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CpG Island Methylator Phenotype-High Colorectal Cancers and Their Prognostic Implications and Relationships with the Serrated Neoplasia Pathway

강경훈|김경주|이예영
거트앤리버 소화기연관학회협의회|2017.01|Gut and Liver|제11권 제1호|pp. 38-46

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키워드

Colon cancerColorectal cancerMicrosatellite instabilityCpG island methylator henotypeSerrated neoplasia

초록

The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations. CIMP-H CRCs arise in sessile or traditional serrated adenomas and thus tend to display the morphological characteristics of serrated adenomas, including epithelial serration, vesicular nuclei, and abundant cytoplasm. Both the frequent association of CIMP and poor prognosis and different responses of CRCs to adjuvant therapy depending on CIMP status indicate clinical implications. In this review, we present an overview of the literature documenting the relevant findings of CIMP-H CRCs and their relationships with the serrated neoplasia pathway.

Abstract

The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations. CIMP-H CRCs arise in sessile or traditional serrated adenomas and thus tend to display the morphological characteristics of serrated adenomas, including epithelial serration, vesicular nuclei, and abundant cytoplasm. Both the frequent association of CIMP and poor prognosis and different responses of CRCs to adjuvant therapy depending on CIMP status indicate clinical implications. In this review, we present an overview of the literature documenting the relevant findings of CIMP-H CRCs and their relationships with the serrated neoplasia pathway.

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관련 논문AI추천

CpG Island Methylation in Sessile Serrated Adenoma/Polyp of the Colorectum: Implications for Differential Diagnosis of Molecularly High-Risk Lesions among Non-dysplastic Sessile Serrated Adenomas/Polyps강경훈, 김정호, 박혜은, 유승연, 이지애, 정서린, 조남윤대한병리학회 · Journal of Pathology and Translational Medicine2019 · 제53권 제4호Molecular Features of the Serrated Pathway to Colorectal Cancer: Current Knowledge and Future DirectionsBustamante-Balén Marco, García-Campos María, Satorres Carla거트앤리버 소화기연관학회협의회 · Gut and Liver2021 · 제15권 제1호Evolving pathologic concepts of serrated lesions of the colorectum강경훈, 김정호대한병리학회 · Journal of Pathology and Translational Medicine2020 · 제54권 제4호Pathogenesis and Management of Serrated Polyps: Current Status and Future DirectionsJoseph C. Anderson거트앤리버 소화기연관학회협의회 · Gut and Liver2014 · 제8권 제6호The Role of the CpG Island Methylator Phenotype on Survival Outcome in Colon Cancer강기주, 김경미, 김영호, 김재준, 류경주, 민병훈, 이종철, 장동경거트앤리버 소화기연관학회협의회 · Gut and Liver2015 · 제9권 제2호Prognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer주영은거트앤리버 소화기연관학회협의회 · Gut and Liver2015 · 제9권 제2호

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