본문 바로가기
KERD
논문KCI 등재

Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

초록

Despite substantial progress in screening, early diagnosis,and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic approach for reducing the global burden of GI cancer, and efforts have been made to search for chemopreventive agents that suppress acid reflux, GI inflammation and the eradication of Helicobacter pylori. Thus, proton pump inhibitors,statins, monoclonal antibodies targeting tumor necrosis factor-alpha, and nonsteroidal anti-inflammatory agents have been investigated for their potential to prevent GI cancer. Besides the development of these synthetic agents,a wide variety of the natural products present in a plantbased diet, which are commonly called phytoceuticals, have also sparked hope for the chemoprevention of GI cancer. To perform successful searches of chemopreventive agents for GI cancer, it is of the utmost importance to understand the factors contributing to GI carcinogenesis. Emerging evidence has highlighted the role of chronic inflammation in inducing genomic instability and telomere shortening and affecting polyamine metabolism and DNA repair, which may help in the search for new chemopreventive agents for GI cancer.

Abstract

Despite substantial progress in screening, early diagnosis,and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic approach for reducing the global burden of GI cancer, and efforts have been made to search for chemopreventive agents that suppress acid reflux, GI inflammation and the eradication of Helicobacter pylori. Thus, proton pump inhibitors,statins, monoclonal antibodies targeting tumor necrosis factor-alpha, and nonsteroidal anti-inflammatory agents have been investigated for their potential to prevent GI cancer. Besides the development of these synthetic agents,a wide variety of the natural products present in a plantbased diet, which are commonly called phytoceuticals, have also sparked hope for the chemoprevention of GI cancer. To perform successful searches of chemopreventive agents for GI cancer, it is of the utmost importance to understand the factors contributing to GI carcinogenesis. Emerging evidence has highlighted the role of chronic inflammation in inducing genomic instability and telomere shortening and affecting polyamine metabolism and DNA repair, which may help in the search for new chemopreventive agents for GI cancer.

참고문헌 (162)

  1. Mann JR, "Mechanisms of disease: inflammatory mediators and cancer prevention", Nat Clin Pract Oncol, 2, pp.202~210 (2005)
  2. Wattenberg LW, "Chemoprophylaxis of carcinogenesis: a review", Cancer Res, 26, pp.1520~1526 (1966)
  3. Sporn MB, "Approaches to prevention of epithelial cancer during the preneoplastic period", Cancer Res, 36(7 Pt 2), pp.2699~2702 (1976)
  4. Surh YJ, "Cancer chemoprevention with dietary phytochemicals", Nat Rev Cancer, 3, pp.768~780 (2003)
  5. Moolgavkar SH, "The multistage theory of carcinogenesis and the age distribution of cancer in man", J Natl Cancer Inst, 61, pp.49~52 (1978)
  6. Gravitz L, "Chemoprevention: first line of defence", Nature, 471, pp.S5~S7 (2011)
  7. Stoner GD, "Chemoprevention of esophageal squamous cell carcinoma", Toxicol Appl Pharmacol, 224, pp.337~349 (2007)
  8. Pera M, "Epidemiology of esophageal adenocarcinoma", J Surg Oncol, 92, pp.151~159 (2005)
  9. Brown LM, "Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age", J Natl Cancer Inst, 100, pp.1184~1187 (2008)
  10. Jemal A, "Global cancer statistics", CA Cancer J Clin, 61, pp.69~90 (2011)
  11. Jemal A, "Trends in the leading causes of death in the United States, 1970-2002", JAMA, 294, pp.1255~1259 (2005)
  12. Jemal A, "Cancer statistics, 2009", CA Cancer J Clin, 59, pp.225~249 (2009)
  13. Moshkowitz M, "Chemoprevention for advanced CR neoplasia", Best Pract Res Clin Gastroenterol, 25, pp.623~630 (2011)
  14. Garcia-Albeniz X, "Aspirin for the prevention of colorectal cancer", Best Pract Res Clin Gastroenterol, 25, pp.461~472 (2011)
  15. Eaden J, "Colorectal cancer prevention in ulcerative colitis: a case-control study", Aliment Pharmacol Ther, 14, pp.145~153 (2000)
  16. DuBois RN, "Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention", Gastroenterol Clin North Am, 25, pp.773~791 (1996)
  17. Bartsch T, "Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus", Pain, 117, pp.30~39 (2005)
  18. Nair J, "Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn’s disease, ulcerative colitis, and chronic pancreatitis", Antioxid Redox Signal, 8, pp.1003~1010 (2006)
  19. Seril DN, "Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models", Carcinogenesis, 24, pp.353~362 (2003)
  20. Ohshima H, "8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis", Antioxid Redox Signal, 8, pp.1033~1045 (2006)
  21. Yermilov V, "Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro", Carcinogenesis, 16, pp.2045~2050 (1995)
  22. Kawanishi S, "Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis", Biol Chem, 387, pp.365~372 (2006)
  23. Wild CP, "Reflux, Barrett’s oesophagus and adenocarcinoma: burning questions", Nat Rev Cancer, 3, pp.676~684 (2003)
  24. Prior P, "Cancer morbidity in ulcerative colitis", Gut, 23, pp.490~497 (1982)
  25. Rhim AD, "EMT and dissemination precede pancreatic tumor formation", Cell, 148, pp.349~361 (2012)
  26. Guerra C, "Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence", Cancer Cell, 19, pp.728~739 (2011)
  27. Yang Y, "Genomic instability in precancerous lesions before inactivation of tumor suppressors p53 and APC in patients", Cell Cycle, 5, pp.1443~1447 (2006)
  28. Park WS, "Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis", Int J Mol Med, 2, pp.221~224 (1998)
  29. Brentnall TA, "Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis", Cancer Res, 55, pp.4264~4267 (1995)
  30. Moskovitz AH, "Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma", Genes Chromosomes Cancer, 37, pp.201~206 (2003)
  31. Werling K, "Effect of hepatitis C virus on hepatocyte proliferation and DNA ploidy in patients with chronic hepatitis C", Z Gastroenterol, 38, pp.553~558 (2000)
  32. Isokawa O, "Reduction of telomeric repeats as a possible predictor for development of hepatocellular carcinoma: convenient evaluation by slot-blot analysis", Hepatology, 30, pp.408~412 (1999)
  33. Hou L, "Telomere length in peripheral leukocyte DNA and gastric cancer risk", Cancer Epidemiol Biomarkers Prev, 18, pp.3103~3109 (2009)
  34. Risques RA, "Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation", Cancer Res, 71, pp.1669~1679 (2011)
  35. Meira LB, "DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice", J Clin Invest, 118, pp.2516~2525 (2008)
  36. Kohonen-Corish MR, "Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors", Cancer Res, 62, pp.2092~2097 (2002)
  37. Taniguchi K, "Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice", Oncology, 71, pp.124~130 (2006)
  38. Edwards RA, "Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer", Cancer Res, 69, pp.6423~6429 (2009)
  39. Liao J, "Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice", Mol Carcinog, 47, pp.638~646 (2008)
  40. Jaiswal M, "Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis", Am J Physiol Gastrointest Liver Physiol, 281, pp.G626~G634 (2001)
  41. Hofseth LJ, "The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation", J Clin Invest, 112, pp.1887~1894 (2003)
  42. Ando K, "A new APE1", Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity, 2008, pp.36, 4327~4336
  43. Meyskens FL Jr, "Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial", Cancer Prev Res (Phila), 1, pp.32~38 (2008)
  44. Gobert AP, "Helicobacter pylori induces macrophage apoptosis by activation of arginase II", J Immunol, 168, pp.4692~4700 (2002)
  45. Koza RA, "Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas", Carcinogenesis, 12, pp.1619~1625 (1991)
  46. ter Steege JC, "Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model", Shock, 11, pp.115~119 (1999)
  47. Alhonen L, "Activation of polyamine catabolism in transgenic rats induces acute pancreatitis", Proc Natl Acad Sci U S A, 97, pp.8290~8295 (2000)
  48. Rasanen TL, "A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism", J Biol Chem, 277, pp.39867~39872 (2002)
  49. Babbar N, "Inflammation and polyamine catabolism: the good, the bad and the ugly", Biochem Soc Trans, 35(Pt 2), pp.300~304 (2007)
  50. Xu H, "Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis", Cancer Res, 64, pp.8521~8525 (2004)
  51. Endo Y, "Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers", J Gastroenterol, (46 Suppl 1), pp.6~10 (2011)
  52. Matsumoto Y, "Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium", Nat Med, 13, pp.470~476 (2007)
  53. Takaishi S, "Providing AID to p53 mutagenesis", Nat Med, 13, pp.404~406 (2007)
  54. Kou T, "Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis", Int J Cancer, 120, pp.469~476 (2007)
  55. Shimizu T, "Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis", Cancer Sci, 103, pp.1201~1206 (2012)
  56. Marusawa H, "Role of activation-induced cytidine deaminase in inflammation-associated cancer development", Adv Immunol, 111, pp.109~141 (2011)
  57. Hillman LC, "Proton-pump inhibitor therapy and the development of dysplasia in patients with Barrett’s oesophagus", Med J Aust, 180, pp.387~391 (2004)
  58. Hillman LC, "Effect of proton pump inhibitors on markers of risk for high-grade dysplasia and oesophageal cancer in Barrett’s oesophagus", Aliment Pharmacol Ther, 27, pp.321~326 (2008)
  59. Miyashita T, "Rabeprazole impedes the development of reflux-induced esophageal cancer in a surgical rat model", Dig Dis Sci, 56, pp.1309~1314 (2011)
  60. Garcia Rodriguez LA, "Gastric acid suppression and risk of oesophageal and gastric adenocarcinoma: a nested case control study in the UK", Gut, 55, pp.1538~1544 (2006)
  61. Obszynska JA, "Long-term proton pump induced hypergastrinaemia does induce lineage-specific restitution but not clonal expansion in benign Barrett’s oesophagus in vivo", Gut, 59, pp.156~163 (2010)
  62. "Novel Application of Proton Pump Inhibitor for the Prevention of Colitis-Induced Colorectal Carcinogenesis beyond Acid Suppression", CANCER PREVENTION RESEARCH, 3(8), pp.963~974 (2010), AMER ASSOC CANCER RESEARCH
  63. "Prevention of Colitis-Associated Carcinogenesis with Infliximab", CANCER PREVENTION RESEARCH, 3(10), pp.1314~1333 (2010), AMER ASSOC CANCER RESEARCH
  64. Yeo M, "Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells", Clin Cancer Res, 10, pp.8687~8696 (2004)
  65. Hahm KB, "Augmented eradication rates of Helicobacter pylori by new combination therapy with lansoprazole, amoxicillin, and rebamipide", Dig Dis Sci, 43, pp.235~240 (1998)
  66. Thun MJ, "The role of aspirin in cancer prevention", Nat Rev Clin Oncol, 9, pp.259~267 (2012)
  67. Burn J, "A randomized placebo-controlled prevention trial of aspirin and", or resistant starch in young people with familial adenomatous polyposis, 2011, pp.4, 655~665
  68. Tang J, "Mesalamine protects against colorectal cancer in inflammatory bowel disease", Dig Dis Sci, 55, pp.1696~1703 (2010)
  69. Rothwell PM, "Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials", Lancet, 379, pp.1591~1601 (2012)
  70. Vaughan TL, "Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study", Lancet Oncol, 6, pp.945~952 (2005)
  71. Tan XL, "Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study", Cancer Prev Res (Phila), 4, pp.1835~1841 (2011)
  72. Bonifazi M, "Aspirin use and pancreatic cancer risk", Eur J Cancer Prev, 19, pp.352~354 (2010)
  73. Menezes RJ, "Regular use of aspirin and pancreatic cancer risk", BMC Public Health, 2, pp.18~ (2002)
  74. So Jung Lee, "Efficacy of Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile Sulfur Compound Levels after Helicobacter pylori Eradication Therapy", Journal of Ginseng Research, 34(2), pp.122~131 (2010), 고려인삼학회
  75. Ki-Seok Choi, "Inhibition of Hydrogen Sulfide-induced Angiogenesis and Inflammation in Vascular Endothelial Cells: Potential Mechanisms of Gastric Cancer Prevention by Korean Red Ginseng", Journal of Ginseng Research, 36(2), pp.135~145 (2012), 고려인삼학회
  76. Park S, "Rescue of Helicobacter pylori-induced cytotoxicity by red ginseng", Dig Dis Sci, 50, pp.1218~1227 (2005)
  77. "Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells", Digestive Diseases and Sciences, 52(4), pp.973~982 (2007), Kluwer Academic[DOI]
  78. 김덕기, "Helicobacter pylori 연관 만성 위염 환자에서 고려홍삼 치료의 효능에 대한 무작위 연구", 대한내과학회지, 72(1), pp.20~28 (2007), 대한내과학회
  79. Wargovich MJ, "Colon cancer chemoprevention with ginseng and other botanicals", J Korean Med Sci, 16, pp.S81~S86 (2001)
  80. Holian O, "Inhibition of gastric cancer cell proliferation by resveratrol: role of nitric oxide", Am J Physiol Gastrointest Liver Physiol, 282, pp.G809~G816 (2002)
  81. Li ZG, "Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol", Carcinogenesis, 23, pp.1531~1536 (2002)
  82. Cui X, "Resveratrol suppresses colitis and colon cancer associated with colitis", Cancer Prev Res (Phila), 3, pp.549~559 (2010)
  83. Roy SK, "Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors", PLoS One, 6, pp.e25166~ (2011)
  84. "Inhibition of intestinal tumorigenesis in Apcmin", + mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea, 2005, pp.65(22), 10623~10631[DOI]
  85. "Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats", CARCINOGENESIS, 29(1), pp.113~119 (2008), OXFORD UNIV PRESS
  86. Sharma RA, "Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer", Clin Cancer Res, 7, pp.1894~1900 (2001)
  87. Sharma RA, "Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance", Clin Cancer Res, 10, pp.6847~6854 (2004)
  88. Cruz-Correa M, "Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis", Clin Gastroenterol Hepatol, 4, pp.1035~1038 (2006)
  89. Delmas D, "Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells", J Biol Chem, 278, pp.41482~41490 (2003)
  90. Liang YC, "Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells", Biochem Pharmacol, 65, pp.1053~1060 (2003)
  91. Ye F, "Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin", World J Gastroenterol, 18, pp.126~135 (2012)
  92. Hou Z, "Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells", Cancer Res, 65, pp.8049~8056 (2005)
  93. Li ZG, "Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats", Int J Oncol, 21, pp.1275~1283 (2002)
  94. Inoue M, "Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies", Gut, 58, pp.1323~1332 (2009)
  95. Gutierrez-Orozco F, "Green and black tea inhibit cytokine-induced IL-8 production and secretion in AGS gastric cancer cells via inhibition of NF-kappaB activity", Planta Med, 76, pp.1659~1665 (2010)
  96. Wu H, "Low-dose docetaxel combined with (-)-epigallocatechin-3-gallate inhibits angiogenesis and tumor growth in nude mice with gastric cancer xenografts", Cancer Biother Radiopharm, 27, pp.204~209 (2012)
  97. Zhu BH, "(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer", World J Gastroenterol, 17, pp.2315~2325 (2011)
  98. Tanaka T, "(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68", Free Radic Biol Med, 50, pp.1324~1335 (2011)
  99. Xu G, "Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis", Food Chem Toxicol, 48, pp.390~395 (2010)
  100. Lambert JD, "Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate", J Agric Food Chem, 58, pp.10016~10019 (2010)
  101. Stingl JC, "Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population", BMC Cancer, 11, pp.360~ (2011)
  102. Larsen CA, "Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide", Biochem Biophys Res Commun, 389, pp.527~530 (2009)
  103. Adachi S, "(-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046", 1047 by p38 MAPK in colon cancer cells, 2009, pp.30, 1544~1552
  104. Shimizu M, "(-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL", KsJ-db, Cancer Prev Res (Phila), pp.2008, 1[DOI]
  105. Wang Z, "Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1", Clin Exp Pharmacol Physiol, 39, pp.227~232 (2012)
  106. Riles WL, "Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells", World J Gastroenterol, 12, pp.5628~5634 (2006)
  107. Atten MJ, "Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism", Biochem Pharmacol, 62, pp.1423~1432 (2001)
  108. Zhou HB, "Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice", World J Gastroenterol, 11, pp.280~284 (2005)
  109. Juan ME, "Colorectal cancer chemoprevention by trans-resveratrol", Pharmacol Res, 65, pp.584~591 (2012)
  110. Panaro MA, "Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-kappaB activation in Caco-2 and SW480 human colon cancer cells", Br J Nutr, 108, pp.1623~1632 (2012)
  111. Miki H, "Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells", Int J Oncol, 40, pp.1020~1028 (2012)
  112. Vanamala J, "Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach", Proteome Sci, 9, pp.49~ (2011)
  113. Radhakrishnan S, "Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis", Front Biosci (Elite Ed), 3, pp.1509~1523 (2011)
  114. Patel KR, "Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients", Cancer Res, 70, pp.7392~7399 (2010)
  115. Tian F, "Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice", Oncol Rep, 28, pp.232~240 (2012)
  116. Subramaniam D, "Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling", PLoS One, 7, pp.e30590~ (2012)
  117. Sintara K, "Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats", J Biomed Biotechnol, 2012, pp.915380~ (2012)
  118. Yu LL, "Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-kappaB transcription factor", Oncol Rep, 26, pp.1197~1203 (2011)
  119. Zaidi SF, "Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells", Helicobacter, 14, pp.588~595 (2009)
  120. Cai XZ, "Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression", Cancer Biol Ther, 8, pp.1360~1368 (2009)
  121. Ja Young Koo, "Curcumin Inhibits the Growth of AGS Human Gastric Carcinoma Cells In Vitro and Shows Synergism with 5-Fluorouracil", Journal of Medicinal Food, 7(2), pp.117~121 (2004), 한국식품영양과학회
  122. Johnson JJ, "Curcumin for chemoprevention of colon cancer", Cancer Lett, 255, pp.170~181 (2007)
  123. Subramaniam D, "Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity", Cancer Res, 68, pp.1962~1969 (2008)
  124. Kanwar SS, "Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells", Pharm Res, 28, pp.827~838 (2011)
  125. Nautiyal J, "Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells", Int J Cancer, 128, pp.951~961 (2011)
  126. Patel BB, "Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R", Anticancer Res, 30, pp.319~325 (2010)
  127. Mudduluru G, "Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer", Biosci Rep, 31, pp.185~197 (2011)
  128. Villegas I, "Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice", Mol Nutr Food Res, 55, pp.259~267 (2011)
  129. Li N, "A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide", Carcinogenesis, 27, pp.1222~1231 (2006)
  130. Yang YH, "Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells", Apoptosis, 11, pp.993~1001 (2006)
  131. Wu PP, "Diallyl trisulfide (DATS) inhibits mouse colon tumor in mouse CT-26 cells allograft model in vivo", Phytomedicine, 18, pp.672~676 (2011)
  132. Hosono T, "Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin", J Biol Chem, 280, pp.41487~41493 (2005)
  133. Parkin DM, "The global health burden of infection-associated cancers in the year 2002", Int J Cancer, 118, pp.3030~3044 (2006)
  134. Pan MH, "Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate", Food Funct, 2, pp.101~110 (2011)
  135. Kumar N, "Green tea polyphenols in the prevention of colon cancer", Front Biosci, 12, pp.2309~2315 (2007)
  136. Zikri NN, "Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells", Nutr Cancer, 61, pp.816~826 (2009)
  137. Surh YJ, "Cancer chemopreventive effects of curcumin", Adv Exp Med Biol, 595, pp.149~172 (2007)
  138. Goel A, "Curcumin as “Curecumin”: from kitchen to clinic", Biochem Pharmacol, 75, pp.787~809 (2008)
  139. Hoshiyama Y, "Green tea and stomach cancer: a short review of prospective studies", J Epidemiol, (15 Suppl 2), pp.S109~S112 (2005)
  140. Tsubono Y, "Green tea and the risk of gastric cancer in Japan", N Engl J Med, 344, pp.632~636 (2001)
  141. Sung B, "Cancer cell signaling pathways targeted by spice-derived nutraceuticals", Nutr Cancer, 64, pp.173~197 (2012)
  142. Kunnumakkara AB, "Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins", Cancer Lett, 269, pp.199~225 (2008)
  143. Aggarwal BB, "Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies", Anticancer Res, 24(5A), pp.2783~2840 (2004)
  144. Chiu HF, "Statins are associated with a reduced risk of gastric cancer: a population-based case-control study", Am J Gastroenterol, 106, pp.2098~2103 (2011)
  145. Kim WS, "Phase II study of high-dose lovastatin in patients with advanced gastric adenocarcinoma", Invest New Drugs, 19, pp.81~83 (2001)
  146. Toyoda T, "Pitavastatin fails to lower serum lipid levels or inhibit gastric carcinogenesis in Helicobacter pylori-infected rodent models", Cancer Prev Res (Phila), 2, pp.751~758 (2009)
  147. Cheng MH, "Statin use and the risk of colorectal cancer: a population-based case-control study", World J Gastroenterol, 17, pp.5197~5202 (2011)
  148. Relja B, "Simvastatin inhibits cell growth and induces apoptosis and G0", G1 cell cycle arrest in hepatic cancer cells, 2010, pp.26, 735~741
  149. Relja B, "Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK", Int J Oncol, 38, pp.879~885 (2011)
  150. Bertkova I, "The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats", Neoplasma, 57, pp.422~428 (2010)
  151. Goossens D, "Probiotics in gastroenterology: indications and future perspectives", Scand J Gastroenterol Suppl, pp.15~23 (2003)
  152. "Prevention of Colitis-Associated Colorectal Cancer with 8-Hydroxydeoxyguanosine", CANCER PREVENTION RESEARCH, 4(9), pp.1507~1521 (2011), AMER ASSOC CANCER RESEARCH
  153. Lim K, "Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids", Cancer Res, 68, pp.553~560 (2008)
  154. "Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2", MOLECULAR CANCER THERAPEUTICS, 8, pp.3046~3055 (2009), AMER ASSOC CANCER RESEARCH
  155. "Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt", Beta-Catenin Signaling, 2011, pp.11(6), 574~584[DOI]
  156. Kang JX, "Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids", Nature, 427, pp.504~ (2004)
  157. Weylandt KH, "Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-alpha", Carcinogenesis, 32, pp.897~903 (2011)
  158. Oh DY, "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects", Cell, 142, pp.687~698 (2010)
  159. Hawcroft G, "The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE(2) -dependent cell motility", Br J Pharmacol, 166, pp.1724~1737 (2012)
  160. Barbosa DS, "Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids", Nutrition, 19, pp.837~842 (2003)
  161. King VR, "Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat", J Neurosci, 26, pp.4672~4680 (2006)
  162. Cockbain AJ, "Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer", Gut, 61, pp.135~149 (2012)

관련 논문AI추천

이 간행물의 다른 논문 (19건)