology, 50, pp.1064~1071 (2009)
  79. Heo NY, "Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir", J Hepatol, 53, pp.449~454 (2010)
  80. Yang HJ, "Lamivudine and adefovir dipivoxil versus entecavir 1.0 mg alone for the treatment of adefovir-resistant mutation which deveolpoed during sequential adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B", Korean J Hepatol, 15(Suppl 3), pp.S50~ (2009)

관련 논문AI추천

이 간행물의 다른 논문 (22건)