What Are the Risk Factors for Acute Suppurative Cholangitis Caused by Common Bile Duct Stones?
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severe form of acute cholangitis, is a life-threatening condition that must be treated with appropriate and timely management. The purpose of this study was to identify the factors that predispose patients to ASC. Methods: We retrospectively investigated 181patients (100 men, 81 women; age, 70.66±7.38 years,mean±SD) who were admitted to Wonkwang University Hospital between January 2005 and June 2007for acute cholangitis with common bile duct (CBD)stones. All patients underwent endoscopic retrograde cholangiopancreatogram to remove the stones. Variables and factors that could be assessed upon admission were analyzed to identify the risk factors for the development of ASC. Results: Of the 181 patients,44 (24.3%) presented with ASC. On multivariate analysis, the followings were found to be independent risk factors for the development of ASC:impacted common bile duct stone (p=0.010), current smoker status (p=0.008), advanced age (＞70 years;p=0.002), and gallstone (p=0.016). The most commonly isolated organisms in bile culture were Enterococcus species, Escherichia coli, and Klebsiella species. Conclusions: Impacted bile-duct stones, current smoking, advanced age, and gallstones were identified as independent risk factors for the development of ASC in patients with CBD stones. These results suggest that emergency biliary drainage is beneficial in patients with these risk factors.
Abstract
severe form of acute cholangitis, is a life-threatening condition that must be treated with appropriate and timely management. The purpose of this study was to identify the factors that predispose patients to ASC. Methods: We retrospectively investigated 181patients (100 men, 81 women; age, 70.66±7.38 years,mean±SD) who were admitted to Wonkwang University Hospital between January 2005 and June 2007for acute cholangitis with common bile duct (CBD)stones. All patients underwent endoscopic retrograde cholangiopancreatogram to remove the stones. Variables and factors that could be assessed upon admission were analyzed to identify the risk factors for the development of ASC. Results: Of the 181 patients,44 (24.3%) presented with ASC. On multivariate analysis, the followings were found to be independent risk factors for the development of ASC:impacted common bile duct stone (p=0.010), current smoker status (p=0.008), advanced age (＞70 years;p=0.002), and gallstone (p=0.016). The most commonly isolated organisms in bile culture were Enterococcus species, Escherichia coli, and Klebsiella species. Conclusions: Impacted bile-duct stones, current smoking, advanced age, and gallstones were identified as independent risk factors for the development of ASC in patients with CBD stones. These results suggest that emergency biliary drainage is beneficial in patients with these risk factors.
참고문헌 (18)
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