논문KCI 등재
Inhibitory Effect of Dendrobium moniliforme on NO and IL-1β Production in LPS-stimulated Macrophages
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석곡은 난초과의 여러해살이풀 Dendrobium moniliforme의 지상부를 건조한 것으로 예로부터 養胃生津, 滋陰除熱 등의 효능이 있어 해열, 진통의 작용과 위액분비 촉진, 혈압강하의 작용이 있는 것으로 알려져 있다. 본 연구에서는 석곡의 항염증 작용 기전을 알아보기 위하여 석곡 열수추출물을 대식세포주에 처리하여 NO 및 IL-1β의 생성에 미치는 영향을 조사하였다. LPS로 자극된 대식세포주 RAW264.7 세포에서 석곡은 NO 및 IL-1β 생성과 iNOS 단백질 발현을 저해하였으며, LPS에 의해서 활성화되는 ERK, p38, JNK 효소의 활성을 현저히 억제하였다. 이 결과들로 보아 석곡의 항염증 작용이 MAPK 활성 저해로 인한 NO 및 IL-1β 생성의 억제 때문인 것으로 사료된다.
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