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The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea

조성진|김형수|김경호|이진헌|장명국|김학양|신운건|Ha Jung Kim
거트앤리버 소화기연관학회협의회|2012.07|Gut and Liver|제6권 제3호|pp. 321-327|DOI http://dx.doi.org/

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키워드

COX-2PolymorphismStomach neoplasmsDiffuse type

초록

Background/Aims: The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition. Methods: We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms. Results: The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confi dence interval, 1.077 to 35.870). Conclusions: The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.

Abstract

Background/Aims: The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition. Methods: We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms. Results: The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confi dence interval, 1.077 to 35.870). Conclusions: The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.

참고문헌 (39)

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