β-Catenin Activated Hepatocellular Adenoma: A Report of Three Cases in Korea
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Hepatocellular adenoma (HCA) is an uncommon benign hepatictumor, and the use of oral contraceptives is known tocontribute to the development of HCA. Recently, a genotypeand phenotype classification system for HCA was suggested,and malignant transformation to hepatocellular carcinoma(HCC) was shown to be strongly associated with activatingmutations in β-catenin. Here, we report three cases ofHCA in Korean patients: 7-cm, inflammatory and β-cateninactivatedHCA with HCC transformation in a 46-year-old man;13-cm, β-catenin-activated HCA with cytological atypia in a23-year-old woman; and 10-cm, pigmented, inflammatoryand β-catenin-activated HCA in a 36-year-old man. All casesexhibited the nuclear expression of β-catenin and diffusecytoplasmic expression of glutamine synthetase upon immunohistochemicalstaining. All tumors were completelyresected, and the patients were followed for 3 to 6 years withno evidence of local recurrence or metastasis
Abstract
Hepatocellular adenoma (HCA) is an uncommon benign hepatictumor, and the use of oral contraceptives is known tocontribute to the development of HCA. Recently, a genotypeand phenotype classification system for HCA was suggested,and malignant transformation to hepatocellular carcinoma(HCC) was shown to be strongly associated with activatingmutations in β-catenin. Here, we report three cases ofHCA in Korean patients: 7-cm, inflammatory and β-cateninactivatedHCA with HCC transformation in a 46-year-old man;13-cm, β-catenin-activated HCA with cytological atypia in a23-year-old woman; and 10-cm, pigmented, inflammatoryand β-catenin-activated HCA in a 36-year-old man. All casesexhibited the nuclear expression of β-catenin and diffusecytoplasmic expression of glutamine synthetase upon immunohistochemicalstaining. All tumors were completelyresected, and the patients were followed for 3 to 6 years withno evidence of local recurrence or metastasis
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