Hypocholesterolemia in Patients with an Amebic Liver Abscess
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Background/Aims: Many parasites induce changes in thelipid profiles of the host. Cholesterol increases the virulenceof Entamoeba histolytica in animal models and in vitroculture. This study aimed to determine, in patients withan amebic liver abscess, the correlation between cholesteroland other features, such as the size and number ofabscesses, standard hematological and serum chemistryprofiles, liver tests, and duration of hospital stay. Methods: Atotal of 108 patients with an amebic liver abscess and 140clinically healthy volunteers were investigated. Cholesteroland triglycerides were measured in the sera. The data frommedical observations and laboratory tests were obtainedfrom the clinical records. Results: A total of 93% of patientswith an amebic liver abscess showed hypocholesterolemianot related to any of the studied parameters. Liver functiontests correlated with the size of the abscess. The mostsevere cases of amebic liver disease or death were foundin patients whose cholesterol levels continued to decreasedespite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemiaobserved in patients with an amebic liver abscess is not relatedto any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severityof hepatic amebiasis.
Abstract
Background/Aims: Many parasites induce changes in thelipid profiles of the host. Cholesterol increases the virulenceof Entamoeba histolytica in animal models and in vitroculture. This study aimed to determine, in patients withan amebic liver abscess, the correlation between cholesteroland other features, such as the size and number ofabscesses, standard hematological and serum chemistryprofiles, liver tests, and duration of hospital stay. Methods: Atotal of 108 patients with an amebic liver abscess and 140clinically healthy volunteers were investigated. Cholesteroland triglycerides were measured in the sera. The data frommedical observations and laboratory tests were obtainedfrom the clinical records. Results: A total of 93% of patientswith an amebic liver abscess showed hypocholesterolemianot related to any of the studied parameters. Liver functiontests correlated with the size of the abscess. The mostsevere cases of amebic liver disease or death were foundin patients whose cholesterol levels continued to decreasedespite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemiaobserved in patients with an amebic liver abscess is not relatedto any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severityof hepatic amebiasis.
참고문헌 (40)
- Espinosa-Cantellano M, "Pathogenesis of intestinal amebiasis: from molecules to disease", Clin Microbiol Rev, 13, pp.318~331 (2000)
- Katzenstein D, "New concepts of amebic liver abscess derived from hepatic imaging, serodiagnosis, and hepatic enzymes in 67 consecutive cases in San Diego", Medicine (Baltimore), 61, pp.237~246 (1982)
- "Ameobic liver abscess" (1979)[URL]
- Lodhi S, "Features distinguishing amoebic from pyogenic liver abscess: a review of 577 adult cases", Trop Med Int Health, 9, pp.718~723 (2004)
- Bansal D, "Role of cholesterol in parasitic infections", Lipids Health Dis, 4, pp.10~ (2005)
- Das SR, "Restoration of virulence to rat of axenically grown Entamoeba histolytica by cholesterol and hamster liver passage", Ann Trop Med Parasitol, 70, pp.439~443 (1976)
- Gill NJ, "Model of amoebic liver abscess in cholesterol-fed guinea pigs through intracaecal infection route", Indian J Med Res, 78, pp.489~496 (1983)
- Bhatti HS, "An experimental model of ameboma in guinea pig", Exp Parasitol, 74, pp.283~289 (1992)
- Mattern CF, "Virulence of Entamoeba histolytica upon continuous axenic cultivation", Arch Invest Med (Mex), 13(Suppl 3:), pp.185~190 (1982)
- Phillips BP, "Entamoeba histolytica: concurrent irreversible loss of infectivity-pathogenicity and encystment potential after prolonged maintenance in axenic culture in vitro", Exp Parasitol, 34, pp.163~167 (1973)
- Meerovitch E, "Restoration of virulence of axenically cultivated Entamoeba histolytica by cholesterol", Can J Microbiol, 24, pp.63~65 (1978)
- Vinayak VK, "Pathogenicity of Entamoeba histolytica: effect of cholesterol on the virulence of strains of amoebae", Indian J Med Res, 67, pp.545~552 (1978)
- Katiyar SK, "Action of cholesterol on virulence related biochemical functions of Entamoeba histolytica", Indian J Exp Biol, 26, pp.848~850 (1988)
- Serrano-Luna J, "Effect of phosphatidylcholine-cholesterol liposomes on Entamoeba histolytica virulence", Can J Microbiol, 56, pp.987~995 (2010)
- Goldston AM, "Sink or swim: lipid rafts in parasite pathogenesis", Trends Parasitol, 28, pp.417~426 (2012)
- Welter BH, "Localisation to lipid rafts correlates with increased function of the Gal", GalNAc lectin in the human protozoan parasite, Entamoeba histolytica, 2011, pp.41, 1409~1419
- Flores MS, "Preparation of Entamoeba histolytica antigens without enzymatic inhibitors", Parasitology, 131(Pt 2), pp.231~236 (2005)
- Flores-de-Castañeda MS, "Procedure to preserve antigens of Entamoeba histolytica without enzymatic inhibitors", United States patent US 5,459,042. 1995 Oct 17, ~ (1995)
- Flores-de-Castañeda MS, "Universidad Autonoma De Nuevo Leon, assignee. Procedure to preserve antigens of Entamoeba histolytica without enzymatic inhibitors and their use in immunological methods", United States patent 5,861,263. 1999 Jan 19, ~ (1999)
- Flores-de-Castañeda MS, "Procedimiento para la preservación de moléculas antigénicas sin el uso de inhibidores enzimáticos", Mexican patent 209646, ~ (2002)
- Flores-de-Castañeda MS, "Universidad Autonoma De Nuevo Leon, assignee. Procedimiento para la preservación de moléculas antigénicas sin el uso de inhibidores enzimáticos y su aplicación en métodos inmunológicos", Mexican patent 209648, ~ (2002)
- Viranuvatti V, "Liver function test in hepatic amebiasis, based on 274 clinical cases", Am J Gastroenterol, 39, pp.345~361 (1963)
- Magill GB, "Plasma cholinesterase and other liver function tests in hepatic amebiasis", J Lab Clin Med, 51, pp.333~344 (1958)
- Bansal D, "Altered lipid parameters in patients infected with Entamoeba histolytica, Entamoeba dispar and Giardia lamblia", Br J Biomed Sci, 62, pp.63~65 (2005)
- Salako LA, "Liver function tests in the diagnosis of hepatic amoebiasis", J Trop Med Hyg, 70, pp.19~22 (1967)
- Nigam P, "Cholestasis in amoebic liver abscess", Gut, 26, pp.140~145 (1985)
- Salles JM, "Hepatic amebiasis", Braz J Infect Dis, 7, pp.96~110 (2003)
- Gujral S, "Altered lipid profile in liver amoebiasis and its emendation with metronidazole treatment", Indian J Physiol Pharmacol, 26, pp.240~245 (1982)
- Das S, "Lipid metabolism in mucous-dwelling a mitochondriate protozoa", Int J Parasitol, 32, pp.655~675 (2002)
- Das S, "Phospholipid remodeling", generation in Giardia: the role of the Lands cycle, 2001, pp.17, 316~319
- Long-Krug SA, "Phospholipase A enzymes of Entamoeba histolytica: description and subcellular localization", J Infect Dis, 152, pp.536~541 (1985)
- Sawyer MK, "Lipids from Entamoeba histolytica", Exp Parasitol, 20, pp.295~302 (1967)
- Moody S, "Virulent and a virulent Entamoeba histolytica and E. dispar differ in their cell surface phosphorylated Glycolipids", Parasitology, 114(Pt 2), pp.95~104 (1997)
- Shrimal S, "Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica", Sci Rep, 2, pp.333~ (2012)
- Petri Wa Jr, "Amebiasis and the Entamoeba histolytica Gal", GalNAc lectin: from lab bench to bedside, 1996, pp.44, 24~36
- Moody S, "Identification of significant variation in the composition of lipophosphoglycan-like molecules of E. histolytica and E. dispar", J Eukaryot Microbiol, 45, pp.9S~12S (1998)
- Srivastava G, "Lipophosphoglycan is present in distinctly different form in different Entamoeba histolytica strains and absent in Entamoeba moshkovskii and Entamoeba invadens", J Eukaryot Microbiol, 42, pp.617~622 (1995)
- Bhattacharya A, "The genome of Entamoeba histolytica", Int J Parasitol, 30, pp.401~410 (2000)
- Marinets A, "Protection against invasive amebiasis by a single monoclonal antibody directed against a lipophosphoglycan antigen localized on the surface of Entamoeba histolytica", J Exp Med, 186, pp.1557~1565 (1997)
- Seifert K, "A new approach for chemotherapy against Entamoeba histolytica", Arch Med Res, 31(4 Suppl), pp.S6~S7 (2000)
