논문KCI 등재
LPS로 자극된 대식세포에서 포공영의 NO 생성 억제 효과
Inhibitory Effect of Taraxacum mongolicums (蒲公英) on NO Production in LPS-stimulated Macrophages
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참고문헌
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초록
포공영(蒲公英)은 예로부터 淸熱解毒藥으로 사용되어 왔으며 NO가 염증의 한 요인이기 때문에 포공영의 항염증 작용기작을 밝히기 위하여 LPS로 자극된 대식세포주 RAW264.7 세포에서 포공영 열수 추출물 (AETM)의 NO 생성에 미치는 효과를 조사하였다. 포공영은 NO 생성 및 iNOS 단백질 발현, iNOS mRNA 발현을 저해하였으며, 전사인자인 NF-κB의 핵으로의 이동을 억제하였다. 또한 LPS에 의해서 활성화되는 ERK/MAPK 효소의 활성을 현저히 억제하였다. 이 결과들로 보아 포공영의 항염증 작용이 ERK/MAPK 활성 저해 및 NF-κB 활성 저해로 인한 iNOS 발현의 억제 때문인 것으로 사료된다.
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