본문 바로가기
KERD
논문KCI 등재

Helicobacter pylori Seropositivity Is Associated with Gastric Cancer Regardless of Tumor Subtype in Korea

김영우|남병호|최일주|Jun Ho Lee|성문우|Jong Seok Lee|국명철|Keun Won Ryu|Jong Yeul Lee|Chan Gyoo Kim|조수정|Sook Ryun Park|Young-Iee Park
거트앤리버 소화기연관학회협의회|2010.12|Gut and Liver|제4권 제4호|pp. 466-474

2

조회

0

다운로드

6

인용

0

참고문헌

초록

Background/Aims: To evaluate the association between Helicobacter pylori (H. pylori) infection and gastric cancer (GC) according to tumor subtype in Korea. Methods: H. pylori status was determined serologically using the enzyme-linked immunosorbent assay. In total, 2,819 patients with GC and 562 healthy controls were studied. A logistic regression method was used after adjusting for possible confounders. Results: The prevalence of H. pylori infection was significantly higher in the GC patients (84.7%) than in the controls (66.7%) (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.46-3.97). The adjusted OR was significantly higher in H.-pylori-infected patients aged ＜60 years (OR, 4.69; 95% CI, 3.44-6.38) than in those aged ≥60 years (OR, 1.48; 95% CI, 0.88-2.46;p＜0.001). Subgroup analyses revealed no differences in seroprevalence between early gastric cancer (84.8%; OR, 3.01; 95% CI, 2.27-4.01) and advanced gastric cancer (84.6%; OR, 2.94; 95% CI, 2.24-3.85),cardia cancer (83.8%; OR, 2.98; 95% CI, 2.16-4.02)and noncardia cancer (84.8%; OR, 3.17; 95% CI,2.48-4.04), and differentiated carcinoma (82.7%; OR,2.99; 95% CI, 2.21-4.04) and undifferentiated carcinoma (86.8%; OR, 3.05; 95% CI, 2.32-4.00). Conclusions: The seroprevalence of H. pylori was higher in GC patients than in healthy controls, especially in younger patients. H. pylori infection is associated with GC, regardless of the tumor location,stage, or differentiation

Abstract

Background/Aims: To evaluate the association between Helicobacter pylori (H. pylori) infection and gastric cancer (GC) according to tumor subtype in Korea. Methods: H. pylori status was determined serologically using the enzyme-linked immunosorbent assay. In total, 2,819 patients with GC and 562 healthy controls were studied. A logistic regression method was used after adjusting for possible confounders. Results: The prevalence of H. pylori infection was significantly higher in the GC patients (84.7%) than in the controls (66.7%) (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.46-3.97). The adjusted OR was significantly higher in H.-pylori-infected patients aged ＜60 years (OR, 4.69; 95% CI, 3.44-6.38) than in those aged ≥60 years (OR, 1.48; 95% CI, 0.88-2.46;p＜0.001). Subgroup analyses revealed no differences in seroprevalence between early gastric cancer (84.8%; OR, 3.01; 95% CI, 2.27-4.01) and advanced gastric cancer (84.6%; OR, 2.94; 95% CI, 2.24-3.85),cardia cancer (83.8%; OR, 2.98; 95% CI, 2.16-4.02)and noncardia cancer (84.8%; OR, 3.17; 95% CI,2.48-4.04), and differentiated carcinoma (82.7%; OR,2.99; 95% CI, 2.21-4.04) and undifferentiated carcinoma (86.8%; OR, 3.05; 95% CI, 2.32-4.00). Conclusions: The seroprevalence of H. pylori was higher in GC patients than in healthy controls, especially in younger patients. H. pylori infection is associated with GC, regardless of the tumor location,stage, or differentiation

참고문헌 (60)

  1. You WC, "Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors", J Natl Cancer Inst, 92, pp.1607~1612 (2000)
  2. Uemura N, "Helicobacter pylori infection and the development of gastric cancer", N Engl J Med, 345, pp.784~789 (2001)
  3. Crespi M, "Helicobacter pylori and gastric cancer:an overrated risk?", Scand J Gastroenterol, 31, pp.1041~1046 (1996)
  4. Shin A, "A nested case-control study of the association of Helicobacter pylori infection with gastric adenocarcinoma in Korea", Br J Cancer, 92, pp.1273~1275 (2005)
  5. Holcombe C, "Helicobacter pylori: the African enigma", Gut, 33, pp.429~431 (1992)
  6. Singh K, "Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma", World J Gastroenterol, 12, pp.1346~1351 (2006)
  7. Parkin DM, "Global cancer statistics, 2002", CA Cancer J Clin, 55, pp.74~108 (2005)
  8. Hai-Rim Shin, "Nationwide Cancer Incidence in Korea, 1999~2001; First Result Using the National Cancer Incidence Database", Cancer Research and Treatment, 37(6), pp.325~331 (2005), 대한암학회
  9. Yim JY, "Seroprevalence of Helicobacter pylori in South Korea", Helicobacter, 12, pp.333~340 (2007)
  10. Kim JH, "Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea", J Gastroenterol Hepatol, 16, pp.969~975 (2001)
  11. Chang WK, "Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study", J Gastroenterol, 36, pp.816~822 (2001)
  12. Lee SA, "Effect of diet and Helicobacter pylori infection to the risk of early gastric cancer", J Epidemiol, 13, pp.162~168 (2003)
  13. Kim HY, "Helicobacter pylori infection and the risk of gastric cancer among the Korean population", J Gastroenterol Hepatol, 12, pp.100~103 (1997)
  14. Parsonnet J, "Helicobacter pylori infection and the risk of gastric carcinoma", N Engl J Med, 325, pp.1127~1131 (1991)
  15. Kamangar F, "Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity", J Natl Cancer Inst, 98, pp.1445~1452 (2006)
  16. Limburg P, "Helicobacter pylori seropositivity and subsite-specific gastric cancer risks in Linxian, China", J Natl Cancer Inst, 93, pp.226~233 (2001)
  17. Parsonnet J, "Helicobacter pylori infection in intestinal- and diffuse-type gastric adenocarcinomas", J Natl Cancer Inst, 83, pp.640~643 (1991)
  18. Hansson LR, "Prevalence of Helicobacter pylori infection in subtypes of gastric cancer", Gastroenterology, 109, pp.885~888 (1995)
  19. Kato M, "Relationship between Helicobacter pylori infection and the prevalence, site and histological type of gastric cancer", Aliment Pharmacol Ther, 20(Suppl 1), pp.85~88 (2004)
  20. Huang JQ, "Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer", Gastroenterology, 114, pp.1169~1179 (1998)
  21. Lunet N, "Helicobacter pylori infection and gastric cancer: facing the enigmas", Int J Cancer, 106, pp.953~960 (2003)
  22. Derakhshan MH, "Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer", Gut, 57(`), pp.298~305 (2008)
  23. Kajitani T, "The general rules for the gastric cancer study in surgery and pathology. Part I. Clinical classification", Jpn J Surg, 11, pp.127~139 (1981)
  24. Lauren P, "The two histological main types of gastric carcinoma:diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification", Acta Pathol Microbiol Scand, 64, pp.31~49 (1965)
  25. Japanese Gastric Cancer Association, "Japanese classification of gastric carcinoma - 2nd English edition", Gastric Cancer, 1, pp.10~24 (1998)
  26. Eom HS, "Evaluation of four commercial enzyme immunoassay for detection of Helicobacter pylori infection", Korean J Gastroenterol, 37, pp.312~318 (2001)
  27. Schistosomes, "Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks toHumans. Lyon, 7-14 June 1994", IARC Monogr Eval Carcinog Risks Hum, 61, pp.1~241 (1994)
  28. Helicobacter and Cancer Collaborative Group, "Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts", Gut, 49, pp.347~353 (2001)
  29. Karnes WE Jr, "Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis", Gastroenterology, 101, pp.167~174 (1991)
  30. Wang C, "The association between Helicobacter pylori infection and early gastric cancer: a meta-analysis", Am J Gastroenterol, 102, pp.1789~1798 (2007)
  31. Tsukuma H, "Prospective study of "early" gastric cancer", Int J Cancer, 31, pp.421~426 (1983)
  32. Genta RM, "Adherence of Helicobacter pylori to areas of incomplete intestinal metaplasia in the gastric mucosa", Gastroenterology, 111, pp.1206~1211 (1996)
  33. Chow WH, "An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma", Cancer Res, 58, pp.588~590 (1998)
  34. Ye W, "Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia", J Natl Cancer Inst, 96, pp.388~396 (2004)
  35. Richter JE, "Helicobacter pylori and gastroesophageal reflux disease: the bug may not be all bad", Am J Gastroenterol, 93, pp.1800~1802 (1998)
  36. Lagergren J, "Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk?", Gut, 54(Suppl 1), pp.i1~i5 (2005)
  37. Devesa SS, "Changing patterns in the incidence of esophageal and gastric carcinoma in the United States", Cancer, 83, pp.2049~2053 (1998)
  38. Wijnhoven BP, "Increased incidence of adenocarcinomas at the gastro-oesophageal junction in Dutch males since the 1990s", Eur J Gastroenterol Hepatol, 14, pp.115~122 (2002)
  39. Correa P, "Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention", Cancer Res, 52, pp.6735~6740 (1992)
  40. Ohata H, "Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer", Int J Cancer, 109, pp.138~143 (2004)
  41. Tatsuta M, "The association of Helicobacter pylori with differentiated-type early gastric cancer", Cancer, 72, pp.1841~1845 (1993)
  42. Iseki K, "Helicobacter pylori infection in patients with early gastric cancer by the endoscopic phenol red test", Gut, 42, pp.20~23 (1998)
  43. Sasazuki S, "Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study", Cancer Epidemiol Biomarkers Prev, 15, pp.1341~1347 (2006)
  44. Craanen ME, "Helicobacter pylori and early gastric cancer", Gut, 35, pp.1372~1374 (1994)
  45. Linton PJ, "Age-related changes in lymphocyte development and function", Nat Immunol, 5, pp.133~139 (2004)
  46. Nakamura T, "A clinicopathological study in young patients with gastric carcinoma", J Surg Oncol, 71, pp.214~219 (1999)
  47. Lo SS, "Poorer prognosis in young patients with gastric cancer?", Hepatogastroenterology, 46, pp.2690~2693 (1999)
  48. Wang JY, "Clinicopathologic study of advanced gastric cancer without serosal invasion in young and old patients", J Surg Oncol, 63, pp.36~40 (1996)
  49. Yokota T, "Early gastric cancer in the young: clinicopathological study", Aust N Z J Surg, 69, pp.443~446 (1999)
  50. Medina-Franco H, "Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study", Ann Surg Oncol, 7, pp.515~519 (2000)
  51. Kim DY, "Clinicopathologic characteristics of gastric carcinoma in elderly patients: a comparison with young patients", World J Gastroenterol, 11, pp.22~26 (2005)
  52. Bani-Hani KE, "Clinicopathological comparison between young and old age patients with gastric adenocarcinoma", Int J Gastrointest Cancer, 35, pp.43~52 (2005)
  53. Kim JH, "Incidence and long-term outcome of young patients with gastric carcinoma according to sex: does hormonal status affect prognosis?", Arch Surg, 143, pp.1062~1067 (2008)
  54. Matsui M, "The prognosis of patients with gastric cancer possessing sex hormone receptors", Surg Today, 22, pp.421~425 (1992)
  55. Furukawa H, "Gastric cancer in young adults: growth accelerating effect of pregnancy and delivery", J Surg Oncol, 55, pp.3~6 (1994)
  56. Maeta M, "Gastric cancer in the young, with special reference to 14 pregnancy-associated cases: analysis based on 2,325 consecutive cases of gastric cancer", J Surg Oncol, 58, pp.191~195 (1995)
  57. Lindblad M, "Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden", Cancer Epidemiol Biomarkers Prev, 13, pp.2203~2207 (2004)
  58. Romero-Gallo J, "Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and Cag A antigens", Clin Diagn Lab Immunol, 9, pp.1313~1317 (2002)
  59. Chang YW, "Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients", Int J Cancer, 101, pp.469~474 (2002)
  60. Klaamas K, "IgG immune response to Helicobacter pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting", Int J Cancer, 67, pp.1~5 (1996)

관련 논문AI추천

Helicobacter pylori Infection and Risk of Gastric Cancer in Korea: A Quantitative Systematic Review김은희, 배종면대한예방의학회 · 예방의학회지2016 · 제49권 제4호Population Attributable Fraction of Helicobacter pylori Infection–Related Gastric Cancer in Korea: A Meta-Analysis박윤, 기모란대한암학회 · Cancer Research and Treatment2021 · 제53권 제3호Comparison between Resectable Helicobacter pylori -Negative and -Positive Gastric Cancers윤혁, 권용환, 김나영, 김형호, 김희진, 박도중, 박영수, 신철민, 윤기철, 이동호, 이주엽, 이혜승, 조현진, 최윤진거트앤리버 소화기연관학회협의회 · Gut and Liver2016 · 제10권 제2호Postoperative Helicobacter pylori Infection as a Prognostic Factor for Gastric Cancer Patients after Curative Resection김지현, 김형일, 노성훈, 박준철, 신성관, 이상길, 이용찬, 정다현, 정현수, 형우진거트앤리버 소화기연관학회협의회 · Gut and Liver2017 · 제11권 제5호Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection박수경, 안충현, 유근영, 임민경, 장성훈, 장지은, 조은정, 최정빈, 황윤지, Elisabete Weiderpass, Hai-Rim Shin대한암학회 · Cancer Research and Treatment2019 · 제51권 제3호Helicobacter pylori Infection Status and Gastric Tumor Incidence According to the Year of Birth성인경, Kim Jeong Hwan, Lee Sun-Young, Na Jong Hwa, Park Hyung Seok거트앤리버 소화기연관학회협의회 · Gut and Liver2024 · 제18권 제3호

이 간행물의 다른 논문 (17건)

The Molecular Targets for the Diagnosis and Treatment of Pancreatic CancerMuhammad Wasif Saif, Kostas N. Syrigos, Alexios S. Strimpakospp. 433-449Pancreas TransplantationDavid ER Sutherland, 한덕종pp. 450-465Low Levels of Pepsinogen I and Pepsinogen I/II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic MucosectomyGin Hyug Lee, Jin-Ho Kim, Mi-Jung Kim, Young Soo Park, Se Jin Jang, Sun-Mi Lee, Hwoon-Yong Jung, Kee Don Choi, Ho June Song, Sung-Cheol Yunpp. 475-480A Matched Case-Control Study Using the Propensity Score on Differences in the Characteristics of Colorectal Polyps between Younger and Older Koreans: Proximal Shift in the Distribution of Colorectal Polyps among Older KoreansHee Ju Oh, Hee Jung Moon, Yong Gil Kim, 김태년, Hye Mi Lee, 장병익, Dong Hee Kimpp. 481-487Near-Infrared Fluorescence Imaging Using a Protease-Specific Probe for the Detection of Colon TumorsSeung-Jae Myung, Jeong-Sik Byeon, Do Hoon Kim, Suk-Kyun Yang, Byong Duk Ye, Young Soo Park, Jin-Ho Kim, Soon Man Yoon, Nam Gon Lee, Yeon Mi Ryu, Kwangmeyung Kim, Ick Chan Kwon, Mi Young Do, 문대혁, 김인화, 박경순pp. 488-497
원문 보기