IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection.
Abstract
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection.
참고문헌 (17)
- Ghazale A, "Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy", Gastroenterology, 134, pp.706~715 (2008)
- Kamisawa T, "Recent advances in autoimmune pancreatitis: type 1 and type 2", Gut, 62, pp.1373~1380 (2013)
- Hamano H, "Immunoglobulin G4-related lymphoplasmacytic sclerosing cholangitis that mimics infiltrating hilar cholangiocarcinoma: part of a spectrum of autoimmune pancreatitis?", Gastrointest Endosc, 62, pp.152~157 (2005)
- Vosskuhl K, "Measurement of IgG4 in bile: a new approach for the diagnosis of IgG4-associated cholangiopathy", Endoscopy, 44, pp.48~52 (2012)
- Rosen CB, "Liver transplantation for cholangiocarcinoma", Transpl Int, 23, pp.692~697 (2010)
- Zaydfudim VM, "Hilar cholangiocarcinoma", Surg Oncol Clin N Am, 23, pp.247~263 (2014)
- Heimbach JK, "Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination", HPB, 13, pp.356~360 (2011)
- de Groen PC, "Biliary tract cancers", N Engl J Med, 341, pp.1368~1378 (1999)
- Khan SA, "Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update", Gut, 61, pp.1657~1669 (2012)
- Patel AH, "The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis", Am J Gastroenterol, 95, pp.204~207 (2000)
- Barr Fritcher EG, "Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy", Am J Clin Pathol, 128, pp.272~279 (2007)
- Razumilava N, "Classification, diagnosis, and management of cholangiocarcinoma", Clin Gastroenterol Hepatol, 11, pp.13~21 (2013)
- Naitoh I, "Endoscopic transpapillary intraductal ultrasonography and biopsy in the diagnosis of IgG4-related sclerosing cholangitis", J Gastroenterol, 44, pp.1147~1155 (2009)
- Kawakami H, "IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater’s ampulla and the bile duct", J Gastroenterol Hepatol, 25, pp.1648~1655 (2010)
- Zen Y, "IgG4 Cholangiopathy", Int J Hepatol, 2012, pp.472376~ (2012)
- Baskin-Bey ES, "Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma", HPB, 7, pp.283~288 (2005)
- Chari ST, "A diagnostic strategy to distinguish autoimmune pancreatitis from pancreatic cancer", Clin Gastroenterol Hepatol, 7, pp.1097~1103 (2009)